Poly(a) binding protein interacting protein 2b

{{Short description|Protein-coding gene in the species Homo sapiens}}

Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene.

{{cite web

| title = Entrez Gene: Poly(A) binding protein interacting protein 2B

| url = https://www.ncbi.nlm.nih.gov/gene/400961

| accessdate = 2018-05-10

}}

Function

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008].

Poly(a) binding protein interacting protein 2b

Function

References

Further reading