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PRKRA

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.{{cite web | title = Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8575}}{{cite journal | vauthors = Ito T, Yang M, May WS | title = RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling | journal = J. Biol. Chem. | volume = 274 | issue = 22 | pages = 15427–32 |date=May 1999 | pmid = 10336432 | doi = 10.1074/jbc.274.22.15427| doi-access = free }} PACT heterodimerizes with and activates protein kinase R.{{cite journal | vauthors = Patel RC, Sen GC | title = PACT, a protein activator of the interferon-induced protein kinase, PKR | journal = EMBO J. | volume = 17 | issue = 15 | pages = 4379–90 |date=August 1998 | pmid = 9687506 | pmc = 1170771 | doi = 10.1093/emboj/17.15.4379 }}{{cite journal | vauthors = Huang X, Hutchins B, Patel RC | title = The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR) | journal = Biochem. J. | volume = 366 | issue = Pt 1 | pages = 175–86 |date=August 2002 | pmid = 11985496 | pmc = 1222748 | doi = 10.1042/BJ20020204 }}

PRKRA mutations have been linked to a rare form of dystonia parkinsonism.{{cite journal | vauthors = Camargos S, Scholz S, Simón-Sánchez J, Paisán-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, Singleton AB | title = DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA | journal = Lancet Neurology | volume = 7 | issue = 3 | pages = 207–215 |date=March 2008 | pmid = 18243799 | doi = 10.1016/S1474-4422(08)70022-X | s2cid = 206157913 }}

References

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Further reading

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  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal |vauthors=Peters GA, Hartmann R, Qin J, etal |title=Modular structure of PACT: distinct domains for binding and activating PKR |journal=Mol Cell Biol |volume=21 |issue= 6 |pages= 1908–20 |year= 2001 |pmid= 11238927 |doi=10.1128/MCB.21.6.1908-1920.2001 |pmc=86773}}
  • {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
  • {{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
  • {{cite journal | vauthors=Horng T, Barton GM, Medzhitov R |title=TIRAP: an adapter molecule in the Toll signaling pathway |journal=Nat. Immunol. |volume=2 |issue= 9 |pages= 835–41 |year= 2001 |pmid= 11526399 |doi= 10.1038/ni0901-835 |s2cid=7296195 }}
  • {{cite journal | vauthors=Huang X, Hutchins B, Patel RC |title=The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR) |journal=Biochem. J. |volume=366 |issue= Pt 1 |pages= 175–86 |year= 2002 |pmid= 11985496 |doi= 10.1042/BJ20020204 | pmc=1222748 }}
  • {{cite journal | vauthors=Peters GA, Khoo D, Mohr I, Sen GC |title=Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein |journal=J. Virol. |volume=76 |issue= 21 |pages= 11054–64 |year= 2002 |pmid= 12368348 |doi=10.1128/JVI.76.21.11054-11064.2002 | pmc=136652 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Yang M, Ito T, May WS |title=A novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expression |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38325–32 |year= 2003 |pmid= 12874289 |doi= 10.1074/jbc.M303420200 |doi-access= free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal | vauthors=Bennett RL, Blalock WL, May WS |title=Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42687–93 |year= 2004 |pmid= 15299031 |doi= 10.1074/jbc.M403321200 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }}
  • {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |hdl= 11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access= free }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal | vauthors=Peters GA, Li S, Sen GC |title=Phosphorylation of specific serine residues in the PKR-activation domain of PACT is essential for its ability to mediate apoptosis |journal=J Biol Chem |volume=281 |issue= 46 |pages= 35129–36 |year= 2006 |pmid= 16982605 |doi=10.1074/jbc.M607714200|doi-access=free }}
  • {{cite journal |vauthors=Rowe TM, Rizzi M, Hirose K, Peters GA, etal |title=A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing|journal=Proc Natl Acad Sci USA |volume=103 |issue= 15 |pages= 5823–8 |year= 2006 |pmid= 16571658 |doi=10.1073/pnas.0601287103 |pmc=1458657|bibcode=2006PNAS..103.5823R|doi-access=free}}
  • {{cite journal |vauthors=Li S, Peters GA, Ding K, etal |title=Molecular basis for PKR activation by PACT or dsRNA|journal=Proc Natl Acad Sci USA |volume=103 |issue= 26 |pages= 10005–10 |year= 2006 |pmid= 16785445 |doi=10.1073/pnas.0602317103 |pmc=1502496|bibcode=2006PNAS..10310005L|doi-access=free}}
  • {{cite journal |vauthors=Lee Y, Hur I, Park SY, etal |title=The role of PACT in the RNA silencing pathway |journal=EMBO J. |volume=25 |issue= 3 |pages= 522–32 |year= 2006 |pmid= 16424907 |doi= 10.1038/sj.emboj.7600942 | pmc=1383527 }}
  • {{cite journal |vauthors=Bennett RL, Blalock WL, Abtahi DM, etal |title=RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection |journal=Blood |volume=108 |issue= 3 |pages= 821–9 |year= 2006 |pmid= 16861340 |doi= 10.1182/blood-2005-11-006817 | pmc=1617065 }}
  • {{cite journal |vauthors=Peters GA, Seachrist DD, Keri RA, etal |title=The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation |journal=Proc Natl Acad Sci USA |volume=106 |issue= 26 |pages= 10696–701 |year= 2009 |pmid= 19541653 |doi=10.1073/pnas.0900735106 |pmc=2705576|bibcode=2009PNAS..10610696P |doi-access=free }}

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