Paul Schedl

{{Infobox scientist

| honorific_prefix =

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| birth_name =

| birth_date = {{birth date and age |1947|11|7}}

| birth_place = Iowa City, Iowa

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| fields = Molecular biology, genetics

| workplaces = University of Basel, Switzerland (Helen Hay Whitney fellow); Princeton University

| education = Stanford University (PhD 1975)

| doctoral_advisor =

| academic_advisors = Walter Gehring

| known_for = Control of gene expression in developmental systems

| awards =

| father =Harold Schedl

| mother =Naomi Schedl

| relatives =Andrew Schedl, Timothy Schedl (brothers)

}}

Paul Daniel Schedl (born November 7, 1947, in Iowa City, Iowa) is a Professor of Molecular Biology at Princeton University.

Schedl has made significant contributions to the field of the control of gene expression in developmental systems using the model system Drosophila melanogaster. On the genomic level, his lab has uncovered the mechanisms of chromatin regulation by the Polycomb and trithorax group genes.{{cite journal | doi= 10.1007/s00018-021-03776-z

|title = GAGA factor: a multifunctional pioneering chromatin protein

|journal = Cell. Mol. Life Sci.

|year = 2021

|volume =78|number=9|pages =4125–4141

|last1 = Chetverina| first1= Darya

|last2 = Erokhin|first2 = Maksim

|last3 = Schedl|first3 = Paul

|pmid = 33528710

|pmc = 8815297

}} At the transcriptional and post-transcriptional level, he made discoveries in the regulation of alternative splicing of the sex determination gene, Sxl.{{cite journal | doi= 10.1128/MCB.16.9.5036

| title = Sex-lethal Interacts with Splicing Factors In Vitro and In Vivo

|first1 = Girish | last1= Deshpande

|first2 = Mark E.|last2 =Samuel

|first3 = Paul D. |last3 =Schedl

|pages = 5036–5047

| journal = Molecular and Cellular Biology

| volume = 16

|number =9

|year = 1996

| pmid = 8756662

|pmc = 231505

}}{{cite magazine |last=Merritt |first=J.I. |date=September 30, 1987 |title=Fruit Flies |url=https://books.google.com/books?id=TBJbAAAAYAAJ |magazine=Princeton Alumni Weekly |volume=88 |publisher=Princeton University Press |page=19 |access-date=July 30, 2021}}{{cite magazine |last=Patrusky |first=Ben |date=Fall 1992 |title=The Intron Story |url=https://books.google.com/books?id=3Y__M9X6jdMC |magazine=Mosaic |volume=23 |issue=3 |page=33 |publisher=The Foundation |access-date=July 30, 2021}} At the level of translational control, he discovered the function of the orb and orb2 gene in early development.{{cite journal | doi= 10.1242/dev.198788

|year = 2021

|volume = 148|number = 17

|title = The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis

|journal = Development

|first1 = Rudolf |last1 =Gilmutdinov

|first2 = Eugene N.|last2 =Kozlov

|first3 = Konstantin V. |last3 =Yakovlev

|first4 = Ludmila V. |last4 =Olenina

|first5 = Alexei A.|last5 = Kotov 3

|first6 = Justinn|last6 =Barr

|first7 = Mariya|last7 = Zhukova

|first8 = Paul|last8 = Schedl

|first9 = Yulii V.|last9 = Shidlovskii

|pages = dev198788

|pmid = 34473243

|pmc = 8513165

}}

Schedl obtained his PhD in 1975 at Stanford University, and was a Helen Hay Whitney postdoctoral fellow in Walter Gehring's lab at the University of Basel, Switzerland.{{cite journal | doi=10.1016/0092-8674(78)90346-X

|journal = Cell

|volume = 14| number = 4|year=1978|pages = 921–929

|title = Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein

|first1 = Paul|last1 = Schedl

|first2 = Spyridon|last2 =Artavanis-Tsakonas

|first3 = Ruth|last3 = Steward

|first4 = Walter J.|last4 = Gehring

|first5 = Marc-Edouard |last5 = Mirault

|first6 = Michel |last6 =Goldschmidt-Clermont

|first7 = Larry|last7 = Moran

| first8 =Alfred|last8 = Tissières

|pmid = 99246

}} Schedl has been a member of the faculty at Princeton University since 1978.

As of 2006, Schedl has published 132 papers, mentored 28 graduate students, sponsored 25 postdoctoral fellows and collaborated with 79 scientists.

Schedl was born to Harold Schedl, a professor of chemistry at the University of Iowa, and Naomi Schedl, a professor of art. He has two brothers, Andrew Schedl and Timothy Schedl.