Promegapoietin

{{Short description|Drug given during chemotherapy to increase blood cell regeneration}}

Promegapoietin is a drug given during chemotherapy to increase blood cell regeneration. It is a colony-stimulating factor that stimulates megakaryocyte production.{{cite journal |vauthors=Kratz-Albers K, Scheding S, Möhle R, Bühring H, Baum C, Mc Kearn J, Büchner T, Kanz L, Brugger W |title=Effective ex vivo generation of megakaryocytic cells from mobilized peripheral blood CD34(+) cells with stem cell factor and promegapoietin |journal=Exp Hematol |volume=28 |issue=3 |pages=335–46 |year=2000 |pmid=10720698 |doi=10.1016/S0301-472X(99)00152-6|doi-access=free }}[http://www.cancer.gov/dictionary?CdrID=46019 Definition of promegapoietin – NCI Dictionary of Cancer Terms]

It functions by stimulating ligands for interleukin 3 and c-Mpl.{{cite journal |vauthors=Doshi P, Giri J, Abegg A, Favara J, Huynh M, Kahn L, Minnerly J, Pegg L, Villani-Price D, Siegel N, Staten N, Thomas J, McKearn J, Smith W |title=Promegapoietin, a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling pathways |journal=Exp Hematol |volume=29 |issue=10 |pages=1177–84 |year=2001 |pmid=11602319 |doi=10.1016/S0301-472X(01)00694-4|doi-access=free }}