Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series

! width="5%" | Year

! width="25%" | Actress

! width="30%" | Role

! width="35%" | Program

! width="5%" | Network

| style="background:#FAEB86"| Eve Arden

| style="background:#FAEB86" | Connie Brooks

| style="background:#FAEB86"| Our Miss Brooks

| style="background:#FAEB86"| CBS

| rowspan="3"|NBC

| rowspan="4"|CBS

| rowspan="2"|CBS

| rowspan="3"|CBS

| Jane Wyatt

| Margaret Anderson

| Father Knows Best

| CBS & NBC

| Gracie Allen

| The George Burns and Gracie Allen Show

| rowspan=3|CBS

| Lily Ruskin

| December Bride

| Eve Adams

| Mr. Adams and Eve

| Donna Stone

| The Donna Reed Show

| ABC

| Katy O'Connor

| The Ann Sothern Show

| CBS

! width="5%" | Year

! width="25%" | Actress

! width="30%" | Role

! width="35%" | Program

! width="5%" | Network

| rowspan="2"|CBS

| rowspan="4"|CBS

| Leonard Bernstein

| Conductor

| New York Philharmonic Young People's Concerts with Leonard Bernstein

| CBS

| Lynn Fontanne

| Fanny Bowditch Holmes

| rowspan="2"|Hallmark Hall of Fame: "The Magnificent Yankee"

| rowspan="2"|NBC

| Alfred Lunt

| Oliver Wendell Holmes Jr.

| Barbra Streisand

| Herself

| My Name Is Barbra

| rowspan="2"|CBS

| Dick Van Dyke

| Rob Petrie

| The Dick Van Dyke Show

| Herself

| The Andy Williams Show: "November 30, 1964"

| rowspan="4"|NBC

| Host

| The Tonight Show Starring Johnny Carson

| Margaret St. Clair

| rowspan="2"|The Rogues

| Timmy St. Clair

| James Slattery

| Slattery's People

| CBS

| Florence Nightingale

| Hallmark Hall of Fame: "The Holy Terror"

| rowspan="3"|NBC

| Himself

| Chrysler Presents A Bob Hope Comedy Special

| Principal Albert Vane

| Mr. Novak

| Host

| The Danny Kaye Show

| CBS

| Illya Kuryakin

| The Man from U.N.C.L.E.

