PRKY
{{Short description|Pseudogene in the species Homo sapiens}}
{{Infobox_gene}}
Serine/threonine-protein kinase PRKY is an enzyme that in humans is encoded by the PRKY gene.{{cite journal | vauthors = Klink A, Schiebel K, Winkelmann M, Rao E, Horsthemke B, Ludecke HJ, Claussen U, Scherer G, Rappold G | title = The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability | journal = Hum Mol Genet | volume = 4 | issue = 5 | pages = 869–78 |date=Sep 1995 | pmid = 7633447 | doi =10.1093/hmg/4.5.869 }}{{cite web | title = Entrez Gene: PRKY protein kinase, Y-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5616}}
This gene encodes a member of the cAMP-dependent serine/threonine protein kinase family. This gene is located on chromosome Y, near the boundary of the pseudoautosomal region. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females.
References
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Further reading
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- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, etal |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes |journal=Nature |volume=423 |issue= 6942 |pages= 825–37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 |bibcode=2003Natur.423..825S |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Jobling MA, Williams GA, Schiebel GA, etal |title=A selective difference between human Y-chromosomal DNA haplotypes |journal=Curr. Biol. |volume=8 |issue= 25 |pages= 1391–4 |year= 1999 |pmid= 9889101 |doi=10.1016/S0960-9822(98)00020-7 |doi-access=free |url=https://ora.ox.ac.uk/objects/uuid:3281c399-69b1-429b-aea4-c2218c43a0f2/files/mcfb4a8bf5b7ec074cba00938122edf73 }}
- {{cite journal |vauthors=Schiebel K, Winkelmann M, Mertz A, etal |title=Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females |journal=Hum. Mol. Genet. |volume=6 |issue= 11 |pages= 1985–9 |year= 1998 |pmid= 9302280 |doi=10.1093/hmg/6.11.1985 |doi-access=free }}
- {{cite journal |vauthors=Schiebel K, Mertz A, Winkelmann M, etal |title=FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12→q13 |journal=Cytogenet. Cell Genet. |volume=76 |issue= 1–2 |pages= 49–52 |year= 1997 |pmid= 9154127 |doi=10.1159/000134514 }}
- {{cite journal |vauthors=Gläser B, Hierl T, Taylor K, etal |title=High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin |journal=Chromosome Res. |volume=5 |issue= 1 |pages= 23–30 |year= 1997 |pmid= 9088640 |doi=10.1023/A:1018437301461 |s2cid=31543330 }}
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{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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