Paul Mischel

Mischel was born on July 13, 1962. After losing his father to cancer, he became committed to a career in cancer research. He attended the University of Pennsylvania and received his M.D. from Cornell University Medical College in 1991, graduating Alpha Omega Alpha. Mischel completed residency training in Anatomic Pathology and Neuropathology at UCLA, followed by post-doctoral research training with Louis Reichardt at HHMI-UCSF. Mischel joined the faculty of UCLA in 1998. In August 2012, he was recruited to the Ludwig Institute for Cancer Research, San Diego and UCSD. In 2021, he joined Stanford University School of Medicine, where he currently serves as a Professor and Vice Chair of Research for the Department of Pathology and Institute Scholar of ChEM-H. Mischel leads the team of eDyNAmiC project.

Mischel’s research has demonstrated a central role for ecDNA in cancer. Studies he has led, published in a series of papers in Nature and Science, has provided a mechanistic understanding of the molecular basis of intratumoral genetic heterogeneity, accelerated evolution and treatment resistance driven by ecDNA oncogene amplification. His team’s research has shown that ecDNA occurs in close to 20% of all solid cancers, of women and men, children and adults, that it is associated with poor outcome for patients. This research has revealed clinical implications and underlying molecular mechanisms of ecDNA in cancer development and progression, suggesting the potential for future ecDNA-directed cancer treatments.{{Cite journal |last1=Nathanson |first1=David A. |last2=Gini |first2=Beatrice |last3=Mottahedeh |first3=Jack |last4=Visnyei |first4=Koppany |last5=Koga |first5=Tomoyuki |last6=Gomez |first6=German |last7=Eskin |first7=Ascia |last8=Hwang |first8=Kiwook |last9=Wang |first9=Jun |last10=Masui |first10=Kenta |last11=Paucar |first11=Andres |last12=Yang |first12=Huijun |last13=Ohashi |first13=Minori |last14=Zhu |first14=Shaojun |last15=Wykosky |first15=Jill |date=2014-01-03 |title=Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA |journal=Science |language=en |volume=343 |issue=6166 |pages=72–76 |doi=10.1126/science.1241328 |issn=0036-8075 |pmc=4049335 |pmid=24310612|bibcode=2014Sci...343...72N }}{{Cite journal |last1=Turner |first1=Kristen M. |last2=Deshpande |first2=Viraj |last3=Beyter |first3=Doruk |last4=Koga |first4=Tomoyuki |last5=Rusert |first5=Jessica |last6=Lee |first6=Catherine |last7=Li |first7=Bin |last8=Arden |first8=Karen |last9=Ren |first9=Bing |last10=Nathanson |first10=David A. |last11=Kornblum |first11=Harley I. |last12=Taylor |first12=Michael D. |last13=Kaushal |first13=Sharmeela |last14=Cavenee |first14=Webster K. |last15=Wechsler-Reya |first15=Robert |date=March 2017 |title=Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity |journal=Nature |language=en |volume=543 |issue=7643 |pages=122–125 |doi=10.1038/nature21356 |pmid=28178237 |issn=1476-4687|pmc=5334176 |bibcode=2017Natur.543..122T }}{{Cite journal |last1=Wu |first1=Sihan |last2=Turner |first2=Kristen M. |last3=Nguyen |first3=Nam |last4=Raviram |first4=Ramya |last5=Erb |first5=Marcella |last6=Santini |first6=Jennifer |last7=Luebeck |first7=Jens |last8=Rajkumar |first8=Utkrisht |last9=Diao |first9=Yarui |last10=Li |first10=Bin |last11=Zhang |first11=Wenjing |last12=Jameson |first12=Nathan |last13=Corces |first13=M. Ryan |last14=Granja |first14=Jeffrey M. |last15=Chen |first15=Xingqi |date=November 2019 |title=Circular ecDNA promotes accessible chromatin and high oncogene expression |journal=Nature |language=en |volume=575 |issue=7784 |pages=699–703 |doi=10.1038/s41586-019-1763-5 |pmid=31748743 |issn=1476-4687|pmc=7094777 |bibcode=2019Natur.575..699W }}{{Cite journal |last1=Kim |first1=Hoon |last2=Kim |first2=Soyeon |last3=Wade |first3=Taylor |last4=Yeo |first4=Eunchae |last5=Lipsa |first5=Anuja |last6=Golebiewska |first6=Anna |last7=Johnson |first7=Kevin C. |last8=An |first8=Sepil |last9=Ko |first9=Junyong |last10=Nam |first10=Yoonjoo |last11=Lee |first11=Hwa Yeon |last12=Kang |first12=Seunghyun |last13=Chung |first13=Heesuk |last14=Niclou |first14=Simone P. |last15=Moon |first15=Hyo-Eun |date=November 2024 |title=Mapping extrachromosomal DNA amplifications during cancer progression |journal=Nature Genetics |language=en |volume=56 |issue=11 |pages=2447–2454 |doi=10.1038/s41588-024-01949-7 |pmid=39402156 |issn=1546-1718|pmc=11549044 }}{{Cite journal |last1=Hung |first1=King L. |last2=Yost |first2=Kathryn E. |last3=Xie |first3=Liangqi |last4=Shi |first4=Quanming |last5=Helmsauer |first5=Konstantin |last6=Luebeck |first6=Jens |last7=Schöpflin |first7=Robert |last8=Lange |first8=Joshua T. |last9=Chamorro González |first9=Rocío |last10=Weiser |first10=Natasha E. |last11=Chen |first11=Celine |last12=Valieva |first12=Maria E. |last13=Wong |first13=Ivy Tsz-Lo |last14=Wu |first14=Sihan |last15=Dehkordi |first15=Siavash R. |date=December 2021 |title=ecDNA hubs drive cooperative intermolecular oncogene expression |journal=Nature |language=en |volume=600 |issue=7890 |pages=731–736 |doi=10.1038/s41586-021-04116-8 |pmid=34819668 |issn=1476-4687|pmc=9126690 |bibcode=2021Natur.600..731H }}{{Cite journal |last1=Bergstrom |first1=Erik N. |last2=Luebeck |first2=Jens |last3=Petljak |first3=Mia |last4=Khandekar |first4=Azhar |last5=Barnes |first5=Mark |last6=Zhang |first6=Tongwu |last7=Steele |first7=Christopher D. |last8=Pillay |first8=Nischalan |last9=Landi |first9=Maria Teresa |last10=Bafna |first10=Vineet |last11=Mischel |first11=Paul S. |last12=Harris |first12=Reuben S. |last13=Alexandrov |first13=Ludmil B. |date=February 2022 |title=Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA |journal=Nature |language=en |volume=602 |issue=7897 |pages=510–517 |doi=10.1038/s41586-022-04398-6 |pmid=35140399 |issn=1476-4687|pmc=8850194 |bibcode=2022Natur.602..510B }}{{Cite journal |last1=Lange |first1=Joshua T. |last2=Rose |first2=John C. |last3=Chen |first3=Celine Y. |last4=Pichugin |first4=Yuriy |last5=Xie |first5=Liangqi |last6=Tang |first6=Jun |last7=Hung |first7=King L. |last8=Yost |first8=Kathryn E. |last9=Shi |first9=Quanming |last10=Erb |first10=Marcella L. |last11=Rajkumar |first11=Utkrisht |last12=Wu |first12=Sihan |last13=Taschner-Mandl |first13=Sabine |last14=Bernkopf |first14=Marie |last15=Swanton |first15=Charles |date=October 2022 |title=The evolutionary dynamics of extrachromosomal DNA in human cancers |journal=Nature Genetics |language=en |volume=54 |issue=10 |pages=1527–1533 |doi=10.1038/s41588-022-01177-x |pmid=36123406 |issn=1546-1718|pmc=9534767 }}{{Cite journal |last1=Hung |first1=King L. |last2=Luebeck |first2=Jens |last3=Dehkordi |first3=Siavash R. |last4=Colón |first4=Caterina I. |last5=Li |first5=Rui |last6=Wong |first6=Ivy Tsz-Lo |last7=Coruh |first7=Ceyda |last8=Dharanipragada |first8=Prashanthi |last9=Lomeli |first9=Shirley H. |last10=Weiser |first10=Natasha E. |last11=Moriceau |first11=Gatien |last12=Zhang |first12=Xiao |last13=Bailey |first13=Chris |last14=Houlahan |first14=Kathleen E. |last15=Yang |first15=Wenting |date=November 2022 |title=Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH |journal=Nature Genetics |language=en |volume=54 |issue=11 |pages=1746–1754 |doi=10.1038/s41588-022-01190-0 |pmid=36253572 |pmc=9649439 |issn=1546-1718}}{{Cite journal |last1=Luebeck |first1=Jens |last2=Ng |first2=Alvin Wei Tian |last3=Galipeau |first3=Patricia C. |last4=Li |first4=Xiaohong |last5=Sanchez |first5=Carissa A. |last6=Katz-Summercorn |first6=Annalise C. |last7=Kim |first7=Hoon |last8=Jammula |first8=Sriganesh |last9=He |first9=Yudou |last10=Lippman |first10=Scott M. |last11=Verhaak |first11=Roel G. W. |last12=Maley |first12=Carlo C. |last13=Alexandrov |first13=Ludmil B. |last14=Reid |first14=Brian J. |last15=Fitzgerald |first15=Rebecca C. |date=April 2023 |title=Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus |journal=Nature |language=en |volume=616 |issue=7958 |pages=798–805 |doi=10.1038/s41586-023-05937-5 |pmid=37046089 |issn=1476-4687|pmc=10132967 |bibcode=2023Natur.616..798L }}{{Cite journal |last1=Tang |first1=Jun |last2=Weiser |first2=Natasha E. |last3=Wang |first3=Guiping |last4=Chowdhry |first4=Sudhir |last5=Curtis |first5=Ellis J. |last6=Zhao |first6=Yanding |last7=Wong |first7=Ivy Tsz-Lo |last8=Marinov |first8=Georgi K. |last9=Li |first9=Rui |last10=Hanoian |first10=Philip |last11=Tse |first11=Edison |last12=Mojica |first12=Salvador Garcia |last13=Hansen |first13=Ryan |last14=Plum |first14=Joshua |last15=Steffy |first15=Auzon |date=November 2024 |title=Enhancing transcription–replication conflict targets ecDNA-positive cancers |journal=Nature |language=en |volume=635 |issue=8037 |pages=210–218 |doi=10.1038/s41586-024-07802-5 |pmid=39506153 |issn=1476-4687|pmc=11540844 |bibcode=2024Natur.635..210T }}{{Cite journal |last1=Bailey |first1=Chris |last2=Pich |first2=Oriol |last3=Thol |first3=Kerstin |last4=Watkins |first4=Thomas B. K. |last5=Luebeck |first5=Jens |last6=Rowan |first6=Andrew |last7=Stavrou |first7=Georgia |last8=Weiser |first8=Natasha E. |last9=Dameracharla |first9=Bhargavi |last10=Bentham |first10=Robert |last11=Lu |first11=Wei-Ting |last12=Kittel |first12=Jeanette |last13=Yang |first13=S. Y. Cindy |last14=Howitt |first14=Brooke E. |last15=Sharma |first15=Natasha |date=November 2024 |title=Origins and impact of extrachromosomal DNA |journal=Nature |language=en |volume=635 |issue=8037 |pages=193–200 |doi=10.1038/s41586-024-08107-3 |pmid=39506150 |issn=1476-4687|pmc=11540846 |bibcode=2024Natur.635..193B }}{{Cite journal |last1=Hung |first1=King L. |last2=Jones |first2=Matthew G. |last3=Wong |first3=Ivy Tsz-Lo |last4=Curtis |first4=Ellis J. |last5=Lange |first5=Joshua T. |last6=He |first6=Britney Jiayu |last7=Luebeck |first7=Jens |last8=Schmargon |first8=Rachel |last9=Scanu |first9=Elisa |last10=Brückner |first10=Lotte |last11=Yan |first11=Xiaowei |last12=Li |first12=Rui |last13=Gnanasekar |first13=Aditi |last14=Chamorro González |first14=Rocío |last15=Belk |first15=Julia A. |date=November 2024 |title=Coordinated inheritance of extrachromosomal DNAs in cancer cells |journal=Nature |language=en |volume=635 |issue=8037 |pages=201–209 |doi=10.1038/s41586-024-07861-8 |pmid=39506152 |issn=1476-4687|pmc=11541006 |bibcode=2024Natur.635..201H }}

