RAET1G

Retinoic acid early transcript 1G (RAET1G) is a cell surface glycoprotein encoded by RAET1G gene located on chromosome 6.{{Cite journal|title = A Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2–q25.3|journal = Genomics|date = 2002-01-01|pages = 114–123|volume = 79|issue = 1|doi = 10.1006/geno.2001.6673|first = Mirjana|last = Radosavljevic|first2 = Benoı̂t|last2 = Cuillerier|first3 = Michael J.|last3 = Wilson|first4 = Oliver|last4 = Clément|first5 = Sophie|last5 = Wicker|first6 = Susan|last6 = Gilfillan|first7 = Stephan|last7 = Beck|first8 = John|last8 = Trowsdale|first9 = Seiamak|last9 = Bahram|pmid=11827464}} RAET1G is related to MHC class I molecules, but its gene maps outside the MHC locus. RAET1G is composed of an external α1α2 domain, a transmembrane segment, and C-terminal cytoplasmic tail.{{Cite journal|title = Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D|journal = The Journal of Immunology|date = 2004-07-15|issn = 0022-1767|pmid = 15240696|pages = 1078–1084|volume = 173|issue = 2|doi = 10.4049/jimmunol.173.2.1078|first = Louise|last = Bacon|first2 = Robert A.|last2 = Eagle|first3 = Martina|last3 = Meyer|first4 = Nicholas|last4 = Easom|first5 = Neil T.|last5 = Young|first6 = John|last6 = Trowsdale|doi-access = free}} RAET1E functions as a stress-induced ligand for NKG2D receptors.