RAP1B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B gene.{{cite web | title = Entrez Gene: RAP1B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5908}}{{cite journal |vauthors=Pizon V, Lerosey I, Chardin P, Tavitian A | title = Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B) | journal = Nucleic Acids Res. | volume = 16 | issue = 15 | pages = 7719 |date=August 1988 | pmid = 3137530 | pmc = 338441 | doi = 10.1093/nar/16.15.7719}}{{cite journal |vauthors=Matsui Y, Kikuchi A, Kawata M, Kondo J, Teranishi Y, Takai Y | title = Molecular cloning of smg p21B and identification of smg p21 purified from bovine brain and human platelets as smg p21B | journal = Biochem. Biophys. Res. Commun. | volume = 166 | issue = 2 | pages = 1010–6 |date=January 1990 | pmid = 2105724 | doi = 10.1016/0006-291X(90)90911-6}}{{cite journal |vauthors=Rousseau-Merck MF, Pizon V, Tavitian A, Berger R | title = Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively | journal = Cytogenet. Cell Genet. | volume = 53 | issue = 1 | pages = 2–4 | year = 1990 | pmid = 2108841 | doi = 10.1159/000132883}}
References
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Further reading
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- {{cite journal |vauthors=Rehmann H, Arias-Palomo E, Hadders MA, etal |title=Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. |journal=Nature |volume=455 |issue= 7209 |pages= 124–7 |year= 2008 |pmid= 18660803 |doi= 10.1038/nature07187 |bibcode=2008Natur.455..124R |s2cid=4393652 }}
- {{cite journal |vauthors=Gyan E, Frew M, Bowen D, etal |title=Mutation in RAP1 is a rare event in myelodysplastic syndromes. |journal=Leukemia |volume=19 |issue= 9 |pages= 1678–80 |year= 2005 |pmid= 16118622 |doi= 10.1038/sj.leu.2403882 |doi-access= free }}
- {{cite journal |vauthors=Carmona G, Göttig S, Orlandi A, etal |title=Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. |journal=Blood |volume=113 |issue= 2 |pages= 488–97 |year= 2009 |pmid= 18805968 |doi= 10.1182/blood-2008-02-138438 |s2cid=206868671 |doi-access=free }}
- {{cite journal |author=Shattil SJ |title=Integrins and Src: dynamic duo of adhesion signaling. |journal=Trends Cell Biol. |volume=15 |issue= 8 |pages= 399–403 |year= 2005 |pmid= 16005629 |doi= 10.1016/j.tcb.2005.06.005 }}
- {{cite journal |vauthors=Malchinkhuu E, Sato K, Maehama T, etal |title=Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. |journal=Mol. Biol. Cell |volume=20 |issue= 24 |pages= 5156–65 |year= 2009 |pmid= 19864456 |doi= 10.1091/mbc.E09-08-0692 |pmc=2793292}}
- {{cite journal |vauthors=Daumke O, Weyand M, Chakrabarti PP, etal |title=The GTPase-activating protein Rap1GAP uses a catalytic asparagine. |journal=Nature |volume=429 |issue= 6988 |pages= 197–201 |year= 2004 |pmid= 15141215 |doi= 10.1038/nature02505 |bibcode=2004Natur.429..197D |s2cid=4426744 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
- {{cite journal |vauthors=Edreira MM, Li S, Hochbaum D, etal |title=Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop. |journal=J. Biol. Chem. |volume=284 |issue= 40 |pages= 27480–6 |year= 2009 |pmid= 19651783 |doi= 10.1074/jbc.M109.011312 |pmc=2785677|doi-access=free }}
- {{cite journal |vauthors=Scrima A, Thomas C, Deaconescu D, Wittinghofer A |title=The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. |journal=EMBO J. |volume=27 |issue= 7 |pages= 1145–53 |year= 2008 |pmid= 18309292 |doi= 10.1038/emboj.2008.30 |pmc=2265111}}
- {{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 |pmc=1347501}}
- {{cite journal |vauthors=Canobbio I, Trionfini P, Guidetti GF, etal |title=Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets. |journal=Cell. Signal. |volume=20 |issue= 9 |pages= 1662–70 |year= 2008 |pmid= 18582561 |doi= 10.1016/j.cellsig.2008.05.016 }}
- {{cite journal |vauthors=Bernardi B, Guidetti GF, Campus F, etal |title=The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3. |journal=Blood |volume=107 |issue= 7 |pages= 2728–35 |year= 2006 |pmid= 16357324 |doi= 10.1182/blood-2005-07-3023 |pmc=1895386}}
- {{cite journal |vauthors=Matsuse M, Mitsutake N, Rogounovitch T, etal |title=Mutation analysis of RAP1 gene in papillary thyroid carcinomas. |journal=Endocr. J. |volume=56 |issue= 1 |pages= 161–4 |year= 2009 |pmid= 18948674 |doi= 10.1507/endocrj.k08e-244|doi-access=free }}
- {{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 |pmc=528930}}
- {{cite journal |vauthors=Li YH, Werner H, Püschel AW |title=Rheb and mTOR regulate neuronal polarity through Rap1B. |journal=J. Biol. Chem. |volume=283 |issue= 48 |pages= 33784–92 |year= 2008 |pmid= 18842593 |doi= 10.1074/jbc.M802431200 |pmc=2662285|doi-access=free }}
- {{cite journal |vauthors=Lova P, Campus F, Lombardi R, etal |title=Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin. |journal=J. Biol. Chem. |volume=279 |issue= 24 |pages= 25299–306 |year= 2004 |pmid= 15078882 |doi= 10.1074/jbc.M313199200 |doi-access= free }}
- {{cite journal |vauthors=Yan J, Li F, Ingram DA, Quilliam LA |title=Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions. |journal=Mol. Cell. Biol. |volume=28 |issue= 18 |pages= 5803–10 |year= 2008 |pmid= 18625726 |doi= 10.1128/MCB.00393-08 |pmc=2546931}}
- {{cite journal |vauthors=Campus F, Lova P, Bertoni A, etal |title=Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24386–95 |year= 2005 |pmid= 15863506 |doi= 10.1074/jbc.M501174200 |doi-access= free }}
- {{cite journal |vauthors=Defilippi P, Di Stefano P, Cabodi S |title=p130Cas: a versatile scaffold in signaling networks. |journal=Trends Cell Biol. |volume=16 |issue= 5 |pages= 257–63 |year= 2006 |pmid= 16581250 |doi= 10.1016/j.tcb.2006.03.003 }}
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