Paul W. Ewald

Ewald received his BSc in 1975 from the University of California, Irvine, in biological sciences and his PhD in 1980 from the University of Washington, in zoology, with specialization in ecology and evolution. He was formerly a professor of biology at Amherst College, and is currently director of the program in evolutionary medicine in the Biology Department of the University of Louisville.[https://louisville.edu/biology/faculty/faculty-info Biology Department Faculty] University of Louisville

Ewald asserts, along with a growing body of studies, that many common diseases of unknown origin are likely the result of chronic low-level infections from viruses, bacteria or protozoa. For example, cervical cancer can be caused by the human papilloma virus, some cases of liver cancer are caused by hepatitis C or B and the bacteria Helicobacter pylori has been proven to cause stomach ulcers. Ewald argues that many common diseases of currently unknown etiology, such as cancers, heart attacks, stroke and Alzheimer's, may likewise be also caused by chronic low-level microbial infection.

Ewald disagrees with the popular theory that genes alone dictate chronic disease susceptibility. Ewald, whose background is in evolutionary biology, points out that any disease causing gene that reduces survival and reproduction would normally eliminate itself over a number of generations. Ewald says that "chronic diseases, if they are common and damaging, must be powerful eliminators of any genetic instruction that may cause them." One example of this is schizophrenia; patients with this mental illness rarely reproduce. Ewald argues that, just by evolutionary pressures, schizophrenia would have already been eliminated if its causes were strictly genetic; he suggests that in the future, an infectious cause of schizophrenia will be discovered.

Ewald explains that purely genetic causes of chronic disease will persist only if a genetic instruction provides a compensating benefit (for example, the disease sickle cell anemia is caused by a genetic mutation that, in heterozygotes, protects against malaria, which kills millions worldwide each year).

Further evidence for a non-genetic etiology of diseases like schizophrenia, Ewald also points out, comes from concordance studies on identical twins, which measure the percentage of identical twins who both develop a disease. A concordance of 100% indicates a primarily genetic disease, which is not really influenced by environmental factors like infection, nutrition, or toxins. Huntington's disease, for example, has a concordance rate of 100%, indicating a predominately genetic etiology. However, when the concordance rate is lower, this indicates environmental factors like infectious microbes or toxin exposure are playing a causal role. Schizophrenia's concordance is approximately 35-60%, suggesting, says Ewald, that microbes are etiologically involved. Another example is breast cancer: Ewald notes that in the case of identical twins, when one twin develops breast cancer, the other twin has only a 10% to 20% chance of developing the disease, and this concordance rate of just 20% again indicates that environmental factors like infectious microbes or toxins are likely playing large causal roles in breast cancer.

Ewald's curiosity regarding the evolutionary process of infections was sparked by a bad case of diarrhea he had in 1977. His first thought during this bout was that his body was using diarrhea to expel the pathogen and he should avoid anti-diarrheal medication. Looking at the problem from the standpoint of the organism, expulsion was not an evolutionary benefit. The only benefit to the pathogen causing the sickness would be the potential transmission to other hosts; much like the particulate expelled during coughing, diarrhea can be a means of distribution. Another major influence on Ewald's thinking in evolutionary biology terms was the HIV virus, which once caught, initially remains inactive for years thus allowing it to spread, before the chronic disease of AIDS finally manifests, incapacitates, and eventually kills the host.

In 2010, Utne Reader magazine named Ewald as one of the "25 Visionaries Who Are Changing Your World" for his research on the link between infections and cancers.

• "Like many great ideas in biology, the idea implicating infectious causation in chronic diseases, though simple, has far-reaching implications. It is so simple and so significant, that one would think it would have been recognized by many and would be the starting point for any discussion on the causes of disease. Not yet." — Paul W. Ewald.
• "If I were going to put my money on it, I would bet that by 2050—hopefully earlier—we’ll have found that more than 80 percent of all human cancer is caused by infection." — Paul W. Ewald.
• Of Ewald's theory: "It opens our eyes to many quite weird possibilities about disease that most medical scientists, tending to be unaware of current evolutionary thought, don't think of." — evolutionary biologist William D. Hamilton. {{citation needed|date=February 2011}}

