QazCovid-in
{{short description|Vaccine candidate against COVID-19}}
{{Update|date=January 2025}}
{{Use dmy dates|date=March 2021}}
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| type = vaccine
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| target = SARS-CoV-2
| vaccine_type = inactivated
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| routes_of_administration = Intramuscular
| CAS_number = 2541708-50-1
| index2_label = QazCoVac-P
| CAS_number2 = 2699021-46-8
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| DrugBank = DB16441
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{{COVID-19 pandemic sidebar}}
QazCovid-in, commercially known as QazVac,{{Cite web | vauthors = Kumenov A | date = 1 April 2021 |title=Kazakhstan: Officials under fire over vaccination failures | work = Eurasianet|url=https://eurasianet.org/kazakhstan-officials-under-fire-over-vaccination-failures|access-date= 11 April 2021 |language=en}}{{Cite web |vauthors=Tatyana K |date=31 March 2021 |title=Vaccination with homegrown QazVac vaccine likely to start in late April |url=https://www.inform.kz/en/article/3770566 |access-date=11 April 2021 |website=www.inform.kz |language=en }}{{Dead link|date=October 2023 |bot=InternetArchiveBot |fix-attempted=yes }} is a COVID-19 vaccine developed by the Research Institute for Biological Safety Problems in Kazakhstan.{{cite web | vauthors = Yergaliyeva A |title=Kazakhstan Begins Vaccinating 3,000 Volunteers With Self-Made QazCovid-in |url=https://astanatimes.com/2020/12/kazakhstan-begins-vaccinating-3000-volunteers-with-self-made-qazcovid-in/ |website=The Astana Times |access-date=2 March 2021 |date=20 December 2020}}{{ClinicalTrialsGov|NCT04691908|Immunogenicity, Efficacy and Safety of QazCovid-in® COVID-19 Vaccine}} QazCoVac-P was the second COVID-19 vaccine developed by the Kazakh Biosafety Research Institute and in clinical trials.{{cite news | vauthors = Arystanbek A |title=Kazakh Biosafety Research Institute Begins Clinical Trials of Another Vaccine Against COVID-19 |url=https://astanatimes.com/2021/06/kazakh-biosafety-research-institute-begins-clinical-trials-of-another-vaccine-against-covid-19/ |publisher=The Astana Times}}
Manufacturing
The vaccine can be stored at standard refrigeration temperatures (2 °C-8 °C) and is a two-dose régime with the doses administered twenty-one days apart.{{Cite web | vauthors = Tatyana K |date=26 April 2021|title=Health Minister Alexei Tsoi to be one of the first to get homegrown QazCovid-in vaccine|url=https://www.inform.kz/en/article/3780770|access-date=26 April 2021|website=www.inform.kz|language=en}} The vaccine was first manufactured by Kazakhstan's Research Institute of Biological Safety Problems. Production capacity has been capped at 50,000 doses per month.{{citation needed|date=January 2023}}
Beginning in June 2021, the vaccine is slatedIt's unclear at which level of preparation the vaccine will be sent to Turkey. to be packaged in large bulk to be bottled in Turkey by a major Turkish company. This will allow for a production capacity of 500,000-600,000 doses per month.{{Cite web | vauthors = Batyrov A | date = 25 April 2021 |title=Kazakhstan Launches Production of First Homegrown Vaccine, 'QazVac'|url=https://caspiannews.com/news-detail/kazakhstan-launches-production-of-first-homegrown-vaccine-qazvac-2021-4-25-0/|access-date=26 April 2021|website=caspiannews.com|language=en}} The contract is still being negotiated,{{Cite web | vauthors = Tatyana K |date= 21 April 2021 |title=Healthcare Ministry comments on production of QazVac vaccine|url=https://www.inform.kz/en/article/3779242|access-date=2021-04-22|website=www.inform.kz|language=en}} despite earlier claims suggesting that the deal had already been finalized.{{Cite web | date = |title=К концу апреля в Казахстане будет выпущено 50000 доз собственной вакцины | trans-title = By the end of April, 50,000 doses of its own vaccine will be released in Kazakhstan | language = ru |url=https://sng.today/astana/16518-k-koncu-aprelja-v-kazahstane-budet-vypuscheno-50000-doz-sobstvennoj-vakciny.html|access-date=2021-04-12|website= SNG.TODAY}}{{Cite web | vauthors = Kussainova M | date = 10 April 2021 |title=Kazakhstan's COVID-19 vaccine to be bottled in Turkey|url=https://www.aa.com.tr/en/asia-pacific/kazakhstans-covid-19-vaccine-to-be-bottled-in-turkey/2204040|access-date=2021-04-12|website=www.aa.com.tr}}