Mischel is a member of the National Academy of Medicine{{Cite web |date=2021-10-20 |title=Six professors elected to the National Academy of Medicine |url=https://med.stanford.edu/news/all-news/2022/10/professors-national-academy-medicine.html |access-date=2024-11-22 |website=News Center |language=en-US}} and recipient of the Ernst W. Bertner Memorial Award from MD Anderson for Distinguished Contributions to Cancer Research. Mischel is also an elected Fellow and Past-President of the American Society for Clinical Investigation, and an elected Fellow of the American Association of Physicians and The American Association for the Advancement of Science.

Mischel is married to [https://profiles.stanford.edu/deborah-kado Professor Deborah Kado], Chief of Geriatrics Research, co-director of the Stanford Longevity Center, and Director of the Palo Alto VA Geriatrics Research, Education, and Clinical Center. They have two daughters, [https://medicine.stanford.edu/residency/residency-overview/current-residents.html Dr. Anna Mischel] and [https://home.dartmouth.edu/news/2023-valedictorians-and-salutatorians Dr. Sarah Mischel].  Paul is the son of the cognitive philosopher Theodore Mischel and the nephew of the famed psychologist, Walter Mischel.

{{reflist}}

[https://www.cancergrandchallenges.org/news/team-edynamic-following-the-science-and-accelerating-our-understanding-of-ecdna Team eDyNAmiC: Following the science and accelerating our understanding of ecDNA]

[https://med.stanford.edu/news/all-news/2024/11/ecdna-cancer.html Cracking the code of DNA circles in cancer, Stanford Medicine-led team uncovers potential therapy]

[https://www.theguardian.com/society/2024/nov/06/zapping-rogue-dna-key-treating-aggressive-cancers-study Study raises hopes of treating aggressive cancers by zapping rogue DNA]

[https://momentum.stanford.edu/stories/cartographer-of-cancer The cartographer of cancer]

[https://scopeblog.stanford.edu/2022/08/15/coming-full-circle-with-extrachromosomal-dna-cancer-and-ptolemy/ Coming full circle with extrachromosomal DNA, cancer and Ptolemy]

[https://www.pnas.org/post/journal-club/some-cancers-cheat-during-mitosis-pass-their-most-dangerous-malignant-genes-into-growing-tumor Cancers cheat during mitosis to pass on their most malignant genes]{{DEFAULTSORT:Mischel, Paul}}

Category:1962 births

Category:Living people

Category:University of Pennsylvania alumni

Category:American cancer researchers

Category:Fellows of the American Association for the Advancement of Science

Category:Weill Cornell Medical College alumni

Category:University of California, Los Angeles faculty

Category:University of California, San Diego faculty

Category:Members of the National Academy of Medicine