PTPRZ1

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.

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• {{cite journal | vauthors = Krueger NX, Saito H | title = A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 16 | pages = 7417–21 | year = 1992 | pmid = 1323835 | pmc = 49721 | doi = 10.1073/pnas.89.16.7417 | bibcode = 1992PNAS...89.7417K | doi-access = free }}
• {{cite journal | vauthors = Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J | title = Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 18 | pages = 7000–4 | year = 1990 | pmid = 2169617 | pmc = 54670 | doi = 10.1073/pnas.87.18.7000 | bibcode = 1990PNAS...87.7000K | doi-access = free }}
• {{cite journal | vauthors = Krueger NX, Streuli M, Saito H | title = Structural diversity and evolution of human receptor-like protein tyrosine phosphatases | journal = EMBO J. | volume = 9 | issue = 10 | pages = 3241–52 | year = 1990 | pmid = 2170109 | pmc = 552056 | doi = 10.1002/j.1460-2075.1990.tb07523.x}}
• {{cite journal | vauthors = Morton SM, Veile RA, Helms C, Lee M, Kuo WL, Gray J, Donis-Keller H | title = Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s | journal = Genomics | volume = 46 | issue = 3 | pages = 491–4 | year = 1998 | pmid = 9441757 | doi = 10.1006/geno.1997.5051 }}
• {{cite journal | vauthors = Onyango P, Lubyova B, Gardellin P, Kurzbauer R, Weith A | title = Molecular cloning and expression analysis of five novel genes in chromosome 1p36 | journal = Genomics | volume = 50 | issue = 2 | pages = 187–98 | year = 1998 | pmid = 9653645 | doi = 10.1006/geno.1997.5186 | doi-access = free }}
• {{cite journal | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1999 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 | doi-access = free | last1 = Sanger Centre | first1 = The | last2 = Washington University Genome Sequencing Cente | first2 = The }}
• {{cite journal | vauthors = Maeda N, Ichihara-Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M | title = A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta | journal = J. Biol. Chem. | volume = 274 | issue = 18 | pages = 12474–9 | year = 1999 | pmid = 10212223 | doi = 10.1074/jbc.274.18.12474 | doi-access = free }}
• {{cite journal | vauthors = Kawachi H, Tamura H, Watakabe I, Shintani T, Maeda N, Noda M | title = Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family | journal = Brain Res. Mol. Brain Res. | volume = 72 | issue = 1 | pages = 47–54 | year = 1999 | pmid = 10521598 | doi = 10.1016/S0169-328X(99)00204-1 }}
• {{cite journal | vauthors = Meng K, Rodriguez-Peña A, Dimitrov T, Chen W, Yamin M, Noda M, Deuel TF | title = Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 6 | pages = 2603–8 | year = 2000 | pmid = 10706604 | pmc = 15975 | doi = 10.1073/pnas.020487997 | bibcode = 2000PNAS...97.2603M | doi-access = free }}
• {{cite journal | vauthors = Kawachi H, Fujikawa A, Maeda N, Noda M | title = Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 12 | pages = 6593–8 | year = 2001 | pmid = 11381105 | pmc = 34398 | doi = 10.1073/pnas.041608698 | bibcode = 2001PNAS...98.6593K | doi-access = free }}
• {{cite journal | vauthors = Thomaidou D, Coquillat D, Meintanis S, Noda M, Rougon G, Matsas R | title = Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells | journal = J. Neurochem. | volume = 78 | issue = 4 | pages = 767–78 | year = 2001 | pmid = 11520897 | doi = 10.1046/j.1471-4159.2001.00454.x | s2cid = 24682985 | doi-access = }}
• {{cite journal | vauthors = Harroch S, Furtado GC, Brueck W, Rosenbluth J, Lafaille J, Chao M, Buxbaum JD, Schlessinger J | title = A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions | journal = Nat. Genet. | volume = 32 | issue = 3 | pages = 411–4 | year = 2002 | pmid = 12355066 | doi = 10.1038/ng1004 | s2cid = 19800079 }}
• {{cite journal | vauthors = Müller S, Kunkel P, Lamszus K, Ulbricht U, Lorente GA, Nelson AM, von Schack D, Chin DJ, Lohr SC, Westphal M, Melcher T | title = A role for receptor tyrosine phosphatase zeta in glioma cell migration | journal = Oncogene | volume = 22 | issue = 43 | pages = 6661–8 | year = 2003 | pmid = 14555979 | doi = 10.1038/sj.onc.1206763 | doi-access = free }}
• {{cite journal | vauthors = Bonora E, Lamb JA, Barnby G, Sykes N, Moberly T, Beyer KS, Klauck SM, Poustka F, Bacchelli E, Blasi F, Maestrini E, Battaglia A, Haracopos D, Pedersen L, Isager T, Eriksen G, Viskum B, Sorensen EU, Brondum-Nielsen K, Cotterill R, van Engeland H, de Jonge M, Kemner C, Steggehuis K, Scherpenisse M, Rutter M, Bolton PF, Parr JR, Poustka A, Bailey AJ, Monaco AP | title = Mutation screening and association analysis of six candidate genes for autism on chromosome 7q | journal = Eur. J. Hum. Genet. | volume = 13 | issue = 2 | pages = 198–207 | year = 2005 | pmid = 15523497 | doi = 10.1038/sj.ejhg.5201315 | doi-access = free }}
• {{cite journal | vauthors = Polykratis A, Katsoris P, Courty J, Papadimitriou E | title = Characterization of heparin affin regulatory peptide signaling in human endothelial cells | journal = J. Biol. Chem. | volume = 280 | issue = 23 | pages = 22454–61 | year = 2005 | pmid = 15797857 | doi = 10.1074/jbc.M414407200 | doi-access = free }}
• {{cite journal | vauthors = Wang V, Davis DA, Haque M, Huang LE, Yarchoan R | title = Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells | journal = Cancer Res. | volume = 65 | issue = 8 | pages = 3299–306 | year = 2005 | pmid = 15833863 | doi = 10.1158/0008-5472.CAN-04-4130 | doi-access = }}
• {{cite journal|author-link8=Timothy Cloughesy|author-link10=Paul S. Mischel | vauthors = Lu KV, Jong KA, Kim GY, Singh J, Dia EQ, Yoshimoto K, Wang MY, Cloughesy TF, Nelson SF, Mischel PS | title = Differential induction of glioblastoma migration and growth by two forms of pleiotrophin | journal = J. Biol. Chem. | volume = 280 | issue = 29 | pages = 26953–64 | year = 2005 | pmid = 15908427 | doi = 10.1074/jbc.M502614200 | doi-access = free }}

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{{Protein tyrosine phosphatases}}

{{Esterases}}

{{Enzymes}}

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Category:EC 3.1.3

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