Polypoid melanoma
{{Short description|Rare virulent form of nodular melanoma}}
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| specialty = Dermatology/Oncology
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Polypoid melanoma is a rare cutaneous condition, a virulent variant of nodular melanoma.{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |year=2006 |isbn=978-0-7216-2921-6 |display-authors=etal}}{{rp|696}} Polypoid melanoma is a subtype of nodular melanoma, the most aggressive form of melanoma (a skin cancer).{{cite journal | last1=Maury | first1=Mikalah E | last2=Jukic | first2=Drazen M | title=A Case Presentation of Three Polypoid Melanomas With Divergent Features | journal=Cureus | publisher=Springer Science and Business Media LLC | date=October 13, 2023 | volume=15 | issue=10 | pages=e46951 | issn=2168-8184 | doi=10.7759/cureus.46951 | doi-access=free | pmid=38022238 | pmc=10640706 }}
Signs and symptoms
Polypoid melanoma is distinguished by a profile that resembles cauliflower and an uneven surface.{{cite journal | last1=Di Altobrando | first1=Ambra | last2=Patrizi | first2=Annalisa | last3=Dika | first3=Emi | last4=Savoia | first4=Francesco | title=Cauliflower-like exophytic mass on the skin: polypoid melanoma. Clinical, dermoscopic, and histologic features | journal=Anais Brasileiros de Dermatologia | publisher=Elsevier BV | volume=95 | issue=6 | year=2020 | issn=0365-0596 | doi=10.1016/j.abd.2020.04.010 | pages=748–750| pmid=33041156 | pmc=7672400 }}
Treatment
Therapies for metastatic melanoma include the biological immunotherapy agents ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and an MEK inhibitor trametinib.{{cite journal |vauthors=Maverakis E, Cornelius LA, Bowen GM, Phan T, Patel FB, Fitzmaurice S, He Y, Burrall B, Duong C, Kloxin AM, Sultani H, Wilken R, Martinez SR, Patel F | title = Metastatic melanoma — a review of current and future treatment options | journal = Acta Derm Venereol | volume = 95 | issue = 5 | pages = 516–524 | year = 2015 | pmid = 25520039 | doi = 10.2340/00015555-2035|url=http://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=4849&context=open_access_pubs | doi-access = free }}
See also
References
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Further reading
- {{cite journal | last1=Hikawa | first1=Renato Shintani | last2=Kanehisa | first2=Eliza Sayuri | last3=Enokihara | first3=Mílvia Maria Simões e Silva | last4=Enokihara | first4=Mauro Yoshiaki | last5=Hirata | first5=Sérgio Henrique | title=Polypoid melanoma and superficial spreading melanoma different subtypes in the same lesion | journal=Anais Brasileiros de Dermatologia | publisher=FapUNIFESP (SciELO) | volume=89 | issue=4 | year=2014 | issn=0365-0596 | doi=10.1590/abd1806-4841.20142802 | pages=666–668 | pmid=25054761 | pmc=4148288 | ref=none}}
- {{cite journal | last1=Manci | first1=Elizabeth A. | last2=Balch | first2=Charles M. | last3=Murad | first3=Tariq M. | last4=Seng/Jaw | first4=Soong | title=Polypoid Melanoma, A Virulent Variant of the Nodular Growth Pattern | journal=American Journal of Clinical Pathology | publisher=Oxford University Press (OUP) | volume=75 | issue=6 | date=June 1, 1981 | issn=0002-9173 | doi=10.1093/ajcp/75.6.810 | pages=810–815 | pmid=7258141 | ref=none}}
External links
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{{Skin tumors, nevi and melanomas}}