| NBC

| Himself

| The Red Skelton Hour

| CBS

| Mary Tyler Moore

| Laura Petrie

| The Dick Van Dyke Show

| CBS

| Lucy Carmichael

| The Lucy Show

| CBS

| Samantha Stephens

| Bewitched

| ABC

| Lucille Ball

| Lucy Carmichael

| The Lucy Show

| CBS

| Samantha Stephens

| rowspan=2|Bewitched

| rowspan=3|ABC

| Endora

| Ann Marie

| That Girl

| Lucille Ball

| Lucy Carmichael

| The Lucy Show

| CBS

| Agent 99

| Get Smart

| NBC

| Samantha Stephens

| Bewitched

| ABC

| Paula Hollister

| He & She

| CBS

| Ann Marie

| That Girl

| ABC

| Hope Lange

| Carolyn Muir

| The Ghost & Mrs. Muir

| NBC

| Julia Baker

| Julia

| rowspan=2|NBC

| Agent 99

| Get Smart

| Samantha Stephens

| Bewitched

| ABC

! width="5%" | Year

! width="25%" | Actress

! width="30%" | Role

! width="35%" | Program

! width="5%" | Network

| Hope Lange

| Carolyn Muir

| The Ghost & Mrs. Muir

| ABC

| Samantha Stephens

| Bewitched

| rowspan=2|ABC

| Ann Marie

| That Girl

| Jean Stapleton

| Edith Bunker

| All in the Family

| CBS

| Ann Marie

| That Girl

| ABC

| Mary Richards

| The Mary Tyler Moore Show

| CBS

| Jean Stapleton

| Edith Bunker

| All in the Family

| CBS

| Sandy Stockton

| Funny Face

| rowspan=2|CBS

| Mary Richards

| The Mary Tyler Moore Show

| Mary Tyler Moore

| Mary Richards

| The Mary Tyler Moore Show

| CBS

| Edith Bunker

| All in the Family

| rowspan=2|CBS

| Maude Findlay

| Maude

| Mary Tyler Moore

| Mary Richards

| The Mary Tyler Moore Show

| CBS

| Maude Findlay

| Maude

| rowspan=2|CBS

| Edith Bunker

| All in the Family

| Valerie Harper

| Rhoda Morgenstern

| Rhoda

| CBS

| Edith Bunker

| All in the Family

| rowspan=2|CBS

| Mary Richards

| The Mary Tyler Moore Show

| Mary Tyler Moore

| Mary Richards

| The Mary Tyler Moore Show

| CBS

| Fay Stewart

| Fay

| NBC

| Maude Findlay

| Maude

| rowspan=3|CBS

| Phyllis Lindstrom

| Phyllis

| Rhoda Morgenstern

| Rhoda

| Bea Arthur

| Maude Findlay

| Maude

| CBS

| Edith Bunker

| All in the Family

| rowspan=4|CBS

| Rhoda Morgenstern

| Rhoda

| Emily Hartley

| The Bob Newhart Show

| Mary Richards

| The Mary Tyler Moore Show

| Jean Stapleton

| Edith Bunker

| All in the Family

| CBS

| Maude Findlay

| Maude

| rowspan=2|CBS

| Rhoda Morgenstern

| Rhoda

| Mary Campbell

| rowspan=2|Soap

| rowspan=2|ABC

| Jessica Tate

| Emily Hartley

| The Bob Newhart Show

| CBS

| Ruth Gordon §

| Dee Wilcox

| Taxi

| ABC

| Alice Hyatt

| Alice

| rowspan=2|CBS

| Edith Bunker

| All in the Family

| Jessica Tate

| Soap

| ABC

| Louise Jefferson

| The Jeffersons

| CBS

! width="5%" | Year

! width="20%" | Actress

! width="20%" | Role

! width="25%" | Program

! width="25%" | Episode Submissions

! width="5%" | Network

| Cathryn Damon

| Mary Campbell

| Soap

| {{n/a}}

| ABC

| Flo Castleberry

| Flo

| {{n/a}}

| rowspan=3|CBS

| Dotty Wertz

| Archie Bunker's Place

| {{n/a}}

| Louise Jefferson

| The Jeffersons

| {{n/a}}

| Jessica Tate

| Soap

| {{n/a}}

| ABC

| Isabel Sanford

| Louise Jefferson

| The Jeffersons

| "And the Doorknobs Shined Like Diamonds"

| CBS

| Mrs. McKenzie

| Taxi

| "Thy Boss's Wife"

| rowspan=3|ABC

| Mary Campbell

| rowspan=2|Soap

| {{n/a}}

| Jessica Tate

| {{n/a}}

| Ann Atkinson

| House Calls

| {{n/a}}

| CBS

| Carol Kane §

| Simka Dahblitz

| Taxi

| "Simka Returns"

| ABC

| Laurie Morgan

| Love, Sidney

| {{n/a}}

| rowspan=3|NBC

| Nellie Harper

| Gimme a Break!

| {{n/a}}

| Edna Garrett

| The Facts of Life

| {{n/a}}

| Ann Romano

| One Day at a Time

| {{n/a}}

| rowspan="2"|CBS

| Louise Jefferson

| The Jeffersons

| {{n/a}}

| Shelley Long

| Diane Chambers

| Cheers

| "Give Me a Ring Sometime"

| NBC

| Jennifer Barnes

| Goodnight, Beantown

| {{n/a}}

| rowspan="2"|CBS

| Louise Jefferson

| The Jeffersons

| {{n/a}}

| Nellie Harper

| Gimme a Break!

| {{n/a}}

| rowspan="2"|NBC

| Laurie Morgan

| Love, Sidney

| {{n/a}}

| Violet Newstead

| 9 to 5

| {{n/a}}

| ABC

| Jane Curtin

| Allie Lowell

| Kate & Allie

| {{n/a}}

| CBS

| Jo Jo White

| Buffalo Bill

| {{n/a}}

| rowspan=2|NBC

| Diane Chambers

| Cheers

| {{n/a}}

| Kate McArdle

| Kate & Allie

| {{n/a}}

| rowspan=2|CBS

| Louise Jefferson

| The Jeffersons

| {{n/a}}

| Jane Curtin

| Allie Lowell

| Kate & Allie

| {{n/a}}

| CBS

| Diane Chambers

| Cheers

| {{n/a}}

| rowspan=2|NBC

| Clair Huxtable

| The Cosby Show

| {{n/a}}

| Kate McArdle

| Kate & Allie

| {{n/a}}

| rowspan=2|CBS

| Louise Jefferson

| The Jeffersons

| {{n/a}}

| Betty White

| Rose Nylund

| The Golden Girls

| "In a Bed of Rose's"

