Peter M. Howley

Howley was born in New Brunswick, New Jersey. He graduated in 1968 from Princeton University with an A.B. in chemistry and in 1970 from Rutgers University with an M.M.S. (Master of Medical Science) degree. In 1972 he graduated with an M.D. from Harvard Medical School. From 1972 to 1973 he worked as an intern in pathology at Massachusetts General Hospital. He was a research associate from 1973 to 1975 at the National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, Maryland. In 1977 he was granted board certification in anatomic pathology.

At the NCI's Laboratory of Pathology, Howley was from 1975 to 1976 a resident, from 1976 to 1977 a junior staff pathologist, from 1977 to 1979 a senior investigator, and from 1979 to 1984 Chief of the Viral Oncology and Molecular Pathology Section. From 1984 to 1993 he was Chief of the NCI's Laboratory of Tumor Virus Biology.

In 1991, Howley became the George Fabyan Professor of Comparative Pathology at Harvard Medical School.{{cite book |title=Harvard University History of Named Chairs: Sketches of Donors and Donations 1991 – 2004 |date=2005 |publisher=Harvard University |location=Cambridge, Massachusetts |pages=100–103 |url=https://alumni.neurosurgery.mgh.harvard.edu/docs/Harvard_Professorsips_Book_1721-1992.pdf}}

He was the president of the American Society for Virology from 1998 to 1999{{cite web |title=Presidents of The American Society for Virology |url=https://asv.org/past-presidents/ |website=American Society for Virology |access-date=4 October 2021}} and the president of the American Society for Investigative Pathology in 2006.{{cite web |title=Past Officers of ASIP (Formerly the American Association of Pathologists) |url=https://www.asip.org/about-asip/leadership/past-officers/ |website=American Society for Investigative Pathology (ASIP) |access-date=4 October 2021}}

By 2009 he was the Shattuck Professor of Pathology.{{cite web |title=The 2009 Harvard / Paul F. Glenn Symposium on Aging June 8, 2009 |url=https://www.hms.harvard.edu/agingresearch/2009program_web.pdf |website=Paul F. Glenn Laboratories at Harvard Medical School}}

Howley is considered to be a leader in research on papillomaviruses. Howley and his co-workers created gene maps of many species of papillomaviruses and analyzed their transcription patterns and systems of transcription regulation. The research identified papillomavirus oncogenes and the molecular mechanisms of their damaging effects. This work is considered fundamental for the understanding of the pathogenesis of papillomaviruses at the molecular level.{{cite web|title=Peter M Howley, MD|website=The Vallee Foundation|url=https://www.thevalleefoundation.org/programs/vvp/peter-m-howley-md}}

{{blockquote|His research also involves assessing the roles of the E6AP/UBE3A ubiquitin ligase in human neurogenetic disorders.}}

Peter M. Howley and David M. Knipe have been co-editors-in-chief, since the 3rd edition, of Fields Virology, a standard work on virology, with 5th edition published in 2006 and 6th edition published in 2013. Howley is also one of the chief editors of The Molecular Basis of Cancer, published by Elsevier.{{cite book|editor1=Mendelsohn, John|editor2=Howley, Peter M.|editor3=Israel, Mark A.|editor4=Gray, Joe W.|editor5=Thompson, Craig B.|title=The Molecular Basis of Cancer: Expert Consult - Online|url=https://books.google.com/books?id=bfPORhG6DP8C|date=1 April 2008|publisher=Elsevier Health Sciences|isbn=978-1-4377-1099-1}}{{cite book|editor=Mendelsohn, J.|editor2=Howley, P. M.|editor3=Israel, M. A.|editor4=Gray, J. W.|editor5=Thompson, C. B.|year=2014|title=The Molecular Basis of Cancer E-Book|publisher=Elsevier Health Sciences|isbn=978-0-323-26196-8|url=https://books.google.com/books?id=9ZSoAgAAQBAJ}} He was a co-editor of the Annual Review of Pathology: Mechanisms of Disease from 2007–2015.{{cite journal|doi=10.1086/523214|title=Annual Review of Pathology: Mechanisms of Disease. Volume 2: 2007. Edited by Abul K Abbas, Stephen J Galli, and, Peter M Howley. Palo Alto (California): Annual Reviews. $55.00. Xii + 429 p; ill.; no index. {{text|ISBN:}} 978-0-8243-4302-6. 2007.|journal=The Quarterly Review of Biology|year=2007|volume=82|issue=3|page=311}} He is a member of the editorial board of the ''Proceedings of the National Academy of Sciences.