In October 2021, it was announced that the vaccine would be supplied to Afghanistan and other countries in 2022.{{Cite web| vauthors = Satubaldina A |date=October 5, 2021|title=Kazakhstan to Supply Its QazVac COVID-19 Vaccine to Other Countries Next Year |url= https://astanatimes.com/2021/10/kazakhstan-to-supply-its-qazvac-covid-19-vaccine-to-other-countries-next-year/ |website=The Astana Times}}
History
= Clinical trials =
In September 2020, QazVac started in Phase I/II clinical trials.{{ClinicalTrialsGov|NCT04530357|Reactogenicity, Safety and Immunogenicity of QazCovid-in® COVID-19 Vaccine}}
In December 2020, QazVac is currently in Phase III clinical trials, which is expected to be fully completed by 9 July 2021.{{Cite web | vauthors =Akulova O, Gani T | date = 9 April 2021 |title= QazVac готова и уже на подходе | trans-title = QazVac is ready and on the way |url= https://time.kz/articles/zloba/2021/04/09/qazvac-gotova-i-uzhe-na-podhode |access-date=11 April 2021| work = Время | trans-work = Time |language=ru}} It is unclear when the first preliminary results will be published.{{Cite web | vauthors = Tatyana K |date=9 April 2021|title=3rd stage of clinical trials of QazCovid-in vaccine to be 50% complete by Apr 15|url=https://www.inform.kz/en/article/3774242|access-date=11 April 2021|website=www.inform.kz|language=en}}
The administration of the vaccine for the general population began at the end of April 2021.{{Cite web | vauthors = Ondiris A |date=2021-04-09|title=Как правильно применять казахстанскую вакцину QazVac, рассказал ученый | trans-title = How to properly apply the Kazakh vaccine QazVac |url=https://tengrinews.kz/news/pravilno-primenyat-kazahstanskuyu-vaktsinu-qazvac-rasskazal-434119/|access-date=11 April 2021|website=Главные новости Казахстана - Tengrinews.kz|language=ru}} The Research Institute Kunsulu Zakarya's Director General's justification is that the trial is almost 50% completed and "people who have received [the] vaccine feel well; there have been no side-effects and the effectiveness of the vaccine is high".
In September 2021, a study was published to eClinicalMedicine, published by The Lancet. The study’s findings were that the “QazCovid-in® vaccine was safe and well-tolerated and induced predominantly mild adverse events; no serious or severe adverse events were recorded in both trials.” {{cite journal | vauthors = Zakarya K, Kutumbetov L, Orynbayev M, Abduraimov Y, Sultankulova K, Kassenov M, Sarsenbayeva G, Kulmagambetov I, Davlyatshin T, Sergeeva M, Stukova M, Khairullin B | display-authors = 6 | title = Safety and immunogenicity of a QazCovid-in® inactivated whole-virion vaccine against COVID-19 in healthy adults: A single-centre, randomised, single-blind, placebo-controlled phase 1 and an open-label phase 2 clinical trials with a 6 months follow-up in Kazakhstan | journal = eClinicalMedicine | volume = 39 | pages = 101078 | date = September 2021 | pmid = 34414368 | pmc = 8363482 | doi = 10.1016/j.eclinm.2021.101078 }}
= Authorization =
{{See also|List of COVID-19 vaccine authorizations#QazCovid-in}}
Economics
The first batch of 50,000 doses was delivered on 26 April 2021, and vaccination began shortly after.{{citation needed|date=September 2021}} In June 2021, the capacity will increase to 100,000 doses per month, regardless of the contract for bottling in Turkey.{{Cite web | vauthors = Mauletbay S |date= 9 April 2021|title=Казахстанскую вакцину QazVac будут разливать в Турции | trans-title = Kazakhstan vaccine QazVac will be bottled in Turkey |url=https://informburo.kz/novosti/kazahstanskuyu-vakcinu-qaz-vac-budut-razlivat-v-turcii|access-date=2021-04-12|website=informburo.kz|language=ru}}
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References
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External links
{{scholia|Q99518269}}
{{Vaccines}}
{{COVID-19 pandemic}}
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