PRKG1

{{Short description|Protein-coding gene in the species Homo sapiens}}

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.{{cite journal | vauthors = Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T | title = Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat | journal = FEBS Letters | volume = 255 | issue = 2 | pages = 321–9 | date = Sep 1989 | pmid = 2792381 | doi = 10.1016/0014-5793(89)81114-7 | s2cid = 83233954 | doi-access = }}{{cite journal | vauthors = Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T | title = Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10 | journal = Cytogenetics and Cell Genetics | volume = 59 | issue = 4 | pages = 270–3 | date = April 1992 | pmid = 1544322 | doi = 10.1159/000133267 }}{{cite web | title = Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5592}}

Interactions

PRKG1 has been shown to interact with:

GTF2I,{{cite journal | vauthors = Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB | title = cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I | journal = The Journal of Biological Chemistry | volume = 277 | issue = 35 | pages = 32003–14 | date = Aug 2002 | pmid = 12082086 | doi = 10.1074/jbc.M112332200 | doi-access = free }}
ITPR1,{{cite journal | vauthors = Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P | title = Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta | journal = Nature | volume = 404 | issue = 6774 | pages = 197–201 | date = Mar 2000 | pmid = 10724174 | doi = 10.1038/35004606 | bibcode = 2000Natur.404..197S | s2cid = 205004996 }}
MRVI1,{{cite journal | vauthors = Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J | title = Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 24153–9 | date = Jun 2001 | pmid = 11309393 | doi = 10.1074/jbc.M101530200 | doi-access = free }}
RGS2,{{cite journal | vauthors = Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G | title = Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure | journal = Nature Medicine | volume = 9 | issue = 12 | pages = 1506–12 | date = Dec 2003 | pmid = 14608379 | doi = 10.1038/nm958 | s2cid = 20331752 }} and
TNNT1.{{cite journal | vauthors = Yuasa K, Michibata H, Omori K, Yanaka N | title = A novel interaction of cGMP-dependent protein kinase I with troponin T | journal = The Journal of Biological Chemistry | volume = 274 | issue = 52 | pages = 37429–34 | date = Dec 1999 | pmid = 10601315 | doi = 10.1074/jbc.274.52.37429| doi-access = free }}

