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PRMT6

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.{{cite journal | vauthors = Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT | title = The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity | journal = J Biol Chem | volume = 277 | issue = 5 | pages = 3537–43 |date=Jan 2002 | pmid = 11724789 | doi = 10.1074/jbc.M108786200 | doi-access = free }}{{cite web | title = Entrez Gene: PRMT6 protein arginine methyltransferase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55170}}

Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM]

References

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Further reading

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  • {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Boulanger MC, Liang C, Russell RS, etal |title=Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression |journal=J. Virol. |volume=79 |issue= 1 |pages= 124–31 |year= 2005 |pmid= 15596808 |doi= 10.1128/JVI.79.1.124-131.2005 | pmc=538702 }}
  • {{cite journal |vauthors=Sgarra R, Lee J, Tessari MA, etal |title=The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6 |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 3764–72 |year= 2006 |pmid= 16293633 |doi= 10.1074/jbc.M510231200 |doi-access= free |hdl= 11577/1565364 |hdl-access= free }}
  • {{cite journal |vauthors=Willemsen NM, Hitchen EM, Bodetti TJ, etal |title=Protein methylation is required to maintain optimal HIV-1 infectivity |journal=Retrovirology |volume=3 |pages= 92 |year= 2007 |pmid= 17169163 |doi= 10.1186/1742-4690-3-92 | pmc=1766367 |doi-access=free }}
  • {{cite journal | vauthors=Invernizzi CF, Xie B, Richard S, Wainberg MA |title=PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA |journal=Retrovirology |volume=3 |pages= 93 |year= 2007 |pmid= 17176473 |doi= 10.1186/1742-4690-3-93 | pmc=1779295 |doi-access=free }}
  • {{cite journal | vauthors=Xie B, Invernizzi CF, Richard S, Wainberg MA |title=Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region |journal=J. Virol. |volume=81 |issue= 8 |pages= 4226–34 |year= 2007 |pmid= 17267505 |doi= 10.1128/JVI.01888-06 | pmc=1866113 }}
  • {{cite journal |vauthors=Guccione E, Bassi C, Casadio F, etal |title=Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive |journal=Nature |volume=449 |issue= 7164 |pages= 933–7 |year= 2007 |pmid= 17898714 |doi= 10.1038/nature06166 |bibcode=2007Natur.449..933G |s2cid=4341782 }}

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