Protein Local Optimization Program

{{Infobox software

| name = Protein Local Optimization Program

| logo =

| caption =

| author = Matthew P. Jacobson, Richard A. Friesner

| developer = University of California, San Francisco, Schrödinger

| released = {{Start date and age|2000}}

| latest release version = Schrödinger Release 2016-4{{cite web|title=Prime|url=https://www.schrodinger.com/prime|website=Schrödinger|publisher=Schrödinger, LLC|accessdate=19 January 2017}}

| latest release date = {{Start date and age|2016|04}}

| programming language = Fortran

| operating system = Unix-like

| platform =

| size =

| language = English

| genre = Molecular mechanics

| license = Proprietary commercial, academic freeware{{Cite web|url=http://www.jacobsonlab.org/plop_manual/plop_license.htm|title = PLOP licensing}}

| website = {{URL|wiki.jacobsonlab.org}}

}}

Protein Local Optimization Program (PLOP) is computer software,{{cite web |url=http://wiki.jacobsonlab.org/index.php/Plop |title=Plop – Jacobson Lab Wiki |author= |date= |publisher= |access-date=7 November 2012}} a molecular dynamics simulation package written in the programming language Fortran. It was developed originally by Matthew P. Jacobson and Richard A. Friesner of the Friesner lab at Columbia University, and then moved to the Jacobson lab at University of California, San Francisco (UCSF), and Schrödinger, LLC.