PTPRA

The protein encoded by this gene is a member of the receptor tyrosine phosphatases (RTP), a family of protein tyrosine phosphatases. RTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This RTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type RTP. This RTP has been shown to dephosphorylate and activate Src family tyrosine kinases,{{cite journal|vauthors=den Hertog J, Pals CE, Peppelenbosch MP, Tertoolen LG, de Laat SW, Kruijer W |title=Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation|journal= EMBO Journal|year=1993|volume=12|issue=10|pages=3789–98 |doi=10.1002/j.1460-2075.1993.tb06057.x|pmid=7691597|pmc=413662|doi-access=free}} and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

PTPRA has been shown to interact with Grb2{{cite journal | vauthors = den Hertog J, Hunter T | title = Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains | journal = EMBO J. | volume = 15 | issue = 12 | pages = 3016–27 | date = June 1996 | pmid = 8670803 | pmc = 450243 | doi=10.1002/j.1460-2075.1996.tb00665.x}}{{cite journal | vauthors = den Hertog J, Tracy S, Hunter T | title = Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo | journal = EMBO J. | volume = 13 | issue = 13 | pages = 3020–32 | date = July 1994 | pmid = 7518772 | pmc = 395191 | doi=10.1002/j.1460-2075.1994.tb06601.x}}{{cite journal | vauthors = Zheng XM, Resnick RJ, Shalloway D | title = Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation | journal = J. Biol. Chem. | volume = 277 | issue = 24 | pages = 21922–9 | date = June 2002 | pmid = 11923305 | doi = 10.1074/jbc.M201394200 | pmc = 5641391 | doi-access = free }} and KCNA2.{{cite journal | vauthors = Tsai W, Morielli AD, Cachero TG, Peralta EG | title = Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity | journal = EMBO J. | volume = 18 | issue = 1 | pages = 109–18 | date = January 1999 | pmid = 9878055 | pmc = 1171107 | doi = 10.1093/emboj/18.1.109 }}

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• {{cite journal | vauthors = Zheng XM, Wang Y, Pallen CJ | title = Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase | journal = Nature | volume = 359 | issue = 6393 | pages = 336–9 | year = 1992 | pmid = 1383828 | doi = 10.1038/359336a0 | bibcode = 1992Natur.359..336Z | s2cid = 1283722 }}
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• {{cite journal | vauthors = Ohagi S, Nishi M, Steiner DF | title = Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide) | journal = Nucleic Acids Res. | volume = 18 | issue = 23 | pages = 7159 | year = 1991 | pmid = 2175890 | pmc = 332805 | doi = 10.1093/nar/18.23.7159 }}
• {{cite journal | vauthors = den Hertog J, Tracy S, Hunter T | title = Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo | journal = EMBO J. | volume = 13 | issue = 13 | pages = 3020–32 | year = 1994 | pmid = 7518772 | pmc = 395191 | doi = 10.1002/j.1460-2075.1994.tb06601.x}}
• {{cite journal | vauthors = den Hertog J, Pals CE, Peppelenbosch MP, Tertoolen LG, de Laat SW, Kruijer W | title = Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation | journal = EMBO J. | volume = 12 | issue = 10 | pages = 3789–98 | year = 1993 | pmid = 7691597 | pmc = 413662 | doi = 10.1002/j.1460-2075.1993.tb06057.x}}
• {{cite journal | vauthors = Stover DR, Furet P, Lydon NB | title = Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain | journal = J. Biol. Chem. | volume = 271 | issue = 21 | pages = 12481–7 | year = 1996 | pmid = 8647855 | doi = 10.1074/jbc.271.21.12481 | doi-access = free }}
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• {{cite journal | vauthors = Lim KL, Lai DS, Kalousek MB, Wang Y, Pallen CJ | title = Kinetic analysis of two closely related receptor-like protein-tyrosine-phosphatases, PTP alpha and PTP epsilon | journal = Eur. J. Biochem. | volume = 245 | issue = 3 | pages = 693–700 | year = 1997 | pmid = 9183007 | doi = 10.1111/j.1432-1033.1997.00693.x | doi-access = free }}
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• {{cite journal | vauthors = Feito MJ, Bragardo M, Buonfiglio D, Bonissoni S, Bottarel F, Malavasi F, Dianzani U | title = gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules | journal = Int. Immunol. | volume = 9 | issue = 8 | pages = 1141–7 | year = 1997 | pmid = 9263011 | doi = 10.1093/intimm/9.8.1141 | doi-access = free }}
• {{cite journal | vauthors = Norris K, Norris F, Kono DH, Vestergaard H, Pedersen O, Theofilopoulos AN, Møller NP | title = Expression of protein-tyrosine phosphatases in the major insulin target tissues | journal = FEBS Lett. | volume = 415 | issue = 3 | pages = 243–8 | year = 1997 | pmid = 9357975 | doi = 10.1016/S0014-5793(97)01133-2 | s2cid = 9414519 | doi-access = | bibcode = 1997FEBSL.415..243N }}
• {{cite journal | vauthors = Bhandari V, Lim KL, Pallen CJ | title = Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 8691–8 | year = 1998 | pmid = 9535845 | doi = 10.1074/jbc.273.15.8691 | doi-access = free }}
• {{cite journal | vauthors = Harder KW, Moller NP, Peacock JW, Jirik FR | title = Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion | journal = J. Biol. Chem. | volume = 273 | issue = 48 | pages = 31890–900 | year = 1998 | pmid = 9822658 | doi = 10.1074/jbc.273.48.31890 | doi-access =free }}

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{{PDB Gallery|geneid=5786}}

{{Protein tyrosine phosphatases}}

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