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PRKRIR

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

52 kDa repressor of the inhibitor of the protein kinase is an enzyme that in humans is encoded by the PRKRIR gene.{{cite journal |author1=Gale M Jr |author2=Blakely CM |author3=Hopkins DA |author4=Melville MW |author5=Wambach M |author6=Romano PR |author7=Katze MG | title = Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK | journal = Mol Cell Biol | volume = 18 | issue = 2 | pages = 859–71 |date=Feb 1998 | pmid = 9447982 | pmc = 108797 | doi = 10.1128/mcb.18.2.859}}{{cite web | title = Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5612}}

Interactions

PRKRIR has been shown to interact with STK4{{cite journal |last=Lin |first=Yenshou |author2=Khokhlatchev Andrei |author3=Figeys Daniel |author4=Avruch Joseph |date=Dec 2002 |title=Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis |journal=J. Biol. Chem. |volume=277 |issue=50 |pages=47991–8001 |location = United States| issn = 0021-9258| pmid = 12384512 |doi = 10.1074/jbc.M202630200 |doi-access=free }} and DNAJC3.

References

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Further reading

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  • {{cite journal |vauthors=Mellor H, Proud CG |title=A synthetic peptide substrate for initiation factor-2 kinases. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 2 |pages= 430–7 |year= 1991 |pmid= 1677563 |doi=10.1016/0006-291X(91)90125-Q }}
  • {{cite journal |vauthors=Polyak SJ, Tang N, Wambach M, etal |title=The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1702–7 |year= 1996 |pmid= 8576172 |doi=10.1074/jbc.271.3.1702 |doi-access=free }}
  • {{cite journal |vauthors=Shi Y, Vattem KM, Sood R, etal |title=Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7499–509 |year= 1998 |pmid= 9819435 |doi= 10.1128/MCB.18.12.7499| pmc=109330 }}
  • {{cite journal |vauthors=Lu J, O'Hara EB, Trieselmann BA, etal |title=The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32198–203 |year= 1999 |pmid= 10542257 |doi=10.1074/jbc.274.45.32198 |doi-access=free }}
  • {{cite journal |vauthors=Saelens X, Kalai M, Vandenabeele P |title=Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41620–8 |year= 2001 |pmid= 11555640 |doi= 10.1074/jbc.M103674200 |doi-access= free }}
  • {{cite journal |vauthors=Lin Y, Khokhlatchev A, Figeys D, Avruch J |title=Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 47991–8001 |year= 2003 |pmid= 12384512 |doi= 10.1074/jbc.M202630200 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Lee JH, Choi SR, Hwang TH, etal |title=A gene expression in study human gastric adenocarcinoma using a cDNA microarray. |journal=The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi |volume=42 |issue= 6 |pages= 484–95 |year= 2004 |pmid= 14695705 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}

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