PRPF19

{{Short description|Protein-coding gene in the species Homo sapiens}}

Pre-mRNA-processing factor 19 is a protein that in humans is encoded by the PRPF19 gene.{{cite journal | author = Mahajan KN, Mitchell BS | title = Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 19 | pages = 10746–51 |date=September 2003 | pmid = 12960389 | pmc = 196874 | doi = 10.1073/pnas.1631060100 | bibcode = 2003PNAS..10010746M | doi-access = free }}{{cite web | title = Entrez Gene: PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27339| accessdate = }}

In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM]

Interactions

PRPF19 has been shown to interact with CDC5L.{{cite journal |last=Ajuh |first=P |author2=Kuster B |author3=Panov K |author4=Zomerdijk J C |author5=Mann M |author6=Lamond A I |date=December 2000 |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry |journal=EMBO J. |volume=19 |issue=23 |pages=6569–81 | issn = 0261-4189| pmid = 11101529 |doi = 10.1093/emboj/19.23.6569 |pmc=305846 }}

References

{{cite journal |vauthors=Gerner C, Holzmann K, Meissner M, etal |title=Reassembling proteins and chaperones in human nuclear matrix protein fractions. |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 145–51 |year= 1999 |pmid= 10404385 |doi=10.1002/(SICI)1097-4644(19990801)74:2<145::AID-JCB1>3.0.CO;2-# |s2cid=196598497 }}
{{cite journal |vauthors=Gotzmann J, Gerner C, Meissner M, etal |title=hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. |journal=Exp. Cell Res. |volume=261 |issue= 1 |pages= 166–79 |year= 2000 |pmid= 11082287 |doi= 10.1006/excr.2000.5025 }}
{{cite journal |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |s2cid=14132033 |doi-access=free |bibcode=2002CBio...12....1A }}
{{cite journal |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266 }}
{{cite journal |vauthors=Scherl A, Couté Y, Déon C, etal |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Makarova OV, Makarov EM, Urlaub H, etal |title=A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. |journal=EMBO J. |volume=23 |issue= 12 |pages= 2381–91 |year= 2004 |pmid= 15175653 |doi= 10.1038/sj.emboj.7600241 | pmc=423283 }}
{{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free |bibcode=2004CBio...14.1436J }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 }}
{{cite journal |vauthors=Löscher M, Fortschegger K, Ritter G, etal |title=Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 593–603 |year= 2005 |pmid= 15660529 |doi= 10.1042/BJ20041517 | pmc=1138967 }}
{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
{{cite journal |vauthors=Zhang N, Kaur R, Lu X, etal |title=The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. |journal=J. Biol. Chem. |volume=280 |issue= 49 |pages= 40559–67 |year= 2006 |pmid= 16223718 |doi= 10.1074/jbc.M508453200 |doi-access= free }}
{{cite journal |vauthors=Grillari J, Ajuh P, Stadler G, etal |title=SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. |journal=Nucleic Acids Res. |volume=33 |issue= 21 |pages= 6868–83 |year= 2005 |pmid= 16332694 |doi= 10.1093/nar/gki986 | pmc=1310963 }}
{{cite journal |vauthors=Voglauer R, Chang MW, Dampier B, etal |title=SNEV overexpression extends the life span of human endothelial cells. |journal=Exp. Cell Res. |volume=312 |issue= 6 |pages= 746–59 |year= 2006 |pmid= 16388800 |doi= 10.1016/j.yexcr.2005.11.025 }}
{{cite journal | author=Lu X, Legerski RJ |title=The Prp19/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage. |journal=Biochem. Biophys. Res. Commun. |volume=354 |issue= 4 |pages= 968–74 |year= 2007 |pmid= 17276391 |doi= 10.1016/j.bbrc.2007.01.097 | pmc=1810354 }}
{{cite journal |vauthors=Fortschegger K, Wagner B, Voglauer R, etal |title=Early embryonic lethality of mice lacking the essential protein SNEV. |journal=Mol. Cell. Biol. |volume=27 |issue= 8 |pages= 3123–30 |year= 2007 |pmid= 17283042 |doi= 10.1128/MCB.01188-06 | pmc=1899945 }}
{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}

PRPF19

Interactions

References

Further reading