| NBC

| Diane Chambers

| Cheers

| {{n/a}}

| rowspan=4|NBC

| Dorothy Zbornak

| rowspan="2"|The Golden Girls

| "The Triangle"

| Blanche Devereaux

| "The Way We Met"

| Clair Huxtable

| The Cosby Show

| "Cliff in Love"

| Rue McClanahan

| Blanche Devereaux

| The Golden Girls

| "End of the Curse"

| NBC

| Molly Bickford Dodd

| The Days and Nights of Molly Dodd

| {{n/a}}

| rowspan=3|NBC

| Dorothy Zbornak

| rowspan="2"|The Golden Girls

| "The Stan Who Came to Dinner"

| Rose Nylund

| "Isn't It Romantic?"

| Allie Lowell

| Kate & Allie

| {{n/a}}

| CBS

| Bea Arthur

| Dorothy Zbornak

| The Golden Girls

| "My Brother, My Father"

| NBC

| Rebecca Howe

| Cheers

| "Backseat Becky, Upfront"

| rowspan=4|NBC

| Molly Bickford Dodd

| The Days and Nights of Molly Dodd

| {{n/a}}

| Blanche Devereaux

| rowspan=2|The Golden Girls

| "Strange Bedfellows"

| Rose Nylund

| "Bringing Up Baby"

| Candice Bergen

| Murphy Brown

| Murphy Brown

| "Respect"

| CBS

| Molly Bickford Dodd

| The Days and Nights of Molly Dodd

| {{n/a}}

| Lifetime

| Blanche Devereaux

| rowspan=3|The Golden Girls

| "Yes, We Have No Havanas"

| rowspan=3|NBC

| Rose Nylund

| "High Anxiety"

| Dorothy Zbornak

| "Love Me Tender"

! width="5%" | Year

! width="20%" | Actress

! width="20%" | Role

! width="25%" | Program

! width="25%" | Episode Submissions

! width="5%" | Network

| Candice Bergen

| Murphy Brown

| Murphy Brown

| "Brown Like Me"

| CBS

| Rebecca Howe

| Cheers

| "The Improbable Dream, Part 1"

| rowspan="2"|NBC

| Rose Nylund

| The Golden Girls

| "Rose Fights Back"

| Molly Bickford Dodd

| The Days and Nights of Molly Dodd

| {{n/a}}

| Lifetime

| Suzanne Sugarbaker

| Designing Women

| "They Shoot Fat Women, Don't They?"

| CBS

| Kirstie Alley

| Rebecca Howe

| Cheers

| "The Days of Wine and Neuroses"

| NBC

| Murphy Brown

| Murphy Brown

| "On Another Plane"

| rowspan="2"|CBS

| Suzanne Sugarbaker

| Designing Women

| "The Bachelor Auction"

| Molly Bickford Dodd

| The Days and Nights of Molly Dodd

| "Here's a Pregnant Pause"

| Lifetime

| Rose Nylund

| The Golden Girls

| "Once, in St. Olaf"

| NBC

| Candice Bergen

| Murphy Brown

| Murphy Brown

| "Birth 101"

| CBS

| Roseanne Conner

| Roseanne

| "A Bitter Pill to Swallow"

| ABC

| Rebecca Howe

| Cheers

| "An Old Fashioned Wedding"

| rowspan="3"|NBC

| Mimsy Borogroves

| Wings

| "My Brother's Keeper"

| Rose Nylund

| The Golden Girls

| "Dateline: Miami"

| Sophie Berger

| Brooklyn Bridge

| "Brave New World"

| CBS

| Roseanne Barr

| Roseanne Conner

| Roseanne

| "Wait Till Your Father Gets Home"

| ABC

| Murphy Brown

| Murphy Brown

| "Games Mothers Play"

| rowspan="2"|CBS

| Sophie Berger

| Brooklyn Bridge

| "Brave New Worlds"

