PRSS22
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene.{{cite web | title = Entrez Gene: protease| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64063}}{{cite journal |vauthors=Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL | title = Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells | journal = J. Biol. Chem. | volume = 276 | issue = 52 | pages = 49169–82 |date=December 2001 | pmid = 11602603 | doi = 10.1074/jbc.M108677200 | doi-access = free }}{{cite journal |vauthors=Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL | title = Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22 | journal = Blood | volume = 105 | issue = 10 | pages = 3893–901 |date=May 2005 | pmid = 15701722 | pmc = 1895090 | doi = 10.1182/blood-2003-10-3501 }}
This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16.
See also
References
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Further reading
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- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 |pmc=403697}}
- {{cite journal |vauthors=Martin J, Han C, Gordon LA, etal |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2004 |pmid= 15616553 |doi= 10.1038/nature03187 |bibcode=2004Natur.432..988M |doi-access= free }}
- {{cite journal |vauthors=Mitsui S, Okui A, Kominami K, etal |title=A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. |journal=FEBS J. |volume=272 |issue= 19 |pages= 4911–23 |year= 2005 |pmid= 16176265 |doi= 10.1111/j.1742-4658.2005.04901.x |s2cid=25290079 |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
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{{Serine endopeptidases}}
{{Enzymes}}
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