Propoxur

{{chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 459451584

| ImageFile = Propoxur.png

| ImageAlt = Skeletal formula of propoxur

| ImageFile1 = Propoxur-3D-balls.png

| ImageSize1 = 220

| ImageAlt1 = Ball-and-stick model of the propoxur molecule

| PIN = 2-[(Propan-2-yl)oxy]phenyl methylcarbamate

| OtherNames =

|Section1={{Chembox Identifiers

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo = 114-26-1

| PubChem = 4944

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 4775

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = C14334

| ChEBI_Ref = {{ebicite|changed|EBI}}

| ChEBI = 34938

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 446060

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = BFH029TL73

| SMILES = CC(C)Oc1ccccc1OC(=O)NC

| StdInChI = 1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13)

| StdInChIKey = ISRUGXGCCGIOQO-UHFFFAOYSA-N

}}

|Section2={{Chembox Properties

| C=11 | H=15 | N=1 | O=3

| Appearance = White to tan crystalline powder

| Odor = faint, characteristic

| Density =

| MeltingPtF = 187 to 197

| BoilingPt = decomposes

| Solubility = 0.2% (20°C)

| VaporPressure = 0.0000937 mmHg (20 °C)

}}

|Section6={{Chembox Pharmacology

| ATCvet = yes

| ATCCode_prefix = P53

| ATCCode_suffix = AE02

}}

|Section7={{Chembox Hazards

| MainHazards =

| FlashPt = >

| FlashPtF = 300

| AutoignitionPt =

| PEL = none{{PGCH|0531}}

| IDLH = N.D.

| REL = TWA 0.5 mg/m3

}}

}}

Propoxur (Baygon) is a carbamate non-systemic insecticide, produced from catechol,{{Ullmann |doi=10.1002/14356007.a19_313|title=Phenol Derivatives |year=2000 |last1=Fiege |first1=Helmut |last2=Voges |first2=Heinz-Werner |last3=Hamamoto |first3=Toshikazu |last4=Umemura |first4=Sumio |last5=Iwata |first5=Tadao |last6=Miki |first6=Hisaya |last7=Fujita |first7=Yasuhiro |last8=Buysch |first8=Hans-Josef |last9=Garbe |first9=Dorothea |last10=Paulus |first10=Wilfried |isbn=3527306730 }} and was introduced in 1959. It has a fast knockdown and long residual effect, and is used against turf, forestry, and household pests and fleas. It is also used in pest control for domestic animals, Anopheles mosquitoes, ants, gypsy moths, and other agricultural pests.ACGIH, 1991a{{full|date=April 2010}}Budavari, 1996a{{full|date=April 2010}} It can also be used as a molluscicide.Lewis, 1993a{{full|date=April 2010}}[http://extoxnet.orst.edu/pips/propoxur.htm EXTOXNET Extension Toxicology Network. Pesticide Information Profile. Propoxur.] June 1996.

Several U.S. states have petitioned the Environmental Protection Agency (EPA) to use propoxur against bedbug infestations, but the EPA has been reluctant to approve indoor use because of its potential toxicity to children after chronic exposure.{{cite news |url=https://www.nytimes.com/2010/09/05/opinion/05sun3.html |journal=New York Times |title=In Search of a Bedbug Solution |date=September 4, 2010}}

Action

Carbamate insecticides kill insects by irreversibly inactivating the enzyme acetylcholinesterase, thus it is a Cholinesterase inhibitor.

Environmental effects

Propoxur rapidly breaks down in alkaline solution.[http://www.inchem.org/documents/jmpr/jmpmono/v073pr19.htm Propoxur (WHO Pesticide Residues Series 3):] October 01, 2009. Propoxur is highly toxic to many bird species, although its toxicity varies by the species, and it is highly toxic to honeybees. It is moderately to slightly toxic to fish and other aquatic species.

References