Prostaglandin E synthase

{{Short description|Class of enzymes}}

{{infobox enzyme

| Name = prostaglandin-E synthase

| EC_number = 5.3.99.3

| CAS_number = 52227-79-9

| GO_code = 0050220

| image = 3dww.png

| width =

| caption = human microsomal prostaglandin E synthase 1 with bound glutathione. PDB entry {{PDBe|3DWW}}{{Cite journal

| last1 = Jegerschold | first1 = C.

| last2 = Pawelzik | first2 = S. -C.

| last3 = Purhonen | first3 = P.

| last4 = Bhakat | first4 = P.

| last5 = Gheorghe | first5 = K. R.

| last6 = Gyobu | first6 = N.

| last7 = Mitsuoka | first7 = K.

| last8 = Morgenstern | first8 = R.

| last9 = Jakobsson | first9 = P. -J.

| doi = 10.1073/pnas.0802894105

| last10 = Hebert | first10 = H.

| title = Structural basis for induced formation of the inflammatory mediator prostaglandin E2

| journal = Proceedings of the National Academy of Sciences

| volume = 105

| issue = 32

| pages = 11110–11115

| year = 2008

| pmid = 18682561

| pmc =2516235

| bibcode = 2008PNAS..10511110J

| doi-access = free

}}

}}

Prostaglandin E synthase ({{EnzExplorer|5.3.99.3}}, or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.{{cite journal | vauthors = Murakami M, Nakatani Y, Tanioka T, Kudo I | title = Prostaglandin E synthase | journal = Prostaglandins Other Lipid Mediat. | volume = 68-69 | pages = 383–99 |date=August 2002 | pmid = 12432931 | doi = 10.1016/S0090-6980(02)00043-6| s2cid = 22246484 }}{{cite journal | vauthors = Park JY, Pillinger MH, Abramson SB | title = Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases | journal = Clin. Immunol. | volume = 119 | issue = 3 | pages = 229–40 |date=June 2006 | pmid = 16540375 | doi = 10.1016/j.clim.2006.01.016 }}

The synthase generating PGE2 is a membrane-associated protein.

Image:Eicosanoid_synthesis.svg