References

{{cite journal | vauthors = Picciotto MR, Cohn JA, Bertuzzi G, Greengard P, Nairn AC | title = Phosphorylation of the cystic fibrosis transmembrane conductance regulator | journal = The Journal of Biological Chemistry | volume = 267 | issue = 18 | pages = 12742–52 | date = Jun 1992 | doi = 10.1016/S0021-9258(18)42339-3 | pmid = 1377674 | doi-access = free }}
{{cite journal | vauthors = Thomas MK, Francis SH, Corbin JD | title = Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP | journal = The Journal of Biological Chemistry | volume = 265 | issue = 25 | pages = 14971–8 | date = Sep 1990 | doi = 10.1016/S0021-9258(18)77211-6 | pmid = 2168396 | doi-access = free }}
{{cite journal | vauthors = Pöhler D, Butt E, Meissner J, Müller S, Lohse M, Walter U, Lohmann SM, Jarchau T | title = Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system | journal = FEBS Letters | volume = 374 | issue = 3 | pages = 419–25 | date = Nov 1995 | pmid = 7589584 | doi = 10.1016/0014-5793(95)01168-E | s2cid = 25634004 | doi-access = free }}
{{cite journal | vauthors = Komalavilas P, Lincoln TM | title = Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase | journal = The Journal of Biological Chemistry | volume = 269 | issue = 12 | pages = 8701–7 | date = Mar 1994 | doi = 10.1016/S0021-9258(17)37024-2 | pmid = 8132598 | doi-access = free }}
{{cite journal | vauthors = Butt E, Abel K, Krieger M, Palm D, Hoppe V, Hoppe J, Walter U | title = cAMP- and cGMP-dependent protein kinase phosphorylation sites of the focal adhesion vasodilator-stimulated phosphoprotein (VASP) in vitro and in intact human platelets | journal = The Journal of Biological Chemistry | volume = 269 | issue = 20 | pages = 14509–17 | date = May 1994 | doi = 10.1016/S0021-9258(17)36652-8 | pmid = 8182057 | doi-access = free }}
{{cite journal | vauthors = Suko J, Maurer-Fogy I, Plank B, Bertel O, Wyskovsky W, Hohenegger M, Hellmann G | title = Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | volume = 1175 | issue = 2 | pages = 193–206 | date = Jan 1993 | pmid = 8380342 | doi = 10.1016/0167-4889(93)90023-I }}
{{cite journal | vauthors = Tamura N, Itoh H, Ogawa Y, Nakagawa O, Harada M, Chun TH, Suga S, Yoshimasa T, Nakao K | title = cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase | journal = Hypertension | volume = 27 | issue = 3 Pt 2 | pages = 552–7 | date = Mar 1996 | pmid = 8613202 | doi = 10.1161/01.hyp.27.3.552 }}
{{cite journal | vauthors = Salih E, Zhou HY, Glimcher MJ | title = Phosphorylation of purified bovine bone sialoprotein and osteopontin by protein kinases | journal = The Journal of Biological Chemistry | volume = 271 | issue = 28 | pages = 16897–905 | date = Jul 1996 | pmid = 8663267 | doi = 10.1074/jbc.271.28.16897 | doi-access = free }}
{{cite journal | vauthors = Xing J, Ginty DD, Greenberg ME | title = Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase | journal = Science | volume = 273 | issue = 5277 | pages = 959–63 | date = Aug 1996 | pmid = 8688081 | doi = 10.1126/science.273.5277.959 | bibcode = 1996Sci...273..959X | s2cid = 22226803 }}
{{cite journal | vauthors = Orstavik S, Natarajan V, Taskén K, Jahnsen T, Sandberg M | title = Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1) | journal = Genomics | volume = 42 | issue = 2 | pages = 311–8 | date = Jun 1997 | pmid = 9192852 | doi = 10.1006/geno.1997.4743 }}
{{cite journal | vauthors = Deak M, Clifton AD, Lucocq LM, Alessi DR | title = Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB | journal = The EMBO Journal | volume = 17 | issue = 15 | pages = 4426–41 | date = Aug 1998 | pmid = 9687510 | pmc = 1170775 | doi = 10.1093/emboj/17.15.4426 }}
{{cite journal | vauthors = Du K, Montminy M | title = CREB is a regulatory target for the protein kinase Akt/PKB | journal = The Journal of Biological Chemistry | volume = 273 | issue = 49 | pages = 32377–9 | date = Dec 1998 | pmid = 9829964 | doi = 10.1074/jbc.273.49.32377 | doi-access = free }}
{{cite journal | vauthors = Endo S, Suzuki M, Sumi M, Nairn AC, Morita R, Yamakawa K, Greengard P, Ito M | title = Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 5 | pages = 2467–72 | date = Mar 1999 | pmid = 10051666 | pmc = 26808 | doi = 10.1073/pnas.96.5.2467 | bibcode = 1999PNAS...96.2467E | doi-access = free }}
{{cite journal | vauthors = Wang X, Bruderer S, Rafi Z, Xue J, Milburn PJ, Krämer A, Robinson PJ | title = Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly | journal = The EMBO Journal | volume = 18 | issue = 16 | pages = 4549–59 | date = Aug 1999 | pmid = 10449420 | pmc = 1171529 | doi = 10.1093/emboj/18.16.4549 }}
{{cite journal | vauthors = Surks HK, Mochizuki N, Kasai Y, Georgescu SP, Tang KM, Ito M, Lincoln TM, Mendelsohn ME | title = Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha | journal = Science | volume = 286 | issue = 5444 | pages = 1583–7 | date = Nov 1999 | pmid = 10567269 | doi = 10.1126/science.286.5444.1583 }}
{{cite journal | vauthors = Yuasa K, Michibata H, Omori K, Yanaka N | title = A novel interaction of cGMP-dependent protein kinase I with troponin T | journal = The Journal of Biological Chemistry | volume = 274 | issue = 52 | pages = 37429–34 | date = Dec 1999 | pmid = 10601315 | doi = 10.1074/jbc.274.52.37429 | doi-access = free }}
{{cite journal | vauthors = Yuasa K, Omori K, Yanaka N | title = Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha | journal = The Journal of Biological Chemistry | volume = 275 | issue = 7 | pages = 4897–905 | date = Feb 2000 | pmid = 10671526 | doi = 10.1074/jbc.275.7.4897 | doi-access = free}}
{{cite journal | vauthors = Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD | title = Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle | journal = The Journal of Biological Chemistry | volume = 275 | issue = 8 | pages = 5504–11 | date = Feb 2000 | pmid = 10681529 | doi = 10.1074/jbc.275.8.5504 | doi-access = free }}

Category:EC 2.7.11

PRKG1

Interactions

References

Further reading