| Rebecca Howe

| Cheers

| "One for the Road"

| rowspan="2"|NBC

| Jamie Buchman

| Mad About You

| "Pilot"

| Candice Bergen

| Murphy Brown

| Murphy Brown

| "It's Just Like Riding a Bike"

| CBS

| Jamie Buchman

| Mad About You

| "Cold Feet"

| NBC

| Dana Palladino

| Love & War

| "I've Got a Crush on You"

| CBS

| Roseanne Conner

| Roseanne

| "The Driver's Seat"

| rowspan="2"|ABC

| Jill Taylor

| Home Improvement

| "The Colonel"

| Candice Bergen

| Murphy Brown

| Murphy Brown

| "Requiem for a Crew Guy"

| CBS

| Roseanne Conner

| Roseanne

| "Thanksgiving 1994"

| rowspan=2|ABC

| Ellen Morgan

| Ellen

| "The Spa"

| Jamie Buchman

| Mad About You

| "The Ride Home"

| NBC

| Cybill Sheridan

| Cybill

| "Virgin, Mother, Crone"

| CBS

| Helen Hunt

| Jamie Buchman

| Mad About You

| "The Finale"

| NBC

| Ellen Morgan

| Ellen

| "Witness"

| ABC

| Fran Fine

| The Nanny

| "The Hockey Show"

| rowspan="2"|CBS

| Cybill Sheridan

| Cybill

| "When You're Hot, You're Hot"

| Jill Taylor

| Home Improvement

| "The Longest Day"

| ABC

| Helen Hunt

| Jamie Buchman

| Mad About You

| "The Birth"

| NBC

| Ellen Morgan

| Ellen

| "The Puppy Episode"

| rowspan="2"|ABC

| Jill Taylor

| Home Improvement

| "Family Unties"

| Fran Fine

| The Nanny

| "The Facts of Lice"

| rowspan="2"|CBS

| Cybill Sheridan

| Cybill

| "In Her Dreams"

| Helen Hunt

| Jamie Buchman

| Mad About You

| "Moody Blues"

| NBC

| Ellen Morgan

| Ellen

| "Neighbors"

| rowspan=3|ABC

| Dharma Montgomery

| Dharma & Greg

| "Haus Arrest"

| Jill Taylor

| Home Improvement

| "Bright Christmas"

| Veronica Chase

| Veronica's Closet

| "Pilot"

| NBC

| Ally McBeal

| Ally McBeal

| "One Hundred Tears Away"

| Fox

| Helen Hunt

| Jamie Buchman

| Mad About You

| "The Final Frontier"

| NBC

| Dharma Montgomery

| Dharma & Greg

| "Are You Ready for Some Football?"

| ABC

| Ally McBeal

| Ally McBeal

| "Sideshow"

| Fox

| Debra Barone

| Everybody Loves Raymond

| "Be Nice"

| CBS

| Carrie Bradshaw

| Sex and the City

| "The Drought"

| HBO

! width="5%" | Year

! width="20%" | Actress

! width="20%" | Role

! width="25%" | Program

! width="25%" | Episode Submissions

! width="5%" | Network

| Patricia Heaton

| Debra Barone

| Everybody Loves Raymond

| "Bad Moon Rising"

| CBS

| Dharma Montgomery

| Dharma & Greg

| "Lawyers, Beer, and Money"

| ABC

| Lois

| Malcolm in the Middle

| "Red Dress"

| Fox

| Grace Adler

| Will & Grace

| "Das Boob"

| NBC

| Carrie Bradshaw

| Sex and the City

| "Ex and the City"

| HBO

| Patricia Heaton

| Debra Barone

| Everybody Loves Raymond

| "The Canister"

| CBS

| Ally McBeal

| Ally McBeal

| "Falling Up"

| rowspan=2|Fox

| Lois

| Malcolm in the Middle

| "Flashback"

| Grace Adler

| Will & Grace

| "Lows in the Mid-Eighties"

| NBC

| Carrie Bradshaw

| Sex and the City

| "Don't Ask, Don't Tell"

| HBO

| Jennifer Aniston

| Rachel Green

| Friends

| "The One Where Rachel Has a Baby"

| NBC

| Debra Barone

| Everybody Loves Raymond

| "A Vote for Debra"

| CBS

| Lois

| Malcolm in the Middle

| "Poker"

