PRL

• Polish People's Republic (Polska Rzeczpospolita Ludowa), 1952–1989
• Punggol Regional Library, a regional library in Punggol, Singapore

• Pakistan Refinery Limited, a refinery in Karachi
• Penn Eastern Rail Lines, reporting mark

• Preferred Roaming List, in CDMA phones
• Proportional reduction in loss, a measure of reliability
• Protocol-relative link, URLs which do not specify a protocol

• Liberal Reformist Party (Dominican Republic)
• Parti Réformateur Libéral, a former political party in Belgium
• Party of the Radical Left (Partija radikalne levice), a political party in Serbia
• Republican Party of Liberty, a conservative political party in France, 1945–1951

• Premiership Rugby Limited, the organising body of Premiership Rugby

• Physical Research Laboratory, India
• Physical Review Letters, a scientific journal
• PRL-8-53, Nootropic research chemical
• Prolactin, a hormone

• Parramatta Rail Link, a formerly proposed railway project in Sydney, Australia

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