PROX1

PROX1 has been shown to interact with EP300.{{cite journal |last=Chen |first=Qin |author2=Dowhan Dennis H |author3=Liang Dongcai |author4=Moore David D |author5=Overbeek Paul A |date=Jul 2002 |title=CREB-binding protein/p300 co-activation of crystallin gene expression |journal=J. Biol. Chem. |volume=277 |issue=27 |pages=24081–9 |location = United States| issn = 0021-9258| pmid = 11943779 |doi = 10.1074/jbc.M201821200 |doi-access=free }}

PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found [http://www.brain-map.org/search/index.html?query=prox1 here].

PROX1 is used as a marker for lymphatic endothelium in biopsy samples.

PROX2

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• {{cite journal | author=Hong YK |title=Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate |journal=Dev. Dyn. |volume=225 |issue= 3 |pages= 351–7 |year= 2003 |pmid= 12412020 |doi= 10.1002/dvdy.10163 |name-list-style=vanc| author2=Harvey N | author3=Noh YH | display-authors=3 | last4=Schacht | first4=Vivien | last5=Hirakawa | first5=Satoshi | last6=Detmar | first6=Michael | last7=Oliver | first7=Guillermo | doi-access=free }}
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• {{cite journal | author=Nagai H |title=Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies |journal=Genes Chromosomes Cancer |volume=38 |issue= 1 |pages= 13–21 |year= 2003 |pmid= 12874782 |doi= 10.1002/gcc.10248 |name-list-style=vanc| author2=Li Y | author3=Hatano S | display-authors=3 | last4=Toshihito | first4=Ohno | last5=Yuge | first5=Masayuki | last6=Ito | first6=Etsuro | last7=Utsumi | first7=Makoto | last8=Saito | first8=Hidehiko | last9=Kinoshita | first9=Tomohiro |s2cid=35135526 }}
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• {{cite journal | author=Dudas J |title=The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium |journal=Anat. Embryol. |volume=208 |issue= 5 |pages= 359–66 |year= 2005 |pmid= 15232737 |doi= 10.1007/s00429-004-0403-4 |name-list-style=vanc| author2=Papoutsi M | author3=Hecht M | display-authors=3 | last4=Elmaouhoub | first4=A. | last5=Saile | first5=B. | last6=Christ | first6=B. | last7=Tomarev | first7=S.I. | last8=Kaisenberg | first8=C.S. | last9=Schweigerer | first9=L. |s2cid=117581 }}
• {{cite journal | author=Reis RM |title=Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors |journal=Pathol. Res. Pract. |volume=201 |issue= 12 |pages= 771–6 |year= 2006 |pmid= 16308102 |doi= 10.1016/j.prp.2005.08.010 |name-list-style=vanc| author2=Reis-Filho JS | author3=Longatto Filho A | display-authors=3 | last4=Tomarev | first4=S | last5=Silva | first5=P | last6=Lopes | first6=J |hdl=1822/5789 |hdl-access=free}}
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• {{cite journal | author=Laerm A |title=Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system |journal=J. Hepatol. |volume=46 |issue= 1 |pages= 89–97 |year= 2007 |pmid= 17069925 |doi= 10.1016/j.jhep.2006.07.033 |name-list-style=vanc| author2=Helmbold P | author3=Goldberg M | display-authors=3 | last4=Dammann | first4=R | last5=Holzhausen | first5=H | last6=Ballhausen | first6=W }}

{{refend}}

• {{MeshName|PROX1+protein,+human}}
• {{PDBe-KB2|Q92786|Prospero homeobox protein 1}}

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{{Transcription factors}}

Category:Transcription factors