PSRC1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Proline/serine-rich coiled-coil protein 1 is a protein that in humans is encoded by the PSRC1 gene.{{cite journal | vauthors = Lo PK, Wang FF | title = Cloning and characterization of human and mouse DDA3 genes | journal = Biochim Biophys Acta | volume = 1579 | issue = 2–3 | pages = 214–8 |date=Nov 2002 | pmid = 12427559 | doi = 10.1016/s0167-4781(02)00512-2}}{{cite journal | vauthors = Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF | title = Identification of a novel mouse p53 target gene DDA3 | journal = Oncogene | volume = 18 | issue = 54 | pages = 7765–74 |date=Feb 2000 | pmid = 10618717 | doi = 10.1038/sj.onc.1203167 | doi-access = free }}{{cite web | title = Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84722}}
This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. Alternatively spliced transcript variants encoding different isoforms have been described.
References
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Further reading
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- {{cite journal |vauthors=Kathiresan S, Melander O, Guiducci C, etal |title=Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans |journal=Nat. Genet. |volume=40 |issue= 2 |pages= 189–97 |year= 2008 |pmid= 18193044 |doi= 10.1038/ng.75 | pmc=2682493 }}
- {{cite journal |vauthors=Wallace C, Newhouse SJ, Braund P, etal |title=Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia |journal=Am. J. Hum. Genet. |volume=82 |issue= 1 |pages= 139–49 |year= 2008 |pmid= 18179892 |doi= 10.1016/j.ajhg.2007.11.001 | pmc=2253977 }}
- {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }}
- {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
- {{cite journal |vauthors=Wan D, Gong Y, Qin W, etal |title=Large-scale cDNA transfection screening for genes related to cancer development and progression |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 | pmc=524842 |bibcode=2004PNAS..10115724W |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
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