PTPRCAP
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{cs1 config|name-list-style=vanc}}
{{Infobox_gene}}
Protein tyrosine phosphatase receptor type C-associated protein is an enzyme that in humans is encoded by the PTPRCAP gene.{{cite web | title = Entrez Gene: PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5790| accessdate = }}
The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | author=Schraven B |title=LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 29102–11 |year= 1994 |pmid= 7961877 | author2=Schoenhaut D | author3=Bruyns E | last4=Koretzky | first4=G | last5=Eckerskorn | first5=C | last6=Wallich | first6=R | last7=Kirchgessner | first7=H | last8=Sakorafas | first8=P | last9=Labkovsky | first9=B |doi=10.1016/S0021-9258(19)62018-1 |doi-access=free }}
- {{cite journal | author=Bruyns E |title=Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45 |journal=J. Biol. Chem. |volume=270 |issue= 52 |pages= 31372–6 |year= 1996 |pmid= 8537410 |doi=10.1074/jbc.270.52.31372 | author2=Hendricks-Taylor LR | author3=Meuer S | last4=Koretzky | first4=GA | last5=Schraven | first5=B |doi-access=free }}
- {{cite journal | author=Bruyns E |title=Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes |journal=Genomics |volume=38 |issue= 1 |pages= 79–83 |year= 1997 |pmid= 8954783 |doi= 10.1006/geno.1996.0595 | author2=Mincheva A | author3=Bruyns RM | last4=Kirchgessner | first4=Henning | last5=Weitz | first5=Sandra | last6=Lichter | first6=Peter | last7=Meuer | first7=Stefan | last8=Schraven | first8=Burkhart }}
- {{cite journal | author=Kung C |title=CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction |journal=Eur. J. Immunol. |volume=29 |issue= 12 |pages= 3951–5 |year= 2000 |pmid= 10602003 |doi=10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9 | author2=Okumura M | author3=Seavitt JR | last4=Noll | first4=Michelle E. | last5=White | first5=Lynn S. | last6=Pingel | first6=Jeanette T. | last7=Thomas | first7=Matthew L. | doi-access= |s2cid=4962507 }}
- {{cite journal | author=Woods ML |title=A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor |journal=EMBO J. |volume=20 |issue= 6 |pages= 1232–44 |year= 2001 |pmid= 11250890 |doi= 10.1093/emboj/20.6.1232 | pmc=145515 | author2=Kivens WJ | author3=Adelsman MA | last4=Qiu | first4=Yun | last5=August | first5=Avery | last6=Shimizu | first6=Yoji }}
- {{cite journal | author=Kirchgessner H |title=The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269–84 |year= 2001 |pmid= 11390434 |doi=10.1084/jem.193.11.1269 | pmc=2193385 | author2=Dietrich J | author3=Scherer J | last4=Isomaki | first4=P. | last5=Korinek | first5=V. | last6=Hilgert | first6=I. | last7=Bruyns | first7=E. | last8=Leo | first8=A. | last9=Cope | first9=A. P. }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Vogel A, Strassburg CP, Manns MP |title=77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link |journal=Genes Immun. |volume=4 |issue= 1 |pages= 79–81 |year= 2003 |pmid= 12595907 |doi= 10.1038/sj.gene.6363918 |doi-access= |s2cid=19853676 }}
- {{cite journal | author=Cocco E |title=PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients |journal=J. Neurol. |volume=251 |issue= 9 |pages= 1085–8 |year= 2004 |pmid= 15372250 |doi= 10.1007/s00415-004-0485-1 | author2=Murru MR | author3=Melis C | last4=Schirru | first4=Lucia | last5=Solla | first5=Elisabetta | last6=Lai | first6=Marina | last7=Rolesu | first7=Marcella | last8=Marrosu | first8=Mariagiovanna |s2cid=35718298 }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{refend}}
{{protein-stub}}