He is married with three children.

Peter M. Howley should not be confused with Paul M. Howley, who is a managing director of the vaccine biotechnology firm VAXMED Pty Ltd in Melbourne, Australia.{{cite journal|last1=Prow|first1=Natalie A.|last2=Liu|first2=Liang|last3=McCarthy|first3=Mary K.|last4=Walters|first4=Kevin|last5=Kalkeri|first5=Raj|last6=Geiger|first6=Jillian|last7=Koide|first7=Fusataka|last8=Cooper|first8=Tamara H.|last9=Eldi|first9=Preethi|last10=Nakayama|first10=Eri|last11=Diener|first11=Kerrilyn R.|last12=Howley|first12=Paul M.|last13=Hayball|first13=John D.|last14=Morrison|first14=Thomas E.|last15=Suhrbier|first15=Andreas|title=The vaccinia virus based Sementis Copenhagen Vector vaccine against Zika and chikungunya is immunogenic in non-human primates|journal=npj Vaccines|volume=5|issue=1|year=2020|page=44|issn=2059-0105|doi=10.1038/s41541-020-0191-8|pmid=32550013|pmc=7265471|doi-access=free}}

• 1983 — Warner-Lamber/Parke-David Award{{cite journal|pmc=1916352|year=1983|last1=Howley|first1=P. M.|title=The molecular biology of papillomavirus transformation. Warner-Lambert Parke-Davis Award Lecture|journal=The American Journal of Pathology|volume=113|issue=3|pages=414–421|pmid=6316792}} of the American Society for Experimental Pathology{{cite journal|pmc=1853043|year=1998|last1=Cotran|first1=R. S.|title=Forty Years of the Warner-Lambert/ Parke-Davis Award : A Remarkable Record|journal=The American Journal of Pathology|volume=153|issue=4|page=1014|doi=10.1016/S0002-9440(10)65644-1|pmid=9777931}}
• 1986 — Wallace P. Rowe Award of the National Institute of Allergy and Infectious Diseasesfor{{cite web|title=Wallace P. Rowe Award Plaque|website=Office of History, National Institutes of Health|url=https://onih.pastperfectonline.com/webobject/A02771CB-55DD-4164-B646-252286375572}}
• 1997 — Member, American Society for Clinical Investigation{{cite web |title=Peter M. Howley, MD |url=https://the-asci.org/controllers/asci/AsciProfileController.php?pid=159590 |website=American Society for Clinical Investigation}}
• 1993 — Member of the National Academy of Sciences{{cite web|title=Peter M. Howley|website=National Academy of Sciences (nasonline.org)|url=http://www.nasonline.org/member-directory/members/64202.html}}
• 1994 — Paul Ehrlich and Ludwig Darmstaedter Prize{{cite web|title=Goethe-Universität — Preisträger seit 1952 (prizewinners since 1952)|periodical=Uni-frankfurt.de|publisher=|url=http://www.uni-frankfurt.de/44556747/preistraeger|url-status=|format=|archive-url=|archive-date=|last=|year=|language=de|pages=|quote=}} (also awarded to Harald zur Hausen)
• 1996 — Fellow of the American Academy of Arts & Sciences{{cite web|title=Book of Members 1780—present, Chapter H|website=American Academy of Arts and Sciences|url=https://www.amacad.org/sites/default/files/academy/multimedia/pdfs/publications/bookofmembers/ChapterH.pdf}}
• 2004 — Rous-Whipple Award of the American Society for Investigative Pathology{{cite web |title=ASIP Rous-Whipple Award |url=https://www.asip.org/membership-community/awards-honors/meritorious-awards/asip-rous-whipple-award/ |website=American Society for Investigative Pathology |language=en}}
• 2011 — Keynote speaker at the Convocation Ceremony of the Robert Wood Johnson Medical School{{cite web|title=Event Release - May 2011, News Publications|website=Robert Wood Johnson Medical School, Rutgers University|url=http://rwjms.rutgers.edu/news_publications/news_release/2010_release/Convocation_2011.html}}
• 2015 — NCI Outstanding Investigator Award, National Cancer Institute{{cite web |title=2015 Recipients of NCI Outstanding Investigator Awards - NCI |url=https://www.cancer.gov/grants-training/grants-funding/funding-opportunities/oia/award-recipients/2015 |website=National Cancer Institute |access-date=14 June 2023 |language=en |date=14 October 2015}}

