PRPSAP2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene.{{cite web | title = Entrez Gene: phosphoribosyl pyrophosphate synthetase-associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=5636| access-date = 2011-08-30}}
Function
The enzyme phosphoribosyl pyrophosphate synthetase (PRS) catalyzes the formation of phosphoribosyl pyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Katashima R, Iwahana H, Fujimura M, etal |title=Molecular cloning of a human cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein. |journal=Biochim. Biophys. Acta |volume=1396 |issue= 3 |pages= 245–50 |year= 1998 |pmid= 9545573 |doi= 10.1016/S0167-4781(97)00217-0}}
- {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |hdl= 11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access= free }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
- {{cite journal |vauthors=Katashima R, Iwahana H, Fujimura M, etal |title=Assignment of the human phosphoribosylpyrophosphate synthetase-associated protein 41 gene (PRPSAP2) to 17p11.2-p12. |journal=Genomics |volume=54 |issue= 1 |pages= 180–1 |year= 1998 |pmid= 9806849 |doi= 10.1006/geno.1998.5432 }}
- {{cite journal |vauthors=Low SK, Kuchiba A, Zembutsu H, etal |title=Genome-wide association study of pancreatic cancer in Japanese population. |journal=PLOS ONE |volume=5 |issue= 7 |pages= e11824 |year= 2010 |pmid= 20686608 |doi= 10.1371/journal.pone.0011824 |pmc=2912284|bibcode=2010PLoSO...511824L |doi-access=free }}
{{refend}}
Category:Genes mutated in mice
{{gene-17-stub}}