| Fox

| Grace Adler

| Will & Grace

| "Bed, Bath and Beyond"

| NBC

| Carrie Bradshaw

| Sex and the City

| "The Real Me"

| HBO

| Debra Messing

| Grace Adler

| Will & Grace

| "The Kid Stays Out of the Picture"

| NBC

| Rachel Green

| Friends

| "The One Where Monica Sings"

| NBC

| Debra Barone

| Everybody Loves Raymond

| "Baggage"

| CBS

| Lois

| Malcolm in the Middle

| "Baby"

| Fox

| Carrie Bradshaw

| Sex and the City

| "Anchors Away"

| HBO

| Sarah Jessica Parker

| Carrie Bradshaw

| Sex and the City

| "An American Girl in Paris (Part Deux)"

| HBO

| Rachel Green

| Friends

| "The One with Rachel's Going Away Party"

| NBC

| Debra Barone

| Everybody Loves Raymond

| "Fun with Debra"

| CBS

| Bonnie Malloy

| Life with Bonnie

| "Ironing Out Our Differences"

| ABC

| Lois

| Malcolm in the Middle

| "Block Party"

| Fox

| Felicity Huffman

| Lynette Scavo

| Desperate Housewives

| "Pilot"

| ABC

| Bree Van de Kamp

| rowspan="2"|Desperate Housewives

| "Running to Stand Still"

| rowspan="2"|ABC

| Susan Mayer

| "Move On"

| Debra Barone

| Everybody Loves Raymond

| "The Finale"

| CBS

| Lois

| Malcolm in the Middle

| "Lois Battles Jamie"

| Fox

| Julia Louis-Dreyfus

| Christine Campbell

| The New Adventures of Old Christine

| "Supertramp"

| CBS

| Lydia Barnes

| Out of Practice

| "And I'll Cry If I Want To"

| CBS

| Lois

| Malcolm in the Middle

| "Lois Strikes Back"

| Fox

| Valerie Cherish

| The Comeback

| "Valerie Does Another Classic Leno"

| HBO

| Grace Adler

| Will & Grace

| "The Finale"

| NBC

| America Ferrera

| Betty Suarez

| Ugly Betty

| "Pilot"

| ABC

| Liz Lemon

| 30 Rock

| "Up All Night"

| NBC

| Lynette Scavo

| Desperate Housewives

| "Bang"

| ABC

| Christine Campbell

| The New Adventures of Old Christine

| "Playdate with Destiny"

| CBS

| Nancy Botwin

| Weeds

| "Mrs. Botwin's Neighborhood"

| Showtime

| Tina Fey

| Liz Lemon

| 30 Rock

| "Sandwich Day"

| NBC

| Samantha Newly

| Samantha Who?

| "The Restraining Order"

| rowspan=2|ABC

| Betty Suarez

| Ugly Betty

| "Odor in the Court"

| Christine Campbell

| The New Adventures of Old Christine

| "One and a Half Men"

| CBS

| Nancy Botwin

| Weeds

| "Bill Sussman"

| Showtime

| Toni Collette

| Tara Gregson

| United States of Tara

| "Pilot"

| Showtime

| Samantha Newly

| Samantha Who?

| "The Pill"

| ABC

| Liz Lemon

| 30 Rock

| "Reunion"

| NBC

| Christine Campbell

| The New Adventures of Old Christine

| "Everyone Says I Love You Except Richie"

| CBS

| Nancy Botwin

| Weeds

| "Lady's a Charm"

| Showtime

| Sarah Silverman

| The Sarah Silverman Program

| "There's No Place Like Homeless"

| Comedy Central

! style="width:5%;"| Year

! style="width:18%;"| Actress

! style="width:18%;" | Role

! style="width:23%;"| Program

! style="width:23%;"| Episode Submissions

! style="width:13%;"| Network

| Edie Falco

| Jackie Peyton

| Nurse Jackie

| "Pilot"

| Showtime

| Liz Lemon

| 30 Rock

| "Dealbreakers Talk Show#0001"

| rowspan="2"|NBC

| Leslie Knope

| Parks and Recreation

| "Telethon"

| Tara Gregson

| United States of Tara

| "Torando!"

