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PRPF4B

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.{{cite journal |vauthors=Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 1 | pages = 31–9 |date=Aug 1998 | pmid = 9628581 | doi =10.1093/dnares/5.1.31 | doi-access = free }}{{cite journal |vauthors=Kojima T, Zama T, Wada K, Onogi H, Hagiwara M | title = Cloning of human PRP4 reveals interaction with Clk1 | journal = J Biol Chem | volume = 276 | issue = 34 | pages = 32247–56 |date=Aug 2001 | pmid = 11418604 | doi = 10.1074/jbc.M103790200 | doi-access = free }}{{cite web | title = Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8899}}

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).

Interactions

PRPF4B has been shown to interact with Pinin.{{cite journal |last=Dellaire |first=Graham |author2=Makarov Evgeny M |author3=Cowger Jeff J M |author4=Longman Dasa |author5=Sutherland Heidi G E |author6=Lührmann Reinhard |author7=Torchia Joseph |author8=Bickmore Wendy A |date=Jul 2002 |title=Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes |journal=Mol. Cell. Biol. |volume=22 |issue=14 |pages=5141–56 |location = United States| issn = 0270-7306| pmid = 12077342 |doi=10.1128/MCB.22.14.5141-5156.2002 |pmc=139773 |hdl=11858/00-001M-0000-0029-BC76-A}}

References

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Further reading

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  • {{cite journal |vauthors=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 }}
  • {{cite journal |vauthors=Gross T, Lützelberger M, Weigmann H, etal |title=Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue |journal=Nucleic Acids Res. |volume=25 |issue= 5 |pages= 1028–35 |year= 1997 |pmid= 9102632 |doi=10.1093/nar/25.5.1028 | pmc=146536 }}
  • {{cite journal |vauthors=Huang Y, Deng T, Winston BW |title=Characterization of hPRP4 kinase activation: potential role in signaling |journal=Biochem. Biophys. Res. Commun. |volume=271 |issue= 2 |pages= 456–63 |year= 2000 |pmid= 10799319 |doi= 10.1006/bbrc.2000.2651 }}
  • {{cite journal |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266 }}
  • {{cite journal |vauthors=Dellaire G, Makarov EM, Cowger JJ, etal |title=Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes |journal=Mol. Cell. Biol. |volume=22 |issue= 14 |pages= 5141–56 |year= 2002 |pmid= 12077342 |doi=10.1128/MCB.22.14.5141-5156.2002 | pmc=139773 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 }}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
  • {{cite journal |vauthors=Bennett EM, Lever AM, Allen JF |title=Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2 |journal=J. Virol. |volume=78 |issue= 20 |pages= 11303–12 |year= 2004 |pmid= 15452250 |doi= 10.1128/JVI.78.20.11303-11312.2004 | pmc=521795 }}
  • {{cite journal |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |s2cid=7200157 }}
  • {{cite journal |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL, etal |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 |doi-access= free }}
  • {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |hdl= 11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access= free }}
  • {{cite journal |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |doi-access=free }}
  • {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
  • {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
  • {{cite journal |vauthors=Huang B, Ahn YT, McPherson L, etal |title=Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7081–7 |year= 2007 |pmid= 17513757 |doi= 10.4049/jimmunol.178.11.7081| pmc=2674583 }}

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{{Post transcriptional modification}}

{{protein-stub}}