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PTPRH

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.{{cite journal | vauthors = Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C| title = Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers | journal = J Biol Chem | volume = 269 | issue = 3 | pages = 2075–81 |date=Feb 1994 | doi = 10.1016/S0021-9258(17)42137-5 | pmid = 8294459 |display-authors=etal| doi-access = free }}{{cite web | title = Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5794}}

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.

References

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Further reading

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  • {{cite journal |vauthors=Noguchi T, Tsuda M, Takeda H, etal |title=Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15216–24 |year= 2001 |pmid= 11278335 |doi= 10.1074/jbc.M007208200 |doi-access= free }}
  • {{cite journal |vauthors=Marneros AG, Mehenni H, Reichenberger E, etal |title=Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3–4 |pages= 213–6 |year= 2001 |pmid= 11435690 |doi=10.1159/000056905 |s2cid=20187527 }}
  • {{cite journal |vauthors=Takada T, Noguchi T, Inagaki K, etal |title=Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1 |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34359–66 |year= 2002 |pmid= 12101188 |doi= 10.1074/jbc.M206541200 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Nagano H, Noguchi T, Inagaki K, etal |title=Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma |journal=Oncogene |volume=22 |issue= 30 |pages= 4656–63 |year= 2003 |pmid= 12879010 |doi= 10.1038/sj.onc.1206588 |doi-access= |s2cid=2707273 }}
  • {{cite journal |vauthors=Pasquali C, Curchod ML, Wälchli S, etal |title=Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor |journal=Mol. Endocrinol. |volume=17 |issue= 11 |pages= 2228–39 |year= 2004 |pmid= 12907755 |doi= 10.1210/me.2003-0011 |doi-access= free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}

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{{Protein tyrosine phosphatases}}

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