Paul Sigler

{{Infobox person

| name = Paul B. Sigler

| image =

| caption =

| birth_date = {{Birth date|1934|02|19}}{{cite web|url=http://www.iucr.org/people/crystallographers/sigler|title=(IUCr) Paul B. Sigler (1934-2000)|publisher=}}

| birth_place = Richmond, Virginia, US

| death_date = {{Death date and age|2000|01|11|1934|02|19}}

| death_place = New Haven, Connecticut, US

| monuments = {{ubl|Memorial plaque on Science Hill (Yale University)|[https://lsi.princeton.edu/ Lewis-Sigler Institute for Integrative Genomics] at Princeton University}}

| nationality = American

| occupation = Professor

| children = 5 children

| module = {{Infobox scientist|embed = yes

| notable_works =

| known_for = Phospholipase A2
trp repressor

| thesis_title =

| thesis_year =

| doctoral_advisors = David M. Blow{{cite web|url=http://academictree.org/chemistry/peopleinfo.php?pid=52370|title=Blow on AcademicTree.org}}

| academic_advisors =

| workplaces = Yale University
University of Chicago
MRC-LMB
NIH

| field = Biophysics
Biochemistry

| alma_mater = Princeton University
Columbia University (MD)
Cambridge University (PhD)

| website = {{URL|1=http://www.hhmi.org/scientists/paul-b-sigler}}

| awards = National Academy of Sciences
HHMI Investigator{{cite web|url=http://www.hhmi.org/scientists/paul-b-sigler|title=Paul B. Sigler, MD, PhD - HHMI.org|work=HHMI.org}}
Guggenheim Fellow
Helen Hay Whitney Fellow{{cite web|url=http://www2.mrc-lmb.cam.ac.uk/about-lmb/archive-and-alumni/alumni/paul-sigler-1934-2000/|title=Paul Sigler (1934-2000) MRC Laboratory of Molecular Biology}}

}}

| spouse = Althea Jo Martin Sigler

}}

Paul B. Sigler ({{Birth date|1934|02|19}} – {{Death date|2000|01|11}}[http://www.nasonline.org/member-directory/deceased-members/43385.html National Academy of Sciences]) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University.{{cite web|url=http://news.yale.edu/1998/10/23/biochemist-paul-b-sigler-named-endowed-chair-yale|title=Yale University Press Release|date=23 October 1998 }}{{cite web|url=http://www.hhmi.org/scientists/paul-b-sigler|title=Official Site}} Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim and Helen Hay Whitney Fellowships. He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others.

Biography

Prior to coming to Yale, he was a professor at the University of Chicago. He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955. After briefly practicing medicine and working as a researcher for the NIH, he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology{{cite news|url=https://www.nytimes.com/2000/01/15/us/dr-paul-b-sigler-65-scientist-who-studied-organic-structure.html|title=New York Times Obit|work=The New York Times |date=15 January 2000 |last1=Saxon |first1=Wolfgang }} working under David M. Blow before moving to the University of Chicago.

Memorials

A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry.{{citation|url=http://secretary.yale.edu/services-resources/lectureships-fellowships-and-prizes/department-prizes?field_department_or_subject_tid%5B%5D=41|title=Paul Sigler Memorial}} Yale also has sponsored Paul Sigler memorial symposia in the past.{{cite web|url=http://www.rc.yale.edu/PBSSymposium/index.html|title=Paul Sigler Symposium|publisher=}} The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.{{cite web|url=http://www.hhwf.org/HTMLSrc/Corporate.html|title=Helen Hay Whitney Foundation - Announcement|publisher=}}

Death

Paul Sigler died on January 11, 2000, at New Haven, Connecticut, US, about a month before his 66th birthday.{{cn|date=May 2023}}

Selected publications

{{cite journal|doi=10.1038/379311a0|pmid=8552184|title=The 2.0 Å crystal structure of a heterotrimeric G protein|journal=Nature|volume=379|issue=6563|pages=311–9|year=1996|last1=Lambright|first1=David G.|last2=Sondek|first2=John|last3=Bohm|first3=Andrew|last4=Skiba|first4=Nikolai P.|last5=Hamm|first5=Heidi E.|last6=Sigler|first6=Paul B.|author5-link=Heidi Hamm|bibcode=1996Natur.379..311L|s2cid=4350943}}
{{cite journal|doi=10.1038/352497a0|pmid=1865905|title=Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA|journal=Nature|volume=352|issue=6335|pages=497–505|year=1991|last1=Luisi|first1=B. F.|last2=Xu|first2=W. X.|last3=Otwinowski|first3=Z.|last4=Freedman|first4=L. P.|last5=Yamamoto|first5=K. R.|last6=Sigler|first6=P. B.|bibcode=1991Natur.352..497L|s2cid=1919276}}
{{cite journal|doi=10.1038/371578a0|pmid=7935790|title=The crystal structure of the bacterial chaperonln GroEL at 2.8 Å|journal=Nature|volume=371|issue=6498|pages=578–86|year=1994|last1=Braig|first1=Kerstin|last2=Otwinowski|first2=Zbyszek|last3=Hegde|first3=Rashmi|last4=Boisvert|first4=David C.|last5=Joachimiak|first5=Andrzej|last6=Horwich|first6=Arthur L.|last7=Sigler|first7=Paul B.|bibcode=1994Natur.371..578B|s2cid=4341993}}
{{cite journal|doi=10.1038/365512a0|pmid=8413604|title=Crystal structure of a yeast TBP/TATA-box complex|journal=Nature|volume=365|issue=6446|pages=512–20|year=1993|last1=Kim|first1=Youngchang|last2=Geiger|first2=James. H.|last3=Hahn|first3=Steven|last4=Sigler|first4=Paul B.|bibcode=1993Natur.365..512K|s2cid=4336203}}
{{cite journal|doi=10.1126/science.2683088|pmid=2683088|title=Scissors-grip model for DNA recognition by a family of leucine zipper proteins|journal=Science|volume=246|issue=4932|pages=911–6|year=1989|last1=Vinson|first1=C.|last2=Sigler|first2=P.|last3=McKnight|first3=S.|bibcode=1989Sci...246..911V}}
{{cite journal|pmid=3419502|year=1988|last1=Otwinowski|first1=Z|title=Crystal structure of trp repressor/operator complex at atomic resolution|journal=Nature|volume=335|issue=6188|pages=321–9|last2=Schevitz|first2=R. W.|last3=Zhang|first3=R. G.|last4=Lawson|first4=C. L.|last5=Joachimiak|first5=A|last6=Marmorstein|first6=R. Q.|last7=Luisi|first7=B. F.|last8=Sigler|first8=P. B.|doi=10.1038/335321a0|bibcode=1988Natur.335..321O|s2cid=9358980}}

References

External links

{{Official website|1=http://www.hhmi.org/scientists/paul-b-sigler|name = Official website at HHMI}}
[http://academictree.org/chemistry/tree.php?pid=62128 Paul B. Sigler on AcademicTree]

Category:Princeton University alumni

Category:American biophysicists

Category:20th-century American biochemists

Category:Yale University faculty

Category:University of Chicago faculty

Category:Yale Department of Molecular Biophysics & Biochemistry faculty

Category:Scientists from New Haven, Connecticut

Category:Scientists from Chicago

Category:Scientists from New York City

Category:Scientists from Cambridge

Category:Scientists from Princeton, New Jersey

Category:Scientists from Washington, D.C.