PTPN4

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.

PTPN4 has been shown to interact with GRID2.{{cite journal | vauthors = Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T | title = The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits | journal = J. Biol. Chem. | volume = 275 | issue = 21 | pages = 16167–73 | date = May 2000 | pmid = 10748123 | doi = 10.1074/jbc.M909302199 | doi-access = free }}

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• {{cite journal | vauthors = Gu M, Majerus PW | title = The properties of the protein tyrosine phosphatase PTPMEG | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27751–9 | year = 1996 | pmid = 8910369 | doi = 10.1074/jbc.271.44.27751 | doi-access = free }}
• {{cite journal | vauthors = Gu M, Meng K, Majerus PW | title = The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 23 | pages = 12980–5 | year = 1996 | pmid = 8917530 | pmc = 24032 | doi = 10.1073/pnas.93.23.12980 | bibcode = 1996PNAS...9312980G | doi-access = free }}
• {{cite journal | vauthors = Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T | title = The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits | journal = J. Biol. Chem. | volume = 275 | issue = 21 | pages = 16167–73 | year = 2000 | pmid = 10748123 | doi = 10.1074/jbc.M909302199 | doi-access = free }}
• {{cite journal | vauthors = Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T | title = Subcellular localization of intracellular protein tyrosine phosphatases in T cells | journal = Eur. J. Immunol. | volume = 30 | issue = 8 | pages = 2412–21 | year = 2000 | pmid = 10940933 | doi = 10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J | s2cid = 8132613 }}
• {{cite journal | vauthors = Park KW, Lee EJ, Lee S, Lee JE, Choi E, Kim BJ, Hwang R, Park KA, Baik J | title = Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG | journal = Gene | volume = 257 | issue = 1 | pages = 45–55 | year = 2001 | pmid = 11054567 | doi = 10.1016/S0378-1119(00)00351-6 }}
• {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }}

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• {{PDBe-KB2|P29074|Human Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)}}

{{PDB Gallery|geneid=5775}}

{{Protein tyrosine phosphatases}}

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