Pocapavir
{{Short description|Antiviral drug}}
{{infobox drug
| drug_name = Pocapavir
| image = Pocapavir_structure.png
| legal_UK =
| legal_DE =
| C = 21 | H = 17 | Cl = 3 | O = 3
| IUPAC_name =
| CAS_number = 146949-21-5
| ChEMBL = CHEMBL1235858
| DrugBank = DB17736
| ChemSpiderID =
| PubChem = 1455
| UNII = 4ILA3VOV97
| smiles = COC1=CC(=C(C=C1)OCC2=CC=C(C=C2)COC3=C(C=CC=C3Cl)Cl)Cl
| StdInChI= 1S/C21H17Cl3O3/c1-25-16-9-10-20(19(24)11-16)26-12-14-5-7-15(8-6-14)13-27-21-17(22)3-2-4-18(21)23/h2-11H,12-13H2,1H3
| StdInChIKey = XXMDDBVNWRWNCW-UHFFFAOYSA-N
| synonyms = V-073
}}
Pocapavir (V-073, SCH48973) is an antiviral drug which acts as a capsid inhibitor. It was developed for the treatment of enterovirus infections, including diseases such as polio and coxsackievirus, and also has activity against parechoviruses.{{cite journal | vauthors = Lentz KN, Smith AD, Geisler SC, Cox S, Buontempo P, Skelton A, DeMartino J, Rozhon E, Schwartz J, Girijavallabhan V, O'Connell J, Arnold E | title = Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes | journal = Structure | volume = 5 | issue = 7 | pages = 961–978 | date = July 1997 | pmid = 9261087 | doi = 10.1016/s0969-2126(97)00249-9 }}{{cite journal | vauthors = De Palma AM, Pürstinger G, Wimmer E, Patick AK, Andries K, Rombaut B, De Clercq E, Neyts J | title = Potential use of antiviral agents in polio eradication | journal = Emerging Infectious Diseases | volume = 14 | issue = 4 | pages = 545–551 | date = April 2008 | pmid = 18394270 | doi = 10.3201/eid1404.070439 | pmc = 2570929 }}{{cite journal | vauthors = McKinlay MA, Collett MS, Hincks JR, Oberste MS, Pallansch MA, Okayasu H, Sutter RW, Modlin JF, Dowdle WR | title = Progress in the development of poliovirus antiviral agents and their essential role in reducing risks that threaten eradication | journal = The Journal of Infectious Diseases | volume = 210 | pages = S447–S453 | date = November 2014 | pmid = 25316866 | doi = 10.1093/infdis/jiu043 }}{{cite journal | vauthors = Torres-Torres S, Myers AL, Klatte JM, Rhoden EE, Oberste MS, Collett MS, McCulloh RJ | title = First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis | journal = The Pediatric Infectious Disease Journal | volume = 34 | issue = 1 | pages = 52–54 | date = January 2015 | pmid = 25229269 | doi = 10.1097/INF.0000000000000497 }}{{cite journal | vauthors = Collett MS, Hincks JR, Benschop K, Duizer E, van der Avoort H, Rhoden E, Liu H, Oberste MS, McKinlay MA, Hartford M | title = Antiviral Activity of Pocapavir in a Randomized, Blinded, Placebo-Controlled Human Oral Poliovirus Vaccine Challenge Model | journal = The Journal of Infectious Diseases | volume = 215 | issue = 3 | pages = 335–343 | date = February 2017 | pmid = 27932608 | doi = 10.1093/infdis/jiw542 | pmc = 5393058 }}{{cite journal | vauthors = Harik N, DeBiasi RL | title = Neonatal nonpolio enterovirus and parechovirus infections | journal = Seminars in Perinatology | volume = 42 | issue = 3 | pages = 191–197 | date = April 2018 | pmid = 29526382 | doi = 10.1053/j.semperi.2018.02.007 }}{{cite journal | vauthors = Copelyn J, Hincks JR, Wilmshurst JM, Petersen W, Howard W, Jallow S, Moonsamy S, Seakamela L, Suchard M, Collett MS, Eley B | title = Clearance of Immunodeficiency-associated Vaccine-derived Poliovirus Infection With Pocapavir | journal = The Pediatric Infectious Disease Journal | volume = 39 | issue = 5 | pages = 435–437 | date = May 2020 | pmid = 32150007 | doi = 10.1097/INF.0000000000002584 }}{{cite journal | vauthors = Kankam MK, Burns JM, Collett MS, Corrado ML, Hincks JR | title = A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of V-7404 in Healthy Adult Volunteers | journal = Antimicrobial Agents and Chemotherapy | volume = 65 | issue = 10 | pages = e0102921 | date = September 2021 | pmid = 34370575 | doi = 10.1128/AAC.01029-21 | pmc = 8448163 }}{{cite journal | vauthors = Tomatis Souverbielle C, Erdem G, Sánchez PJ | title = Update on nonpolio enterovirus and parechovirus infections in neonates and young infants | journal = Current Opinion in Pediatrics | volume = 35 | issue = 3 | pages = 380–389 | date = June 2023 | pmid = 36876331 | doi = 10.1097/MOP.0000000000001236 }}