Polyostotic fibrous dysplasia

{{short description|Replacement of more than one bone with fibrous tissue}}

{{Infobox medical condition (new)

| name = Polyostotic fibrous dysplasia

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| field = Osteology

| synonyms = Albright's diseaseJames, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. {{ISBN|0-7216-2921-0}}.{{rp|578}}

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Polyostotic fibrous dysplasia is a form of fibrous dysplasia affecting more than one bone.{{cite web |url=http://emedicine.medscape.com/article/389714-overview |title=Fibrous Dysplasia: Overview - eMedicine Radiology |access-date=2009-02-23}} Fibrous dysplasia is a disorder where bone is replaced by fibrous tissue, leading to weak bones, uneven growth, and deformity. {{Cite web|url=https://ghr.nlm.nih.gov/condition/mccune-albright-syndrome|title=McCune–Albright syndrome|last=Reference|first=Genetics Home|website=Genetics Home Reference|language=en|access-date=2018-10-30}}

McCune–Albright syndrome includes polyostotic fibrous dysplasia as part of its presentation.{{cite journal|last=Lee|first=Peter A.|title=McCune–Albright Syndrome: Long-term Follow-up|journal=JAMA: The Journal of the American Medical Association|date=5 December 1986|volume=256|issue=21|pages=2980–4|doi=10.1001/jama.1986.03380210076028|pmid=3773215}} When polyostotic fibrous dysplasia manifests in the long bones, limping results; when it manifests in the face, asymmetric growth of the face can result.

One treatment that has been used is bisphosphonates.{{cite journal |vauthors=Khadilkar VV, Khadilkar AV, Maskati GB |title=Oral bisphosphonates in polyostotic fibrous dysplasia |journal=Indian Pediatr |volume=40 |issue=9 |pages=894–6 |date=September 2003 |pmid=14530553 |url=http://www.indianpediatrics.net/sep2003/sep-894-896.htm}}