Pro-opiomelanocortin converting enzyme

{{Infobox enzyme

| Name = Pro-opiomelanocortin converting enzyme

| EC_number = 3.4.23.17

| CAS_number = 80891-34-5

| GO_code =

| image =

| width =

| caption =

}}

Pro-opiomelanocortin converting enzyme ({{EC number|3.4.23.17}}, prohormone converting enzyme, pro-opiomelanocortin-converting enzyme, proopiomelanocortin proteinase, PCE) is an enzyme.{{cite journal | vauthors = Loh YP, Parish DC, Tuteja R | title = Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles | journal = The Journal of Biological Chemistry | volume = 260 | issue = 12 | pages = 7194–205 | date = June 1985 | pmid = 2987247 }}{{cite journal | vauthors = Loh YP | title = Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme | journal = The Journal of Biological Chemistry | volume = 261 | issue = 26 | pages = 11949–55 | date = September 1986 | pmid = 3017955 }}{{cite journal | vauthors = Estivariz FE, Birch NP, Loh YP | title = Generation of Lys-gamma 3-melanotropin from pro-opiomelanocortin 1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme | journal = The Journal of Biological Chemistry | volume = 264 | issue = 30 | pages = 17796–801 | date = October 1989 | pmid = 2553692 }} This enzyme catalyses the following chemical reaction

: Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side

This membrane-bound enzyme is isolated from cattle pituitary secretory vesicle.