Podophyllum resin

{{Short description|Chemical compound}}

{{Use dmy dates|date=March 2024}}

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| tradename = Podocon-25, others

| Drugs.com = {{Drugs.com|monograph|podophyllum-resin}}

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| ATC_prefix = D06

| ATC_suffix = BB04

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| CAS_number = 9000-55-9

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| UNII = 16902YVY2B

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Podophyllum resin, also known as podophyllum or podophyllin, is a resin made from the roots of the American mandrake.{{cite book| vauthors = Briggs GG, Freeman RK, Yaffe SJ |title=Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk|date=2011|publisher=Lippincott Williams & Wilkins|isbn=9781608317080|page=1190|url=https://books.google.com/books?id=OIgTE4aynrMC&pg=PA1190|language=en|url-status=live|archive-url=https://web.archive.org/web/20161222152308/https://books.google.ca/books?id=OIgTE4aynrMC&pg=PA1190|archive-date=22 December 2016}} It is used as a medication to treat genital warts and plantar warts, including in people with HIV/AIDS.{{cite web|title=Podophyllum Resin|url=https://www.drugs.com/monograph/podophyllum-resin.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161222084607/https://www.drugs.com/monograph/podophyllum-resin.html|archive-date=22 December 2016}} It is not recommended in HPV infections without external warts. Application by a healthcare provider to the skin is recommended.

Common side effects include redness, itchiness, and pain at the site of use. Severe side effects may include vomiting, abdominal pain, confusion, bone marrow suppression, and diarrhea. It is not recommended for more than a small area at a time. Use during pregnancy is known to be dangerous to the baby. It works mostly via podophyllotoxin which stops cell division.

Podophyllin resin has been used to treat warts since at least 1820.{{cite book | vauthors = Lata H, Chandra S| title = Medicinal plant biotechnology | chapter = Biotechnological characterization of different populations of an endangered medicinal herb - Podophyllum hexandrum Royle | veditors = Arora R |date=2010|publisher=CABI|isbn=9781845936921|page=36| chapter-url = https://books.google.com/books?id=3sPwKo3b3cUC&pg=PA36 |language=en | doi = 10.1079/9781845936785.0036 }} It is on the World Health Organization's List of Essential Medicines.{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 21st list 2019 | year = 2019 | hdl = 10665/325771 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO | hdl-access=free }}{{cite book | vauthors = ((World Health Organization)) | title = World Health Organization model list of essential medicines: 22nd list (2021) | year = 2021 | hdl = 10665/345533 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2021.02 | hdl-access=free }} A formulation known as podophyllotoxin with less side effects is also available.{{cite book | title = WHO Model Formulary 2008 | year = 2009 | isbn = 9789241547659 | vauthors = ((World Health Organization)) | veditors = Stuart MC, Kouimtzi M, Hill SR | hdl = 10665/44053 | author-link = World Health Organization | publisher = World Health Organization | pages = 307, 309 }}