PRMT8
{{Short description|Protein-coding gene in the species Homo sapiens}}
Protein arginine methyltransferase 8 is a protein that in humans is encoded by the PRMT8 gene.{{cite web | title = Protein arginine methyltransferase 8| url = https://www.ncbi.nlm.nih.gov/gene/56341| access-date = 2011-12-04}} Arginine methylation is a posttranslational modification involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction and protein compartmentalization. PRMT8 binds and dimethylates Ewing sarcoma breakpoint region 1 (EWS) protein.{{Cite journal
| last1 = Kim | first1 = J. D.
| last2 = Kako | first2 = K.
| last3 = Kakiuchi | first3 = M.
| last4 = Park | first4 = G. G.
| last5 = Fukamizu | first5 = A.
| title = EWS is a substrate of type I protein arginine methyltransferase, PRMT8
| journal = International Journal of Molecular Medicine
| volume = 22
| issue = 3
| pages = 309–315
| year = 2008
| pmid = 18698489
}}
References
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Further reading
{{refbegin | 2}}
- {{Cite journal
| last1 = Pahlich | first1 = S.
| last2 = Zakaryan | first2 = R. P.
| last3 = Gehring | first3 = H.
| doi = 10.1002/prot.22004
| title = Identification of proteins interacting with protein arginine methyltransferase 8: The Ewing sarcoma (EWS) protein binds independent of its methylation state
| journal = Proteins: Structure, Function, and Bioinformatics
| volume = 72
| issue = 4
| pages = 1125–1137
| year = 2008
| pmid = 18320585
| pmc =
| s2cid = 206402713
}}
- {{Cite journal
| last1 = Sayegh | first1 = J.
| last2 = Webb | first2 = K.
| last3 = Cheng | first3 = D.
| last4 = Bedford | first4 = M. T.
| last5 = Clarke | first5 = S. G.
| title = Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain
| doi = 10.1074/jbc.M704650200
| journal = Journal of Biological Chemistry
| volume = 282
| issue = 50
| pages = 36444–36453
| year = 2007
| pmid = 17925405
| pmc =
| doi-access = free
}}
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Category:Genes mutated in mice
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