Pyrrolidine alkaloids

Alkaloids with partial pyrrolidine structure are usually sub-categorized based on their occurrence and biogenetic origin. Hygrin and cuscohygrin were isolated from the leaves of the coca shrub, while (-)-codonopsinine was isolated from the woodland vine tiger bell.

Erythroxylum coca.jpg|Coca shrub (Erythroxylum coca) with leaves and fruits.

Codonopsis clematidea Dzwonkowiec powojnikowaty 2015 03.jpg|Wood vine tiger bell (Codonopsis clematidea)

Among the most important representatives of the pyrrolidine alkaloids are hygrin and cuscohygrin.{{citation|author=H. Latscha, U. Kazmaier|date=2016|edition=4|isbn=978-3-662-47783-0|location=Berlin Heidelberg|pages=682|publisher=Springer Spektrum|title=Chemie für Biologen}} Another representative is the (-)-codonopsinine.{{citation|author=J. Reddy, B. Rao|date=2007|doi=10.1021/jo061940q|issue=6|pages=2224–2227|periodical=The Journal of Organic Chemistry|title=A Short, Efficient, and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (−)-Codonopsinine|volume=72|pmid=17316046 }} Furthermore, ruspolinone, norruspolinone and norruspoline also belong to this alkaloid group.{{citation|author=F. Roessler, D. Ganzinger, S. Johne, E.Schöpp, M. Hesse|date=1978|doi=10.1002/hlca.19780610336|issue=3|pages=1200–1206|periodical=Helvetica Chimica Acta|title=Ruspolia hypercrateriformis M.R.:Isolierung und Strukturaufklärung von neuen Pyrrolidin-Alkaloiden. 169. Mitt. über organische Naturstoffe|volume=61}}

(+)-Hygrine Structural Formula V2.svg|(+)-Hygrine

(-)-Codonopsinine Structural Formula V2.svg|(-)-Codonopsinine

(-)-Ruspolinone Structural Formula V1.svg|(-)-Ruspolinone

(R)-Norruspoline Structural Formula V1.svg|(R)-Norruspoline

Many plants containing cuscohygrin are used in the folk medicine of various peoples as sedatives or narcotics.{{RömppOnline|ID=RD-03-02974|Name=Cuscohygrin|Abruf=2020-05-21}}

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Category:Alkaloids

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