• {{cite journal|doi=10.1038/287072a0|title=In vitro tumorigenic transformation by a defined sub-genomic fragment of bovine papilloma virus DNA|year=1980|last1=Lowy|first1=Douglas R.|last2=Dvoretzky|first2=Israel|last3=Shober|first3=Ralph|last4=Law|first4=Ming-Fan|last5=Engel|first5=Linda|last6=Howley|first6=Peter M.|journal=Nature|volume=287|issue=5777|pages=72–74|pmid=6251381|bibcode=1980Natur.287...72L|s2cid=4278780}} 1980
• {{cite journal|doi=10.1073/pnas.78.5.2727|title=Mouse cells transformed by bovine papillomavirus contain only extrachromosomal viral DNA sequences|year=1981|last1=Law|first1=M. F.|last2=Lowy|first2=D. R.|last3=Dvoretzky|first3=I.|last4=Howley|first4=P. M.|journal=Proceedings of the National Academy of Sciences|volume=78|issue=5|pages=2727–2731|pmid=6265905|pmc=319430|bibcode=1981PNAS...78.2727L|doi-access=free}} 1981
• {{cite journal|doi=10.1038/299529a0|title=The primary structure and genetic organization of the bovine papillomavirus type 1 genome|year=1982|last1=Chen|first1=Ellson Y.|last2=Howley|first2=Peter M.|last3=Levinson|first3=Arthur D.|last4=Seeburg|first4=Peter H.|journal=Nature|volume=299|issue=5883|pages=529–534|pmid=6289124|bibcode=1982Natur.299..529C|s2cid=4330135|doi-access=free}} 1982
• {{cite journal|doi=10.1073/pnas.82.4.1030|title=Bovine papillomavirus contains multiple transforming genes|year=1985|last1=Yang|first1=Y. C.|last2=Okayama|first2=H.|last3=Howley|first3=P. M.|journal=Proceedings of the National Academy of Sciences|volume=82|issue=4|pages=1030–1034|pmid=2983327|pmc=397187|bibcode=1985PNAS...82.1030Y|doi-access=free}} 1985
• {{cite journal|doi=10.1073/pnas.83.24.9759|title=Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses|year=1986|author1-link=Howard E. Gendelman|last1=Gendelman|first1=H. E.|last2=Phelps|first2=W.|last3=Feigenbaum|first3=L.|last4=Ostrove|first4=J. M.|last5=Adachi|first5=A.|last6=Howley|first6=P. M.|last7=Khoury|first7=G.|last8=Ginsberg|first8=H. S.|last9=Martin|first9=M. A.|journal=Proceedings of the National Academy of Sciences|volume=83|issue=24|pages=9759–9763|pmid=2432602|pmc=387220|bibcode=1986PNAS...83.9759G|doi-access=free}} 1986
• {{cite journal|doi=10.1126/science.2537532|title=The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product|year=1989|last1=Dyson|first1=N.|last2=Howley|first2=P.|last3=Munger|first3=K.|last4=Harlow|first4=E.|journal=Science|volume=243|issue=4893|pages=934–937|pmid=2537532|bibcode=1989Sci...243..934D}} 1989
• {{cite journal|doi=10.1126/science.2157286|title=Association of human papillomavirus types 16 and 18 E6 proteins with p53|year=1990|last1=Werness|first1=B.|last2=Levine|first2=A.|last3=Howley|first3=P.|journal=Science|volume=248|issue=4951|pages=76–79|pmid=2157286|bibcode=1990Sci...248...76W}} 1990
• {{cite journal|doi=10.1002/j.1460-2075.1991.tb04990.x|title=A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18|year=1991|last1=Huibregtse|first1=J.M.|last2=Scheffner|first2=M.|last3=Howley|first3=P.M.|journal=The EMBO Journal|volume=10|issue=13|pages=4129–4135|pmid=1661671|pmc=453163}} 1991
• {{cite journal|doi=10.1073/pnas.88.13.5523|title=The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines|year=1991|last1=Scheffner|first1=M.|last2=Munger|first2=K.|last3=Byrne|first3=J. C.|last4=Howley|first4=P. M.|journal=Proceedings of the National Academy of Sciences|volume=88|issue=13|pages=5523–5527|pmid=1648218|pmc=51909|bibcode=1991PNAS...88.5523S|doi-access=free}} 1991
