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PTPN12

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Use mdy dates|date=May 2011}}

{{Infobox_gene}}

Tyrosine-protein phosphatase non-receptor type 12 is an enzyme that in humans is encoded by the PTPN12 gene.{{cite journal |vauthors=Takekawa M, Itoh F, Hinoda Y, Adachi M, Ariyama T, Inazawa J, Imai K, Yachi A | title = Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells | journal = FEBS Lett | volume = 339 | issue = 3 | pages = 222–8 |date=Mar 1994 | pmid = 7509295 | doi =10.1016/0014-5793(94)80420-6 | s2cid = 4885570 | doi-access = }}{{cite web | title = Entrez Gene: PTPN12 protein tyrosine phosphatase, non-receptor type 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5782}}

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein–protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.

Interactions

PTPN12 has been shown to interact with BCAR1,{{cite journal |last=Lin |first=Yi |author2=Ceacareanu Alice Corina |author3=Hassid Aviv |date=Aug 2003 |title=Nitric oxide-induced inhibition of aortic smooth muscle cell motility: role of PTP-PEST and adaptor proteins p130cas and Crk |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue=2 |pages=H710–21 | issn = 0363-6135| pmid = 12714323 |doi = 10.1152/ajpheart.01127.2002 |s2cid=42587789 }}{{cite journal |last=Garton |first=A J |author2=Burnham M R |author3=Bouton A H |author4=Tonks N K |date=Aug 1997 |title=Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition |journal=Oncogene |volume=15 |issue=8 |pages=877–85 | issn = 0950-9232| pmid = 9285683 |doi = 10.1038/sj.onc.1201279 |doi-access=free }}{{cite journal |last=Côté |first=J F |author2=Charest A |author3=Wagner J |author4=Tremblay M L |date=Sep 1998 |title=Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model |journal=Biochemistry |volume=37 |issue=38 |pages=13128–37 | issn = 0006-2960| pmid = 9748319 |doi = 10.1021/bi981259l }}{{cite journal |last=Garton |first=A J |author2=Flint A J |author3=Tonks N K |date=Nov 1996 |title=Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST |journal=Mol. Cell. Biol. |volume=16 |issue=11 |pages=6408–18 | issn = 0270-7306| pmid = 8887669 |pmc=231642 |doi=10.1128/MCB.16.11.6408 }} Grb2,{{cite journal |last=Charest |first=A |author2=Wagner J |author3=Kwan M |author4=Tremblay M L |date=Apr 1997 |title=Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2 |journal=Oncogene |volume=14 |issue=14 |pages=1643–51 | issn = 0950-9232| pmid = 9135065 |doi = 10.1038/sj.onc.1201008 |doi-access=free }} PSTPIP1,{{cite journal |last=Dowbenko |first=D |author2=Spencer S |author3=Quan C |author4=Lasky L A |date=Jan 1998 |title=Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein |journal=J. Biol. Chem. |volume=273 |issue=2 |pages=989–96 | issn = 0021-9258| pmid = 9422760 |doi=10.1074/jbc.273.2.989 |doi-access=free }} TGFB1I1,{{cite journal |last=Nishiya |first=N |author2=Iwabuchi Y |author3=Shibanuma M |author4=Côté J F |author5=Tremblay M L |author6=Nose K |date=Apr 1999 |title=Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain |journal=J. Biol. Chem. |volume=274 |issue=14 |pages=9847–53 | issn = 0021-9258| pmid = 10092676 |doi=10.1074/jbc.274.14.9847 |doi-access=free }} Paxillin{{cite journal |last=Shen |first=Y |author2=Lyons P |author3=Cooley M |author4=Davidson D |author5=Veillette A |author6=Salgia R |author7=Griffin J D |author8=Schaller M D |date=Jan 2000 |title=The noncatalytic domain of protein-tyrosine phosphatase-PEST targets paxillin for dephosphorylation in vivo |journal=J. Biol. Chem. |volume=275 |issue=2 |pages=1405–13 | issn = 0021-9258| pmid = 10625692 |doi=10.1074/jbc.275.2.1405 |doi-access=free }}{{cite journal |last=Côté |first=J F |author2=Turner C E |author3=Tremblay M L |date=Jul 1999 |title=Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST |journal=J. Biol. Chem. |volume=274 |issue=29 |pages=20550–60 | issn = 0021-9258| pmid = 10400685 |doi=10.1074/jbc.274.29.20550 |doi-access=free }}{{cite journal |last=Shen |first=Y |author2=Schneider G |author3=Cloutier J F |author4=Veillette A |author5=Schaller M D |date=Mar 1998 |title=Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin |journal=J. Biol. Chem. |volume=273 |issue=11 |pages=6474–81 | issn = 0021-9258| pmid = 9497381 |doi=10.1074/jbc.273.11.6474 |doi-access=free }} and SHC1.{{cite journal |last=Habib |first=T |author2=Herrera R |author3=Decker S J |date=Oct 1994 |title=Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase |journal=J. Biol. Chem. |volume=269 |issue=41 |pages=25243–6 |doi=10.1016/S0021-9258(18)47237-7 | issn = 0021-9258| pmid = 7929214 |doi-access=free }}{{cite journal |last=Charest |first=A |author2=Wagner J |author3=Jacob S |author4=McGlade C J |author5=Tremblay M L |date=Apr 1996 |title=Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity |journal=J. Biol. Chem. |volume=271 |issue=14 |pages=8424–9 | issn = 0021-9258| pmid = 8626541 | doi=10.1074/jbc.271.14.8424|doi-access=free }}

