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PRPF40A

{{Short description|Protein-coding gene in the species Homo sapiens}}

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{{Use dmy dates|date=April 2023}}

{{Infobox_gene}}

Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.{{cite journal |vauthors=Bedford MT, Reed R, Leder P | title = WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 18 | pages = 10602–7 |date=Sep 1998 | pmid = 9724750 | pmc = 27941 | doi =10.1073/pnas.95.18.10602 | bibcode =1998PNAS...9510602B | doi-access = free }}{{cite journal |vauthors=Wiesner S, Stier G, Sattler M, Macias MJ | title = Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40 | journal = J Mol Biol | volume = 324 | issue = 4 | pages = 807–22 |date=Dec 2002 | pmid = 12460579 | doi =10.1016/S0022-2836(02)01145-2 }}{{cite web | title = Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55660}}

Interactions

PRPF40A has been shown to interact with Huntingtin.{{cite journal |last=Faber |first=P W |author2=Barnes G T |author3=Srinidhi J |author4=Chen J |author5=Gusella J F |author6=MacDonald M E |date=Sep 1998 |title=Huntingtin interacts with a family of WW domain proteins |journal=Hum. Mol. Genet. |volume=7 |issue=9 |pages=1463–74 | issn = 0964-6906| pmid = 9700202 |doi=10.1093/hmg/7.9.1463 |doi-access=free }}

References

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Further reading

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  • {{cite journal |vauthors=Chan DC, Bedford MT, Leder P |title=Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1045–54 |year= 1996 |pmid= 8605874 |doi= 10.1002/j.1460-2075.1996.tb00442.x| pmc=450002 }}
  • {{cite journal |vauthors=Bedford MT, Chan DC, Leder P |title=FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2376–83 |year= 1997 |pmid= 9171351 |doi= 10.1093/emboj/16.9.2376 | pmc=1169838 }}
  • {{cite journal |vauthors=Faber PW, Barnes GT, Srinidhi J, etal |title=Huntingtin interacts with a family of WW domain proteins. |journal=Hum. Mol. Genet. |volume=7 |issue= 9 |pages= 1463–74 |year= 1998 |pmid= 9700202 |doi=10.1093/hmg/7.9.1463 |doi-access=free }}
  • {{cite journal |vauthors=Scanlan MJ, Gordan JD, Williamson B, etal |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 |s2cid=21839750 |doi-access= }}
  • {{cite journal |vauthors=Bedford MT, Sarbassova D, Xu J, etal |title=A novel pro-Arg motif recognized by WW domains. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10359–69 |year= 2000 |pmid= 10744724 |doi=10.1074/jbc.275.14.10359 |doi-access=free }}
  • {{cite journal |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 }}
  • {{cite journal |vauthors=Wenzel J, Sanzenbacher R, Ghadimi M, etal |title=Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. |journal=FEBS Lett. |volume=509 |issue= 2 |pages= 255–62 |year= 2002 |pmid= 11741599 |doi=10.1016/S0014-5793(01)03174-X |s2cid=33084576 |doi-access= }}
  • {{cite journal |vauthors=Allen M, Friedler A, Schon O, Bycroft M |title=The structure of an FF domain from human HYPA/FBP11. |journal=J. Mol. Biol. |volume=323 |issue= 3 |pages= 411–6 |year= 2002 |pmid= 12381297 |doi=10.1016/S0022-2836(02)00968-3 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Katoh M, Katoh M |title=Identification and characterization of human FNBP3 gene in silico. |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 651–6 |year= 2004 |pmid= 12964049 |doi= 10.3892/ijmm.12.4.651}}
  • {{cite journal |vauthors=Busino L, Donzelli M, Chiesa M, etal |title=Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. |journal=Nature |volume=426 |issue= 6962 |pages= 87–91 |year= 2003 |pmid= 14603323 |doi= 10.1038/nature02082 |bibcode=2003Natur.426...87B |s2cid=768783 }}
  • {{cite journal |vauthors=Mizutani K, Suetsugu S, Takenawa T |title=FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 468–74 |year= 2004 |pmid= 14697212 |doi=10.1016/j.bbrc.2003.11.139 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
  • {{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free |bibcode=2004CBio...14.1436J }}
  • {{cite journal |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 |doi-access= free }}
  • {{cite journal |vauthors=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 | pmc=517884 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

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{{PDB Gallery|geneid=55660}}

{{Post transcriptional modification}}

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