• Evolution of Infectious Disease (1994){{Cite book|title=Evolution of Infectious Disease|last=Ewald.|first=Paul W.|date=1994|publisher=Oxford University Press|isbn=978-1423734697|location=Oxford|oclc=228117631}}
• [https://books.google.com/books?id=HlmxmE6TMCwC Plague Time: The New Germ Theory of Disease] (2002)Plague Time

• [https://www.ncbi.nlm.nih.gov/pubmed/24222188 "Transmission modes and the evolution of virulence"] (1991){{Cite journal|last=Ewald|first=P. W.|date=1991|title=Transmission modes and the evolution of virulence : With special reference to cholera, influenza, and AIDS|journal=Human Nature (Hawthorne, N.Y.)|volume=2|issue=1|pages=1–30|doi=10.1007/BF02692179|issn=1045-6767|pmid=24222188|s2cid=11765810}}
• "The Evolution of Virulence: A Unifying Link between Parasitology and Ecology" (1995){{Cite journal|last=Ewald|first=Paul W.|date=1995|title=The Evolution of Virulence: A Unifying Link between Parasitology and Ecology|journal=The Journal of Parasitology|volume=81|issue=5|pages=659–669|doi=10.2307/3283951|jstor=3283951|pmid=7472852}}
• [https://www.ncbi.nlm.nih.gov/pubmed/8969242/ "Guarding Against the MostDangerous Emerging Pathogens: Insights from Evolutionary Biology"] (1996){{Cite journal|last=Ewald|first=Paul|date=1996|title=Guarding Against the Most Dangerous Emerging Pathogens: Insights from Evolutionary Biology|journal=Emerging Infectious Diseases|language=en-us|volume=2|issue=4|pages=245–257|doi=10.3201/eid0204.960401|issn=1080-6040|pmc=2639916|pmid=8969242}}
• "Vaccines as evolutionary tools: The virulence-antigen strategy" (1996) in Concepts in Vaccine Development{{Cite book|title=Concepts in vaccine development|others=Kaufmann, S. H. E. (Stefan H. E.)|isbn=9783110906660|location=Berlin|chapter=Vaccines as evolutionary tools: The virulence-antigen strategy|oclc=859154818|last1=Kaufmann|first1=Stefan H. E|date=2012-05-24}}
• "Alternative Transmission Modes and the Evolution of Virulence" (2002) in Adaptive Dynamics of Infectious Diseases{{Citation|last1=Ewald|first1=Paul W.|title=Alternative Transmission Modes and the Evolution of Virulence|date=2002|work=Adaptive Dynamics of Infectious Diseases|pages=10–25|publisher=Cambridge University Press|language=en|doi=10.1017/cbo9780511525728.004|isbn=9780511525728|last2=Leo|first2=Giulio De}}
• "Virulence Management in Humans" (2002) in Adaptive Dynamics of Infectious Diseases{{Citation|last=Ewald|first=Paul W.|date=2002|chapter-url=https://www.cambridge.org/core/books/adaptive-dynamics-of-infectious-diseases/virulence-management-in-humans/B8AE1331C0D774757A917BA745AB6298|pages=399–412|publisher=Cambridge University Press|language=en|doi=10.1017/cbo9780511525728.036|isbn=9780511525728|access-date=2018-09-08|title=Adaptive Dynamics of Infectious Diseases|chapter=Virulence Management in Humans}}
• [https://www.ncbi.nlm.nih.gov/pubmed/?term=Ewald%20PW%5BAuthor%5D&cauthor=true&cauthor_uid=9762645 Other publications by Paul Ewald on PubMed].