References

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Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Takekawa M, Itoh F, Hinoda Y, etal |title=Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 1223–30 |year= 1993 |pmid= 1472029 |doi=10.1016/0006-291X(92)92335-U }}
  • {{cite journal |vauthors=Yi T, Cleveland JL, Ihle JN |title=Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification |journal=Blood |volume=78 |issue= 9 |pages= 2222–8 |year= 1991 |pmid= 1932742 |doi= 10.1182/blood.V78.9.2222.2222|doi-access=free }}
  • {{cite journal |vauthors=Garton AJ, Tonks NK |title=PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation |journal=EMBO J. |volume=13 |issue= 16 |pages= 3763–71 |year= 1994 |pmid= 7520867 |doi= 10.1002/j.1460-2075.1994.tb06687.x| pmc=395289 }}
  • {{cite journal |vauthors=Habib T, Herrera R, Decker SJ |title=Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase |journal=J. Biol. Chem. |volume=269 |issue= 41 |pages= 25243–6 |year= 1994 |doi=10.1016/S0021-9258(18)47237-7 |pmid= 7929214 |doi-access=free }}
  • {{cite journal |vauthors=Yang Q, Co D, Sommercorn J, Tonks NK |title=Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase |journal=J. Biol. Chem. |volume=268 |issue= 23 |pages= 17650 |year= 1993 |doi=10.1016/S0021-9258(19)85383-8 |pmid= 8349645 |doi-access=free }}
  • {{cite journal |vauthors=Yang Q, Co D, Sommercorn J, Tonks NK |title=Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase |journal=J. Biol. Chem. |volume=268 |issue= 9 |pages= 6622–8 |year= 1993 |doi=10.1016/S0021-9258(18)53296-8 |pmid= 8454633 |doi-access=free }}
  • {{cite journal |vauthors=Charest A, Wagner J, Jacob S, etal |title=Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8424–9 |year= 1996 |pmid= 8626541 |doi= 10.1074/jbc.271.14.8424|doi-access=free }}
  • {{cite journal |vauthors=Garton AJ, Flint AJ, Tonks NK |title=Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST |journal=Mol. Cell. Biol. |volume=16 |issue= 11 |pages= 6408–18 |year= 1996 |pmid= 8887669 |doi= 10.1128/MCB.16.11.6408| pmc=231642 }}
  • {{cite journal |vauthors=Charest A, Wagner J, Kwan M, Tremblay ML |title=Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2 |journal=Oncogene |volume=14 |issue= 14 |pages= 1643–51 |year= 1997 |pmid= 9135065 |doi= 10.1038/sj.onc.1201008 |doi-access= free }}
  • {{cite journal |vauthors=Garton AJ, Burnham MR, Bouton AH, Tonks NK |title=Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition |journal=Oncogene |volume=15 |issue= 8 |pages= 877–85 |year= 1997 |pmid= 9285683 |doi= 10.1038/sj.onc.1201279 |doi-access= free }}
  • {{cite journal |vauthors=Dowbenko D, Spencer S, Quan C, Lasky LA |title=Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 989–96 |year= 1998 |pmid= 9422760 |doi=10.1074/jbc.273.2.989 |doi-access=free }}
  • {{cite journal |vauthors=Shen Y, Schneider G, Cloutier JF, etal |title=Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6474–81 |year= 1998 |pmid= 9497381 |doi=10.1074/jbc.273.11.6474 |doi-access=free }}
  • {{cite journal |vauthors=Côté JF, Charest A, Wagner J, Tremblay ML |title=Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model |journal=Biochemistry |volume=37 |issue= 38 |pages= 13128–37 |year= 1998 |pmid= 9748319 |doi= 10.1021/bi981259l }}
  • {{cite journal |vauthors=Wu Y, Dowbenko D, Lasky LA |title=PSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphatase |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30487–96 |year= 1998 |pmid= 9804817 |doi=10.1074/jbc.273.46.30487 |doi-access=free }}
  • {{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The |doi-access=free }}
  • {{cite journal |vauthors=Li J, Nishizawa K, An W, etal |title=A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion |journal=EMBO J. |volume=17 |issue= 24 |pages= 7320–36 |year= 1999 |pmid= 9857189 |doi= 10.1093/emboj/17.24.7320 | pmc=1171078 }}
  • {{cite journal |vauthors=Garton AJ, Tonks NK |title=Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3811–8 |year= 1999 |pmid= 9920935 |doi=10.1074/jbc.274.6.3811 |doi-access=free }}
  • {{cite journal |vauthors=Angers-Loustau A, Côté JF, Charest A, etal |title=Protein Tyrosine Phosphatase-PEST Regulates Focal Adhesion Disassembly, Migration, and Cytokinesis in Fibroblasts |journal=J. Cell Biol. |volume=144 |issue= 5 |pages= 1019–31 |year= 1999 |pmid= 10085298 |doi=10.1083/jcb.144.5.1019 | pmc=2148201 }}
  • {{cite journal |vauthors=Nishiya N, Iwabuchi Y, Shibanuma M, etal |title=Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9847–53 |year= 1999 |pmid= 10092676 |doi=10.1074/jbc.274.14.9847 |doi-access=free }}

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{{Protein tyrosine phosphatases}}