• {{cite journal|doi=10.1073/pnas.89.10.4549|title=Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product|year=1992|last1=Chellappan|first1=S.|last2=Kraus|first2=V. B.|last3=Kroger|first3=B.|last4=Munger|first4=K.|last5=Howley|first5=P. M.|last6=Phelps|first6=W. C.|last7=Nevins|first7=J. R.|journal=Proceedings of the National Academy of Sciences|volume=89|issue=10|pages=4549–4553|pmid=1316611|pmc=49120|bibcode=1992PNAS...89.4549C|s2cid=23812634|doi-access=free}} 1992
• {{cite journal|doi=10.1073/pnas.92.7.2563|title=A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase|year=1995|last1=Huibregtse|first1=J. M.|last2=Scheffner|first2=M.|last3=Beaudenon|first3=S.|last4=Howley|first4=P. M.|journal=Proceedings of the National Academy of Sciences|volume=92|issue=7|pages=2563–2567|pmid=7708685|pmc=42258|bibcode=1995PNAS...92.2563H|doi-access=free}} 1995
• {{cite journal|doi=10.1073/pnas.94.9.4412|title=The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton|year=1997|last1=Tong|first1=X.|last2=Howley|first2=P. M.|journal=Proceedings of the National Academy of Sciences|volume=94|issue=9|pages=4412–4417|pmid=9114003|pmc=20736|bibcode=1997PNAS...94.4412T|doi-access=free}} 1997
• {{cite journal|last1=Wathelet|first1=Marc G|last2=Lin|first2=Charles H|last3=Parekh|first3=Bhavin S|last4=Ronco|first4=Lucienne V|last5=Howley|first5=Peter M|last6=Maniatis|first6=Tom|title=Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo|journal=Molecular Cell|volume=1|issue=4|year=1998|pages=507–518|issn=1097-2765|doi=10.1016/S1097-2765(00)80051-9|pmid=9660935|doi-access=free}}
• {{cite journal|doi=10.1126/science.286.5443.1321|title=Structure of an E6AP-UbcH7 Complex: Insights into Ubiquitination by the E2-E3 Enzyme Cascade|year=1999|last1=Huang|first1=L.|last2=Kinnucan|first2=E.|last3=Wang|first3=G.|last4=Beaudenon|first4=S.|last5=Howley|first5=P. M.|last6=Huibregtse|first6=J. M.|last7=Pavletich|first7=N. P.|journal=Science|volume=286|issue=5443|pages=1321–1326|pmid=10558980}} 1999
• {{cite journal|last1=Münger|first1=Karl|last2=Howley|first2=Peter M|title=Human papillomavirus immortalization and transformation functions|journal=Virus Research|volume=89|issue=2|year=2002|pages=213–228|issn=0168-1702|doi=10.1016/S0168-1702(02)00190-9|pmid=12445661}}
• {{cite journal|pmc=1500926|year=2006|last1=Howley|first1=P. M.|title=Warts, Cancer and Ubiquitylation: Lessons from the Papillomaviruses|journal=Transactions of the American Clinical and Climatological Association|volume=117|pages=113–127|pmid=18528468}}
• {{cite journal|last1=White|first1=E. A.|last2=Sowa|first2=M. E.|last3=Tan|first3=M. J. A.|last4=Jeudy|first4=S.|last5=Hayes|first5=S. D.|last6=Santha|first6=S.|last7=Münger|first7=K.|last8=Harper|first8=J. W.|last9=Howley|first9=P. M.|title=Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses|journal=Proceedings of the National Academy of Sciences|volume=109|issue=5|year=2012|pages=E260–E267|issn=0027-8424|doi=10.1073/pnas.1116776109|pmid=22232672|pmc=3277141|doi-access=free}}
• {{cite journal|last1=Howley|first1=Peter M.|last2=Pfister|first2=Herbert J.|title=Beta genus papillomaviruses and skin cancer|journal=Virology|volume=479-480|year=2015|pages=290–296|issn=0042-6822|doi=10.1016/j.virol.2015.02.004|pmid=25724416|pmc=4424140|doi-access=free}}

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Category:1946 births

Category:Living people

Category:People from New Brunswick, New Jersey

Category:American pathologists

Category:American virologists

Category:20th-century American physicians

Category:21st-century American physicians

Category:Fellows of the American Academy of Arts and Sciences

Category:Members of the United States National Academy of Sciences

Category:Princeton University alumni

Category:Rutgers University alumni

Category:Harvard Medical School alumni

Category:Harvard Medical School faculty

Category:Annual Reviews (publisher) editors