PTP4A3

{{Short description|Protein-coding gene in the species Homo sapiens}}

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.{{cite web | title = Entrez Gene: PTP4A3 protein tyrosine phosphatase type IVA, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11156}}

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.

References

{{cite journal |vauthors=Zeng Q, Hong W, Tan YH |title=Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1 |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 2 |pages= 421–7 |year= 1998 |pmid= 9514946 |doi= 10.1006/bbrc.1998.8291 }}
{{cite journal |vauthors=Dayton MA, Knobloch TJ |title=Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38 |journal=Receptors & Signal Transduction |volume=7 |issue= 4 |pages= 241–56 |year= 1998 |pmid= 9633825 }}
{{cite journal | author=Zeng Q |title=Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21444–52 |year= 2000 |pmid= 10747914 |doi= 10.1074/jbc.M000453200 |name-list-style=vanc| author2=Si X | author3=Horstmann H | display-authors=3 | last4=Xu | first4=Y | last5=Hong | first5=W | last6=Pallen | first6=CJ | doi-access=free}}
{{cite journal | author=Matter WF |title=Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 5 |pages= 1061–8 |year= 2001 |pmid= 11355880 |doi= 10.1006/bbrc.2001.4881 |name-list-style=vanc| author2=Estridge T | author3=Zhang C | display-authors=3 | last4=Belagaje | first4=Rama | last5=Stancato | first5=Louis | last6=Dixon | first6=Jeff | last7=Johnson | first7=Brian | last8=Bloem | first8=Laura | last9=Pickard | first9=Todd }}
{{cite journal | author=Saha S |title=A phosphatase associated with metastasis of colorectal cancer |journal=Science |volume=294 |issue= 5545 |pages= 1343–6 |year= 2001 |pmid= 11598267 |doi= 10.1126/science.1065817 |author2-link=Alberto Bardelli |name-list-style=vanc| author2=Bardelli A | author3=Buckhaults P | display-authors=3 | last4=Velculescu | first4=VE | last5=Rago | first5=C | last6=St Croix | first6=B | last7=Romans | first7=KE | last8=Choti | first8=MA | last9=Lengauer | first9=C |bibcode=2001Sci...294.1343S |s2cid=42104960 }}
{{cite journal |vauthors=Wang J, Kirby CE, Herbst R |title=The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46659–68 |year= 2003 |pmid= 12235145 |doi= 10.1074/jbc.M206407200 |doi-access= free }}
{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal | author=Pathak MK |title=Pentamidine is an inhibitor of PRL phosphatases with anticancer activity |journal=Mol. Cancer Ther. |volume=1 |issue= 14 |pages= 1255–64 |year= 2003 |pmid= 12516958 |name-list-style=vanc| author2=Dhawan D | author3=Lindner DJ | display-authors=3 | last4=Borden | first4=EC | last5=Farver | first5=C | last6=Yi | first6=T }}
{{cite journal | author=Zeng Q |title=PRL-3 and PRL-1 promote cell migration, invasion, and metastasis |journal=Cancer Res. |volume=63 |issue= 11 |pages= 2716–22 |year= 2003 |pmid= 12782572 |name-list-style=vanc| author2=Dong JM | author3=Guo K | display-authors=3 | last4=Li | first4=J | last5=Tan | first5=HX | last6=Koh | first6=V | last7=Pallen | first7=CJ | last8=Manser | first8=E | last9=Hong | first9=W }}
{{cite journal | author=Bardelli A |title=PRL-3 expression in metastatic cancers |journal=Clin. Cancer Res. |volume=9 |issue= 15 |pages= 5607–15 |year= 2004 |pmid= 14654542 |name-list-style=vanc| author2=Saha S | author3=Sager JA | display-authors=3 | last4=Romans | first4=KE | last5=Xin | first5=B | last6=Markowitz | first6=SD | last7=Lengauer | first7=C | last8=Velculescu | first8=VE | last9=Kinzler | first9=KW }}
{{cite journal | author=Kozlov G |title=Structural insights into molecular function of the metastasis-associated phosphatase PRL-3 |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11882–9 |year= 2004 |pmid= 14704153 |doi= 10.1074/jbc.M312905200 |name-list-style=vanc| author2=Cheng J | author3=Ziomek E | display-authors=3 | last4=Banville | first4=D | last5=Gehring | first5=K | last6=Ekiel | first6=I | doi-access=free}}