| Showtime

| Christine Campbell

| The New Adventures of Old Christine

| "I Love What You Do for Me"

| CBS

| Rachel Berry

| Glee

| "Sectionals"

| Fox

| Melissa McCarthy

| Molly Flynn

| Mike & Molly

| "First Date"

| CBS

| Jackie Peyton

| Nurse Jackie

| "Rat Falls"

| Showtime

| Liz Lemon

| 30 Rock

| "Double-Edged Sword"

| NBC

| Cathy Jamison

| The Big C

| "Pilot"

| Showtime

| Virginia Chance

| Raising Hope

| "Say Cheese"

| Fox

| Leslie Knope

| Parks and Recreation

| "Flu Season"

| NBC

| Julia Louis-Dreyfus

| Selina Meyer

| Veep

| "Tears"

| HBO

| Jessica Day

| New Girl

| "Bad in Bed"

| Fox

| Hannah Horvath

| Girls

| "She Did"

| HBO

| Jackie Peyton

| Nurse Jackie

| "Disneyland Sucks"

| Showtime

| Liz Lemon

| 30 Rock

| "The Tuxedo Begins"

| NBC

| Molly Flynn

| Mike & Molly

| "The Dress"

| CBS

| Leslie Knope

| Parks and Recreation

| "Win, Lose, or Draw"

| NBC

| Julia Louis-Dreyfus

| Selina Meyer

| Veep

| "Running"

| HBO

| Amy Jellicoe

| Enlightened

| "All I Ever Wanted"

| rowspan=2|HBO

| Hannah Horvath

| Girls

| "Bad Friend"

| Jackie Peyton

| Nurse Jackie

| "Luck of the Drawing"

| Showtime

| Liz Lemon

| 30 Rock

| "Hogcock!" + "Last Lunch"

| rowspan=2|NBC

| Leslie Knope

| Parks and Recreation

| "Emergency Response" + "Leslie and Ben"

| Julia Louis-Dreyfus

| Selina Meyer

| Veep

| "Crate"

| HBO

| Hannah Horvath

| Girls

| "Beach House"

| HBO

| Jackie Peyton

| Nurse Jackie

| "Super Greens"

| Showtime

| Molly Flynn

| Mike & Molly

| "Mind Over Molly"

| CBS

| Leslie Knope

| Parks and Recreation

| "Recall Vote"

| NBC

| Piper Chapman

| Orange Is the New Black

| "The Chickening"

| Netflix

| Julia Louis-Dreyfus

| Selina Meyer

| Veep

| "Election Night"

| HBO

| Jackie Peyton

| Nurse Jackie

| "I Say a Little Prayer"

| Showtime

| Valerie Cherish

| The Comeback

| "Valerie Is Taken Seriously"

| HBO

| Leslie Knope

| Parks and Recreation

| "One Last Ride"

| NBC

| Various characters

| Inside Amy Schumer

| "Cool With It"

| Comedy Central

| Frankie Bergstein

| Grace and Frankie

| "The Vows"

| Netflix

| Julia Louis-Dreyfus

| Selina Meyer

| Veep

| "Mother"

| HBO

| Kimmy Schmidt

| Unbreakable Kimmy Schmidt

| "Kimmy Goes to a Hotel!"

| Netflix

| Dr. Jenna James

| Getting On

| "Am I Still Me?"

| HBO

| Dr. Rainbow Johnson

| Black-ish

| "Sink or Swim"

| ABC

| Various characters

| Inside Amy Schumer

| "Welcome to the Gun Show"

| Comedy Central

| Frankie Bergstein

| Grace and Frankie

| "The Test"

| Netflix

| Julia Louis-Dreyfus

| Selina Meyer

| Veep

| "Groundbreaking"

| HBO

| Sam Fox

| Better Things

| "Future Fever"

| FX

| Bonnie Plunkett

| Mom

| "Tush Push and Some Radishes"

| CBS

| Kimmy Schmidt

| Unbreakable Kimmy Schmidt

| "Kimmy Goes to College!"

| rowspan="2"|Netflix

| Grace Hanson

| Grace and Frankie

| "The Pot"

| Dr. Rainbow Johnson

| Black-ish

| "Being Bow-racial"

| ABC

| Frankie Bergstein

| Grace and Frankie

| "The Burglary"

| Netflix

| Rachel Brosnahan

| Miriam "Midge" Maisel

| The Marvelous Mrs. Maisel

| "Thank You and Good Night"

| Amazon

| Sam Fox

| Better Things

| "Eulogy"

| FX

| Bonnie Plunkett

| Mom

| "Phone Confetti and a Wee Dingle"

| CBS

| Issa Dee

| Insecure

| "Hella Great"

| HBO

| Dr. Rainbow Johnson

| Black-ish

| "Elder. Scam."