• Human Microbiome Project
• Koch's postulates
• Medical microbiology

{{reflist|refs=

Plague Time, p.3

Plague Time, p.6

Plague Time, p.56

Plague Time, p.156

{{cite web | title = Paul Ewald: Virally Minded | url = http://www.utne.com/Politics/Utne-Reader-Visionaries-Paul-Ewald-Biologist-Cancer.aspx | access-date = 19 October 2010}}

{{cite journal | title = A New Germ Theory: Part 1 | journal = The Atlantic Monthly | date = Feb 1999 | first = Judith | last = Hooper | url = https://www.theatlantic.com/past/docs/issues/99feb/germs.htm}}

{{cite journal | title = A New Germ Theory: Part 2: Antibiotics Against Heart Disease? | journal = The Atlantic Monthly | date = Feb 1999 | first = Judith | last = Hooper | url = https://www.theatlantic.com/past/docs/issues/99feb/germ2.htm}}

{{cite journal | doi = 10.1186/1477-7819-3-27 | year = 2005 | last1 = Michielsen | first1 = Peter P | last2 = Francque | first2 = Sven M | last3 = Van Dongen | first3 = Jurgen L | journal = World Journal of Surgical Oncology | volume = 3 | pages = 27 | pmid = 15907199 | title = Viral hepatitis and hepatocellular carcinoma | pmc = 1166580 | doi-access = free }}

{{cite journal | pmid = 11919208 | year = 2002 | last1 = Bosch | first1 = FX | last2 = Lorincz | first2 = A | last3 = Muñoz | first3 = N | last4 = Meijer | first4 = CJ | last5 = Shah | first5 = KV | title = The causal relation between human papillomavirus and cervical cancer | volume = 55 | issue = 4 | pages = 244–65 | pmc = 1769629 | journal = Journal of Clinical Pathology | doi = 10.1136/jcp.55.4.244}}

{{cite journal | author = Hadley C | title = The infection connection. Helicobacter pylori is more than just the cause of gastric ulcers--it offers an unprecedented opportunity to study changes in human microecology and the nature of chronic disease | journal = EMBO Rep | volume = 7 | issue = 5 | pages = 470–3 | year = 2006 | pmid = 16670677 | doi = 10.1038/sj.embor.7400699 | pmc = 1479565 }}

{{cite journal | title = The Big Idea That Might Beat Cancer and Cut Health-Care Costs by 80 Percent | journal = Discover Magazine | date = Sep 2009 | first = Andrew | last = Grant | url = http://discovermagazine.com/2009/new-science-of-health/big-idea-beat-cancer-cut-health-care-costs-80-percent}}

{{cite journal | title = Interview With Evolutionary Biologist Paul Ewald | journal = Discover Magazine | date = Feb 2008 | first = Amy | last = Proal | url = http://bacteriality.com/2008/02/11/ewald/}}

}}

• [https://www.youtube.com/watch?v=5q9zAG92V9M Toward a unified, evolutionary theory of cancer], presentation by Paul Ewald 2016
• [http://microbeminded.com/2017/11/11/interview-with-evolutionary-biologist-paul-ewald-infection-and-chronic-disease/ Interview With Evolutionary Biologist Paul Ewald], by Amy Proal
• [https://www.discovermagazine.com/health/the-big-idea-that-might-beat-cancer-and-cut-health-care-costs-by-80-percent The Big Idea That Might Beat Cancer and Cut Health-Care Costs by 80 Percent] by Andrew Grant, Discover Magazine, Sept 2009
• [https://www.theatlantic.com/past/docs/issues/99feb/germs.htm A New Germ Theory: Part 1] by Judith Hooper, The Atlantic Monthly, Feb 1999
• [https://www.theatlantic.com/past/docs/issues/99feb/germ2.htm A New Germ Theory: Part 2: Antibiotics Against Heart Disease?]
• [https://www.theatlantic.com/past/docs/issues/99feb/germ3.htm A New Germ Theory: Part 3: The Great Synthesizer]
• [https://www.ted.com/talks/paul_ewald_can_we_domesticate_germs Can we domesticate germs? (TED2007)]
• [https://www.psychologytoday.com/gb/articles/199907/the-infection-connection The Infection Connection] by Harriet Washington, Psychology Today
• [https://sites.google.com/site/humandiseaseslinkedtopathogens/ List of Human Diseases Linked to Infectious Pathogens]

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Category:1950s births

Category:Living people

Category:American evolutionary biologists

Category:University of Washington College of Arts and Sciences alumni

Category:University of California, Irvine alumni

Category:University of Louisville alumni

Category:Year of birth missing (living people)