QPCT
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Glutaminyl-peptide cyclotransferase is an enzyme that in humans is encoded by the QPCT gene.{{cite journal | vauthors = Song I, Chuang CZ, ((Bateman RC Jr)) | title = Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase | journal = J Mol Endocrinol | volume = 13 | issue = 1 | pages = 77–86 |date=Jan 1995 | pmid = 7999256 | doi =10.1677/jme.0.0130077 }}{{cite web | title = Entrez Gene: QPCT glutaminyl-peptide cyclotransferase (glutaminyl cyclase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25797}}
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
References
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Further reading
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- {{cite journal |vauthors=Busby WH, Quackenbush GE, Humm J, etal |title=An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes |journal=J. Biol. Chem. |volume=262 |issue= 18 |pages= 8532–6 |year= 1987 |doi=10.1016/S0021-9258(18)47446-7 |pmid= 3597387 |doi-access=free |url=https://cdr.lib.unc.edu/downloads/sb397j47f }}
- {{cite journal | vauthors=Bateman RC, Temple JS, Misquitta SA, Booth RE |title=Evidence for essential histidines in human pituitary glutaminyl cyclase |journal=Biochemistry |volume=40 |issue= 37 |pages= 11246–50 |year= 2001 |pmid= 11551224 |doi=10.1021/bi011177o }}
- {{cite journal |vauthors=Schilling S, Hoffmann T, Rosche F, etal |title=Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity |journal=Biochemistry |volume=41 |issue= 35 |pages= 10849–57 |year= 2002 |pmid= 12196024 |doi=10.1021/bi0260381 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Schilling S, Niestroj AJ, Rahfeld JU, etal |title=Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49773–9 |year= 2004 |pmid= 14522962 |doi= 10.1074/jbc.M309077200 |doi-access= free}}
- {{cite journal | vauthors=Booth RE, Misquitta SA, Bateman RC |title=Human pituitary glutaminyl cyclase: expression in insect cells and dye affinity purification |journal=Protein Expr. Purif. |volume=32 |issue= 1 |pages= 141–6 |year= 2004 |pmid= 14680951 |doi= 10.1016/S1046-5928(03)00226-2 }}
- {{cite journal |vauthors=Ezura Y, Kajita M, Ishida R, etal |title=Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women |journal=J. Bone Miner. Res. |volume=19 |issue= 8 |pages= 1296–301 |year= 2005 |pmid= 15231017 |doi= 10.1359/JBMR.040324 |s2cid=8470506 |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Huang KF, Liu YL, Cheng WJ, etal |title=Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 37 |pages= 13117–22 |year= 2005 |pmid= 16135565 |doi= 10.1073/pnas.0504184102 | pmc=1201592 |bibcode=2005PNAS..10213117H |doi-access=free }}
- {{cite journal | vauthors=Huang QY, Kung AW |title=The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population |journal=Journal of Human Genetics |volume=52 |issue= 9 |pages= 757–62 |year= 2007 |pmid= 17687619 |doi= 10.1007/s10038-007-0178-6 |doi-access= free }}
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