{{cite journal | author=Kim KA |title=Structure of human PRL-3, the phosphatase associated with cancer metastasis |journal=FEBS Lett. |volume=565 |issue= 1–3 |pages= 181–7 |year= 2004 |pmid= 15135076 |doi= 10.1016/j.febslet.2004.03.062 |name-list-style=vanc| author2=Song JS | author3=Jee J | display-authors=3 | last4=Sheen | first4=Mee Rie | last5=Lee | first5=Chulhyun | last6=Lee | first6=Tae Gyu | last7=Ro | first7=Seonggu | last8=Cho | first8=Joong Myung | last9=Lee | first9=Weontae |s2cid=29552515 | doi-access=free }}
{{cite journal | author=Wu X |title=Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells |journal=Am. J. Pathol. |volume=164 |issue= 6 |pages= 2039–54 |year= 2004 |pmid= 15161639 |doi= 10.1016/S0002-9440(10)63763-7| pmc=1615773 |name-list-style=vanc| author2=Zeng H | author3=Zhang X | display-authors=3 | last4=Zhao | first4=Y | last5=Sha | first5=H | last6=Ge | first6=X | last7=Zhang | first7=M | last8=Gao | first8=X | last9=Xu | first9=Q }}
{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{cite journal | author=Kato H |title=High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases |journal=Clin. Cancer Res. |volume=10 |issue= 21 |pages= 7318–28 |year= 2005 |pmid= 15534108 |doi= 10.1158/1078-0432.CCR-04-0485 |name-list-style=vanc| author2=Semba S | author3=Miskad UA | display-authors=3 | last4=Seo | first4=Y | last5=Kasuga | first5=M | last6=Yokozaki | first6=H | doi-access=free}}
{{cite journal | author=Li J |title=Generation of PRL-3- and PRL-1-specific monoclonal antibodies as potential diagnostic markers for cancer metastases |journal=Clin. Cancer Res. |volume=11 |issue= 6 |pages= 2195–204 |year= 2005 |pmid= 15788667 |doi= 10.1158/1078-0432.CCR-04-1984 |name-list-style=vanc| author2=Guo K | author3=Koh VW | display-authors=3 | last4=Tang | first4=JP | last5=Gan | first5=BQ | last6=Shi | first6=H | last7=Li | first7=HX | last8=Zeng | first8=Q | doi-access=free }}
{{cite journal | author=Polato F |title=PRL-3 phosphatase is implicated in ovarian cancer growth |journal=Clin. Cancer Res. |volume=11 |issue= 19 Pt 1 |pages= 6835–9 |year= 2006 |pmid= 16203771 |doi= 10.1158/1078-0432.CCR-04-2357 |name-list-style=vanc| author2=Codegoni A | author3=Fruscio R | display-authors=3 | last4=Perego | first4=P | last5=Mangioni | first5=C | last6=Saha | first6=S | last7=Bardelli | first7=A | last8=Broggini | first8=M | doi-access=free }}
{{cite journal | author=Peng L |title=Identification of integrin alpha1 as an interacting protein of protein tyrosine phosphatase PRL-3 |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 1 |pages= 179–83 |year= 2006 |pmid= 16472776 |doi= 10.1016/j.bbrc.2006.01.102 |name-list-style=vanc| author2=Jin G | author3=Wang L | display-authors=3 | last4=Guo | first4=Jianpin | last5=Meng | first5=Lin | last6=Shou | first6=Chengchao }}
{{cite journal | author=Rouleau C |title=Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function |journal=Mol. Cancer Ther. |volume=5 |issue= 2 |pages= 219–29 |year= 2006 |pmid= 16505094 |doi= 10.1158/1535-7163.MCT-05-0289 |name-list-style=vanc| author2=Roy A | author3=St Martin T | display-authors=3 | last4=Dufault | first4=MR | last5=Boutin | first5=P | last6=Liu | first6=D | last7=Zhang | first7=M | last8=Puorro-Radzwill | first8=K | last9=Rulli | first9=L | doi-access=free }}
{{cite journal | author=Radke I |title=Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer |journal=Br. J. Cancer |volume=95 |issue= 3 |pages= 347–54 |year= 2006 |pmid= 16832410 |doi= 10.1038/sj.bjc.6603261 | pmc=2360632 |name-list-style=vanc| author2=Götte M | author3=Kersting C | display-authors=3 | last4=Mattsson | first4=B | last5=Kiesel | first5=L | last6=Wülfing | first6=P }}

PTP4A3

References

Further reading