| ABC

| Frankie Bergstein

| Grace and Frankie

| "The Home"

| Netflix

| Phoebe Waller-Bridge

| Fleabag

| Fleabag

| "Episode 1"

| Amazon

| Jen Harding

| Dead to Me

| "I've Gotta Get Away"

| Netflix

| Miriam "Midge" Maisel

| The Marvelous Mrs. Maisel

| "Midnight at the Concord"

| Amazon

| Selina Meyer

| Veep

| "Veep"

| HBO

| Nadia Vulvokov

| Russian Doll

| "Nothing in This World Is Easy"

| Netflix

| Moira Rose

| Schitt's Creek

| "The Crowening"

| Pop TV

! style="width:5%;"| Year

! style="width:20%;"| Actress

! style="width:20%;" | Role

! style="width:20%;"| Program

! style="width:23%;"| Episode Submission

! style="width:12%;"| Network

| Catherine O'Hara

| Moira Rose

| Schitt's Creek

| "The Incident"

| Pop TV

| Jen Harding

| Dead to Me

| "It's Not You, It's Me"

| Netflix

| Miriam "Midge" Maisel

| The Marvelous Mrs. Maisel

| "A Jewish Girl Walks Into the Apollo..."

| Amazon

| Judy Hale

|Dead to Me

| "If Only You Knew"

| Netflix

| Issa Dee

| Insecure

| "Lowkey Happy"

| HBO

| Dr. Rainbow Johnson

| Black-ish

| "Kid Life Crisis"

| ABC

| Jean Smart

| Deborah Vance

| Hacks

| "1.69 Million"

| HBO Max

| Annie Easton

| Shrill

| "Ranchers"

| Hulu

| Cassie Bowden

| The Flight Attendant

| "In Case of Emergency"

| HBO Max

| Bonnie Plunkett

| Mom

| "My Kinda People and the Big To-Do"

| CBS

| Dr. Rainbow Johnson

| Black-ish

| "Babes in Boyland"

| ABC

| Jean Smart

| Deborah Vance

| Hacks

| "The Click"

| HBO Max

| Miriam "Midge" Maisel

| The Marvelous Mrs. Maisel

| "How Do You Get to Carnegie Hall?"

| Prime Video

| Janine Teagues

| Abbott Elementary

| "Pilot"

| ABC

| Cassie Bowden

| The Flight Attendant

| "Drowning Women"

| HBO Max

| Catherine the Great

| The Great

| "Alone at Last"

| Hulu

| Issa Dee

| Insecure

| "Reunited, Okay?!"

| HBO

| Quinta Brunson

| Janine Teagues

| Abbott Elementary

| "Teacher Conference"

| ABC

| Jen Harding

| Dead to Me

| "We've Reached the End"

| Netflix

| Miriam "Midge" Maisel

| The Marvelous Mrs. Maisel

| "Four Minutes"

| Prime Video

| Charlie Cale

| Poker Face

| "Dead Man's Hand"

| Peacock

| Wednesday Addams / Goody Addams

| Wednesday

| "Friend or Woe"

| Netflix

| Jean Smart

| Deborah Vance

| Hacks

| "Yes, And"

| Max

| Janine Teagues

| Abbott Elementary

|"Party"

| ABC

| Sydney Adamu

| The Bear

|"Sundae"

| FX

| Mabel Mora

| Only Murders in the Building

|"Ghost Light"

| Hulu

| Molly Novak

| Loot

|"Space for Everyone"

| rowspan="2"|Apple TV+

| Maxine Dellacorte-Simmons

| Palm Royale

|"Maxine Throws a Party"

!width="350"|Superlative

! colspan="2" width="290"| Outstanding Lead Actress in a Comedy Series

! width="350"| Actress with most awards

|Julia Louis-Dreyfus (7)

! Actress with most nominations

|Julia Louis-Dreyfus (12)

! Actress with most nominations
without ever winning

|Jane Kaczmarek (7)