Quebec Route 281

{{Short description|Highway in Quebec}}

{{Infobox road

| province = QC

| type = QC

| route = 281

| maint =

| map = Route 281-QC.png

| established =

| decommissioned =

| alternate_name =

| length_km = 75

| length_round = 1

| length_ref = Ministère des transports, "Distances routières", page (?), Les Publications du Québec, 2005

| direction_a = North

| direction_b = South

| terminus_a = {{jct|state=QC|QC|132}} near Saint-Michel-de-Bellechasse|

| terminus_b = {{jct|state=QC|QC|204}} in Saint-Camille-de-Lellis|

| previous_type = QC

| previous_route = 279

| next_type = QC

| next_route = 283

| cities = Saint-Michel-de-Bellechasse

Saint-Camille-de-Lellis

Saint-Magloire

Saint-Philémon

Armagh

Saint-Raphaël

La Durantaye

| junction ={{jct|state=QC|TCH|20}} near La Durantaye|

}}

Route 281 is a 75 km two-lane north/south highway in the Chaudière-Appalaches region in the province of Quebec, Canada. Its northern terminus is in St-Michel at the junction of Route 132 and its southern terminus is close to Saint-Camille-de-Lellis at the junction of Route 204.