Prolactin-releasing peptide

PrRP has 20 amino acids, and is a member of the RFamide peptide family.

During the discovery process, PrRP was found to be a ligand for an orphan G-protein coupled receptor (GPR 10). Preliminary in vitro studies showed it to stimulate the secretion of prolactin from lactotropic cells, hence its name. Now, however, the function of PrRP in the brain is understood in terms of negative regulation of appetite.{{cite book |last1=Brunton |first1=Paula |last2=Russell |first2=John |date=2015 |title=Physiology of Reproduction |url=https://www.sciencedirect.com/book/9780123971753/knobil-and-neills-physiology-of-reproduction |publisher=Academic Press |doi=10.1016/C2011-1-07288-0 |isbn=978-0-12-397175-3 |access-date=April 29, 2020|edition=Fourth }} ([https://www.sciencedirect.com/topics/neuroscience/prolactin-releasing-peptide This extract is more helpful.])

PrRP is produced by noradrenergic neurons A1 and A2 in the solitary nucleus, and also by neurons in the hypothalamus.

{{reflist}}

{{refbegin | 2}}

• {{cite journal |vauthors=Hinuma S, Onda H, Fujino M |title=The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors. |journal=J. Mol. Med. |volume=77 |issue= 6 |pages= 495–504 |year= 1999 |pmid= 10475064 |doi=10.1007/s001090050403 |s2cid=19633923 }}
• {{cite journal |vauthors=Lagerström MC, Fredriksson R, Bjarnadottir TK, Schiöth HB |title=The ancestry of the prolactin-releasing hormone precursor. |journal=Ann. N. Y. Acad. Sci. |volume=1040 |pages= 368–70 |year= 2006 |issue=1 |pmid= 15891064 |doi= 10.1196/annals.1327.064 |s2cid=45949972 }}
• {{cite journal |vauthors=Hinuma S, Habata Y, Fujii R, etal |title=A prolactin-releasing peptide in the brain. |journal=Nature |volume=393 |issue= 6682 |pages= 272–6 |year= 1998 |pmid= 9607765 |doi= 10.1038/30515 |bibcode=1998Natur.393..272H |s2cid=4306854 }}
• {{cite journal |vauthors=Fujii R, Fukusumi S, Hosoya M, etal |title=Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor. |journal=Regul. Pept. |volume=83 |issue= 1 |pages= 1–10 |year= 1999 |pmid= 10498338 |doi=10.1016/S0167-0115(99)00028-2 |s2cid=45945978 }}
• {{cite journal |vauthors=Zhang X, Danila DC, Katai M, etal |title=Expression of prolactin-releasing peptide and its receptor messenger ribonucleic acid in normal human pituitary and pituitary adenomas. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 12 |pages= 4652–5 |year= 2000 |doi=10.1210/jcem.84.12.6191 |pmid= 10599733 |s2cid=18892388 |doi-access=free }}
• {{cite journal |vauthors=Yasui Y, Yamaguchi M, Jikihara H, etal |title=Expression of prolactin-releasing peptide in human placenta and decidua |journal=Endocr. J. |volume=48 |issue= 3 |pages= 397–401 |year= 2002 |pmid= 11523913 |doi=10.1507/endocrj.48.397 |doi-access=free }}
• {{cite journal |vauthors=Takahashi K, Totsune K, Murakami O, etal |title=Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas |journal=Peptides |volume=23 |issue= 6 |pages= 1135–40 |year= 2003 |pmid= 12126742 |doi=10.1016/S0196-9781(02)00046-3 |s2cid=24182099 }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

{{refend}}

{{gene-2-stub}}