Palazzuolo sul Senio

{{Infobox Italian comune

| name = Palazzuolo sul Senio

| official_name = Comune di Palazzuolo sul Senio

| native_name = Palazzuolo di Romagna

| image_skyline = Palazzuolo sul Senio - Lungofiume (Senio).jpg

| imagesize =

| image_alt =

| image_caption = Overview of the riverfront (Senio River)

| image_shield = Palazzuolo sul Senio -Stemma.png

| coordinates = {{coord|44|7|N|11|33|E|type:city(1,257)_region:IT|display=inline}}

| coordinates_footnotes =

| region = Tuscany

| metropolitan_city = Florence (FI)

| frazioni = Campanara, Casetta di Tiara, Mantigno, Misileo, Piedimonte, Quadalto, Salecchio, Visano

| mayor = Marco Bottino

| area_footnotes =

| area_total_km2 = 109.11

| population_footnotes = All demographics and other statistics: Italian statistical institute Istat.

| population_total = 1081

| population_as_of = 1 January 2024

| pop_density_footnotes =

| population_demonym = Palazzuolesi

| elevation_footnotes =

| elevation_m = 437

| twin1 =

| twin1_country =

|istat=048031| saint = St. Stephen

| day = December 26

| postal_code = 50035

| area_code = 055

| website = {{official website|http://www.comune.palazzuolo-sul-senio.fi.it/}}

| footnotes =

}}

Palazzuolo sul Senio (formerly Palazzolo di Romagna; Romagnolo: Palazol) is a comune (municipality) in the Metropolitan City of Florence in the Italian region Tuscany, located about {{convert|45|km|mi}} northeast of Florence.

Palazzuolo sul Senio borders the following municipalities: Borgo San Lorenzo, Brisighella, Casola Valsenio, Castel del Rio, Firenzuola, Marradi.

Since 2018, it has been designated as one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").{{cite web|url=https://borghipiubelliditalia.it/toscana/|title=Toscana|access-date=1 August 2023|language=it}}