PRKX

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y.

Mouse ortholog for this gene, Prkx, is also known as Pkare.{{cite web|url=https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=19108|title=Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]|publisher=National Center for Biotechnology Information}}

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• {{cite journal |vauthors=Li X, Li HP, Amsler K, Hyink D, Wilson PD, Burrow CR |title=PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue=14 |pages=9260–5 |year=2002 |pmid=12082174 |pmc=123128 |doi=10.1073/pnas.132051799 |bibcode=2002PNAS...99.9260L |doi-access=free }}
• {{cite journal |vauthors=Li X, Burrow CR, Polgar K, Hyink DP, Gusella GL, Wilson PD |title=Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency |journal=Biochim. Biophys. Acta |volume=1782 |issue=1 |pages=1–9 |year=2008 |pmid=17980165 |doi=10.1016/j.bbadis.2007.09.003 |s2cid=23224610 |url=https://hal.archives-ouvertes.fr/hal-00562802/file/PEER_stage2_10.1016%252Fj.bbadis.2007.09.003.pdf}}
• {{cite journal |vauthors=Li X, Iomini C, Hyink D, Wilson PD |title=PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation |journal=Dev. Biol. |volume=356 |issue=2 |pages=475–85 |year=2011 |pmid=21684272 |doi=10.1016/j.ydbio.2011.05.673 |doi-access=free }}
• {{cite journal |vauthors=Lin Y, Li W |title=MBD 4--a potential substrate for protein kinase X |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=43 |issue=11 |pages=916–7 |year=2011 |pmid=21971312 |doi=10.1093/abbs/gmr086 |doi-access=free }}
• {{cite journal |vauthors=Bender C, Ullrich A |title=PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines |journal=Int. J. Cancer |volume=131 |issue=2 |pages=E45–55 |year=2012 |pmid=22020623 |doi=10.1002/ijc.26486 |s2cid=27590197 }}
• {{cite journal |vauthors=Huang S, Li Q, Alberts I, Li X |title=PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development |journal=J. Cell. Biochem. |volume=117 |issue=3 |pages=566–73 |year=2016 |pmid=26252946 |doi=10.1002/jcb.25304 |s2cid=45734891 |doi-access=free }}

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