Quebec Route 381

{{Short description|Highway in Quebec, Canada}}

{{Use Canadian English|date=January 2023}}

{{Infobox road

|province=QC

|type=QC

|route=381

|maint=Transports Québec

|map=Route 381-QC.png

|established=

|decommissioned=

|alternate_name=

|length_km =114

|length_round =1

|length_ref=Ministère des transports, "Distances routières", page (?), Les Publications du Québec, 2005

|direction_a=North

|direction_b=South

|terminus_a={{jct|state=QC|QC|170}} in Saguenay (La Baie)

|terminus_b={{jct|state=QC|QC|138}} in Baie-Saint-Paul

|previous_type=QC

|previous_route=373

|next_type=QC

|next_route=382

|cities=Saguenay, Baie-Saint-Paul

|junction=

}}

Route 381 is a provincial highway located in the Capitale-Nationale and Saguenay–Lac-Saint-Jean regions of Quebec, Canada. It runs from Baie-Saint-Paul (in Charlevoix) at the junction of Route 138 and ends in the La Baie sector of the City of Saguenay at the junction of Route 170.