PhTx-2

This fraction is responsible for most of the venom's effects, acts on voltage-gated ion channels, this fraction is composed of nine different peptides, of which PhTx-2-5 and PhTx-2-6 activate voltage-gated ion channels.{{Cite book|last=Fernanber|url=https://books.google.com/books?id=BZMlWtbjav8C&q=PhTx2+3%2C5+mg&pg=PA341|title=TOXINOLOGIA CLINICA. LESIONES POR PICADURAS Y MORDEDURAS DE ANIMALES|date=2013-04-30|publisher=Bubok|isbn=978-84-686-3691-7|language=es}} PhTx-2 has been shown to be related to the activation and delay of inactivation of neuronal sodium channels, leading to an increase in the concentration of neuronal Ca++ and the release of glutamate, resulting in the release of neurotransmitters such as acetylcholine and catecholamines.{{Cite book|last1=Weiss|first1=Marcelo Barros|url=https://books.google.com/books?id=NzlyDwAAQBAJ&q=PhTx-2+convuls%C3%B5es+paralisias&pg=PT161|title=Acidentes com Animais Peçonhentos|last2=Paiva|first2=Jorge Wilson Souza|date=2018-10-10|publisher=Thieme Revinter Publicações LTDA|isbn=978-85-5465-084-1|language=pt-BR}} Primates are more sensitive to the PhTx-1 & 2 components than in the case of mice, about 4 to 5 times more sensitive. The LD50 for a 70kg adult human is 6.3 mg, but the spider has only 1-2 mg and usually delivers 0.4 mg.

Category:Toxicology