Pachyderma

{{short description|Thickening of the skin}}

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Pachyderma, or pachydermia, is the thickening of skin like that of a pachyderm (a tough-skinned animal such as an elephant, rhinoceros, tapir or hippopotamus).{{cite web |url=http://www.medterms.com/script/main/art.asp?articlekey=32876 |title= Definition of Pachyderma |accessdate=2008-04-06 |publisher= MedicineNet.com }} It occurs in the condition pachydermoperiostosis, an autosomal genetic disorder.{{cite journal |last1=Zhang |first1=Zeng |last2=Zhang |first2=Changqing |last3=Zhang |first3=Zhenlin |title=Primary hypertrophic osteoarthropathy: an update |journal=Front Med |date=2013 |volume=7 |issue=1 |pages=60–4 |doi=10.1007/s11684-013-0246-6|pmid=23345113 |s2cid=19703307 }} It can also occur in acromegaly, elephantiasis, and podoconiosis.{{Cite web|url=http://www.ufrgs.br/imunovet/molecular_immunology/pathohomotissueskin.html|title=Homo sapiens diseases — Cutaneous apparatus and subcutaneous tissue|website=www.ufrgs.br|access-date=2020-03-04}} The adjective pachydermatous is used to describe skin showing symptoms of this condition.{{Cite web|url=https://www.merriam-webster.com/dictionary/pachydermatous|title=Definition of PACHYDERMATOUS|website=www.merriam-webster.com|language=en|access-date=2020-03-04}}