PRKAG2
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.{{cite journal | vauthors = Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE | title = Mammalian AMP-activated protein kinase subfamily | journal = The Journal of Biological Chemistry | volume = 271 | issue = 2 | pages = 611–614 | date = January 1996 | pmid = 8557660 | doi = 10.1074/jbc.271.2.611 | doi-access = free }}{{cite journal | vauthors = Gao G, Fernandez CS, Stapleton D, Auster AS, Widmer J, Dyck JR, Kemp BE, Witters LA | title = Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 15 | pages = 8675–8681 | date = April 1996 | pmid = 8621499 | doi = 10.1074/jbc.271.15.8675 | doi-access = free }}{{cite web | title = Entrez Gene: PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51422}}
Function
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four CBS domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff–Parkinson–White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Interactions
PRKAG2 has been shown to interact with PRKAB2{{cite journal | vauthors = Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D | title = Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding | journal = The Biochemical Journal | volume = 346 Pt 3 | issue = Pt 3 | pages = 659–669 | date = March 2000 | pmid = 10698692 | pmc = 1220898 | doi = 10.1042/0264-6021:3460659 }} and PRKAB1.
References
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Further reading
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- {{cite journal | vauthors = Gollob MH, Green MS, Tang AS, Roberts R | title = PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy | journal = Current Opinion in Cardiology | volume = 17 | issue = 3 | pages = 229–234 | date = May 2002 | pmid = 12015471 | doi = 10.1097/00001573-200205000-00004 | s2cid = 33599152 }}
- {{cite journal | vauthors = Gollob MH | title = Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome | journal = Biochemical Society Transactions | volume = 31 | issue = Pt 1 | pages = 228–231 | date = February 2003 | pmid = 12546691 | doi = 10.1042/BST0310228 }}
- {{cite journal | vauthors = Ofir M, Hochhauser E, Vidne BA, Freimark D, Arad M | title = [AMP-activated protein kinase: how a mistake in energy gauge causes glycogen storage] | journal = Harefuah | volume = 146 | issue = 10 | pages = 770–5, 813–4 | date = October 2007 | pmid = 17990392 }}
- {{cite journal | vauthors = Hofmann B, Nishanian P, Baldwin RL, Insixiengmay P, Nel A, Fahey JL | title = HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism | journal = Journal of Immunology | volume = 145 | issue = 11 | pages = 3699–3705 | date = December 1990 | pmid = 1978848 | doi = 10.4049/jimmunol.145.11.3699 | doi-access = free }}
- {{cite journal | vauthors = MacRae CA, Ghaisas N, Kass S, Donnelly S, Basson CT, Watkins HC, Anan R, Thierfelder LH, McGarry K, Rowland E | title = Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3 | journal = The Journal of Clinical Investigation | volume = 96 | issue = 3 | pages = 1216–1220 | date = September 1995 | pmid = 7657794 | pmc = 185741 | doi = 10.1172/JCI118154 }}
- {{cite journal | vauthors = Hofmann B, Nishanian P, Nguyen T, Insixiengmay P, Fahey JL | title = Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 14 | pages = 6676–6680 | date = July 1993 | pmid = 7688126 | pmc = 46995 | doi = 10.1073/pnas.90.14.6676 | doi-access = free | bibcode = 1993PNAS...90.6676H }}
- {{cite journal | vauthors = Hofmann B, Nishanian P, Fan J, Nguyen T, Fahey JL | title = HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro | journal = AIDS | volume = 8 | issue = 7 | pages = 1016–1017 | date = July 1994 | pmid = 7946090 | doi = 10.1097/00002030-199407000-00025 }}
- {{cite journal | vauthors = Swingler S, Gallay P, Camaur D, Song J, Abo A, Trono D | title = The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix | journal = Journal of Virology | volume = 71 | issue = 6 | pages = 4372–4377 | date = June 1997 | pmid = 9151826 | pmc = 191654 | doi = 10.1128/JVI.71.6.4372-4377.1997 }}
- {{cite journal | vauthors = Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE | title = AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location | journal = FEBS Letters | volume = 409 | issue = 3 | pages = 452–456 | date = June 1997 | pmid = 9224708 | doi = 10.1016/S0014-5793(97)00569-3 | bibcode = 1997FEBSL.409..452S | s2cid = 39329574 }}
- {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 36 | pages = 22385–22388 | date = September 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 | doi-access = free }}
- {{cite journal | vauthors = Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F | title = Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways | journal = AIDS Research and Human Retroviruses | volume = 14 | issue = 10 | pages = 825–833 | date = July 1998 | pmid = 9671211 | doi = 10.1089/aid.1998.14.825 }}
- {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3–4 | pages = 184–192 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 | s2cid = 19529677 }}
- {{cite journal | title = Toward a complete human genome sequence | journal = Genome Research | volume = 8 | issue = 11 | pages = 1097–1108 | date = November 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 | doi-access = free | vauthors = Sanger Centre T, Washington University Genome Sequencing Cente T }}
- {{cite journal | vauthors = Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D | title = Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding | journal = The Biochemical Journal | volume = 346 Pt 3 | issue = Pt 3 | pages = 659–669 | date = March 2000 | pmid = 10698692 | pmc = 1220898 | doi = 10.1042/0264-6021:3460659 }}
- {{cite journal | vauthors = Lang T, Yu L, Tu Q, Jiang J, Chen Z, Xin Y, Liu G, Zhao S | title = Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36 | journal = Genomics | volume = 70 | issue = 2 | pages = 258–263 | date = December 2000 | pmid = 11112354 | doi = 10.1006/geno.2000.6376 }}
- {{cite journal | vauthors = Blair E, Redwood C, Ashrafian H, Oliveira M, Broxholme J, Kerr B, Salmon A, Ostman-Smith I, Watkins H | title = Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis | journal = Human Molecular Genetics | volume = 10 | issue = 11 | pages = 1215–1220 | date = May 2001 | pmid = 11371514 | doi = 10.1093/hmg/10.11.1215 | doi-access = free }}
- {{cite journal | vauthors = Gollob MH, Green MS, Tang AS, Gollob T, Karibe A, Ali Hassan AS, Ahmad F, Lozado R, Shah G, Fananapazir L, Bachinski LL, Roberts R | title = Identification of a gene responsible for familial Wolff-Parkinson-White syndrome | journal = The New England Journal of Medicine | volume = 344 | issue = 24 | pages = 1823–1831 | date = June 2001 | pmid = 11407343 | doi = 10.1056/NEJM200106143442403 | doi-access = free }}
- {{cite journal | vauthors = Hamilton SR, Stapleton D, O'Donnell JB, Kung JT, Dalal SR, Kemp BE, Witters LA | title = An activating mutation in the gamma1 subunit of the AMP-activated protein kinase | journal = FEBS Letters | volume = 500 | issue = 3 | pages = 163–168 | date = July 2001 | pmid = 11445078 | doi = 10.1016/S0014-5793(01)02602-3 | s2cid = 85248755 | doi-access = free | bibcode = 2001FEBSL.500..163H }}
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External links
- [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=hyper-card GeneReviews/NCBI/NIH/UW entry on Familial Hypertrophic Cardiomyopathy Overview]
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